The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss
Objective To ascertain the relationship among vestibular schwannoma (VS) tumor volume, growth, and hearing loss. Study Design Retrospective cohort study. Setting Single tertiary center. Subjects and Methods Adults with observed VS and serviceable hearing at diagnosis were included. The primary outco...
Gespeichert in:
| Veröffentlicht in: | Otolaryngology-head and neck surgery 2020-04, Vol.162 (4), p.530-537 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 537 |
|---|---|
| container_issue | 4 |
| container_start_page | 530 |
| container_title | Otolaryngology-head and neck surgery |
| container_volume | 162 |
| creator | Patel, Neil S. Huang, Alice E. Dowling, Eric M. Lees, Katherine A. Tombers, Nicole M. Lohse, Christine M. Marinelli, John P. Van Gompel, Jamie J. Neff, Brian A. Driscoll, Colin L. W. Link, Michael J. Carlson, Matthew L. |
| description | Objective
To ascertain the relationship among vestibular schwannoma (VS) tumor volume, growth, and hearing loss.
Study Design
Retrospective cohort study.
Setting
Single tertiary center.
Subjects and Methods
Adults with observed VS and serviceable hearing at diagnosis were included. The primary outcome was the development of nonserviceable hearing as estimated using the Kaplan-Meier method. Associations of tumor volume with baseline hearing were assessed using Spearman rank correlation coefficients. Associations of volume and growth with the development of nonserviceable hearing over time were assessed using Cox proportional hazards models and summarized with hazard ratios (HRs).
Results
Of 230 patients with VS and serviceable hearing at diagnosis, 213 had serial volumetric tumor data for analysis. Larger tumor volume at diagnosis was associated with increased pure-tone average (PTA) (P < .001) and decreased word recognition score (WRS) (P = .014). Estimated rates of maintaining serviceable hearing at 6 and 10 years following diagnosis were 67% and 49%, respectively. Larger initial tumor volume was associated with development of nonserviceable hearing in a univariable setting (HR for 1-cm3 increase: 1.36, P = .040) but not after adjusting for PTA and WRS. Tumor growth was not significantly associated with time to nonserviceable hearing (HR, 1.57; P = .14), although estimated rates of maintaining serviceable hearing during observation were poorer in the group that experienced growth.
Conclusion
Larger initial VS tumor volume was associated with poorer hearing at baseline. Larger initial tumor volume was also associated with the development of nonserviceable hearing during observation in a univariable setting; however, this association was not statistically significant after adjusting for baseline hearing status. |
| doi_str_mv | 10.1177/0194599819900396 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2347515346</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_0194599819900396</sage_id><sourcerecordid>2347515346</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4520-65d4dedbf095579a05271d6606e438944b270e430fcc7e8660535bac7a7acc803</originalsourceid><addsrcrecordid>eNqFkL1PwzAUxC0EoqWwMyGPLIHnxh_xCBX9kKp2oHSNHMdpUyV2sRtV_e9J1cKAhJjek-53p9MhdE_giRAhnoFIyqRMiJQAseQXqEtAiognRFyi7lGOjnoH3YSwAQDOhbhGnZjIhEtBumi2WBs8sUXVGKsNdgVemrArs6ZSHr_r9V5Z62qFF03tPF66qqkNVjbHI-_2uzV2Fo-N8qVd4akL4RZdFaoK5u58e-hj-LYYjKPpfDQZvEwjTVkfIs5ymps8K0AyJqQC1hck5xy4oXEiKc36AtoXCq2FSVqBxSxTWiihtE4g7qHHU-7Wu8-mbZzWZdCmqpQ1rglpP6aCERZT3qJwQrVvC3pTpFtf1sofUgLpccX094qt5eGc3mS1yX8M37O1QHIC9mVlDv8GpvPx7HUIiaDH5tHJGtTKpBvXeNsO9XeXL4wKiGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2347515346</pqid></control><display><type>article</type><title>The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss</title><source>Access via SAGE</source><source>Access via Wiley Online Library</source><creator>Patel, Neil S. ; Huang, Alice E. ; Dowling, Eric M. ; Lees, Katherine A. ; Tombers, Nicole M. ; Lohse, Christine M. ; Marinelli, John P. ; Van Gompel, Jamie J. ; Neff, Brian A. ; Driscoll, Colin L. W. ; Link, Michael J. ; Carlson, Matthew L.</creator><creatorcontrib>Patel, Neil S. ; Huang, Alice E. ; Dowling, Eric M. ; Lees, Katherine A. ; Tombers, Nicole M. ; Lohse, Christine M. ; Marinelli, John P. ; Van Gompel, Jamie J. ; Neff, Brian A. ; Driscoll, Colin L. W. ; Link, Michael J. ; Carlson, Matthew L.</creatorcontrib><description>Objective
To ascertain the relationship among vestibular schwannoma (VS) tumor volume, growth, and hearing loss.
Study Design
Retrospective cohort study.
Setting
Single tertiary center.
Subjects and Methods
Adults with observed VS and serviceable hearing at diagnosis were included. The primary outcome was the development of nonserviceable hearing as estimated using the Kaplan-Meier method. Associations of tumor volume with baseline hearing were assessed using Spearman rank correlation coefficients. Associations of volume and growth with the development of nonserviceable hearing over time were assessed using Cox proportional hazards models and summarized with hazard ratios (HRs).
Results
Of 230 patients with VS and serviceable hearing at diagnosis, 213 had serial volumetric tumor data for analysis. Larger tumor volume at diagnosis was associated with increased pure-tone average (PTA) (P < .001) and decreased word recognition score (WRS) (P = .014). Estimated rates of maintaining serviceable hearing at 6 and 10 years following diagnosis were 67% and 49%, respectively. Larger initial tumor volume was associated with development of nonserviceable hearing in a univariable setting (HR for 1-cm3 increase: 1.36, P = .040) but not after adjusting for PTA and WRS. Tumor growth was not significantly associated with time to nonserviceable hearing (HR, 1.57; P = .14), although estimated rates of maintaining serviceable hearing during observation were poorer in the group that experienced growth.
Conclusion
Larger initial VS tumor volume was associated with poorer hearing at baseline. Larger initial tumor volume was also associated with the development of nonserviceable hearing during observation in a univariable setting; however, this association was not statistically significant after adjusting for baseline hearing status.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1177/0194599819900396</identifier><identifier>PMID: 31986971</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>acoustic neuroma ; cranial base ; hearing loss ; neurotology ; skull base ; vestibular schwannoma</subject><ispartof>Otolaryngology-head and neck surgery, 2020-04, Vol.162 (4), p.530-537</ispartof><rights>American Academy of Otolaryngology–Head and Neck Surgery Foundation 2020</rights><rights>2020 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4520-65d4dedbf095579a05271d6606e438944b270e430fcc7e8660535bac7a7acc803</citedby><cites>FETCH-LOGICAL-c4520-65d4dedbf095579a05271d6606e438944b270e430fcc7e8660535bac7a7acc803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0194599819900396$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0194599819900396$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1417,21819,27924,27925,43621,43622,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31986971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Neil S.</creatorcontrib><creatorcontrib>Huang, Alice E.</creatorcontrib><creatorcontrib>Dowling, Eric M.</creatorcontrib><creatorcontrib>Lees, Katherine A.</creatorcontrib><creatorcontrib>Tombers, Nicole M.</creatorcontrib><creatorcontrib>Lohse, Christine M.</creatorcontrib><creatorcontrib>Marinelli, John P.</creatorcontrib><creatorcontrib>Van Gompel, Jamie J.</creatorcontrib><creatorcontrib>Neff, Brian A.</creatorcontrib><creatorcontrib>Driscoll, Colin L. W.</creatorcontrib><creatorcontrib>Link, Michael J.</creatorcontrib><creatorcontrib>Carlson, Matthew L.</creatorcontrib><title>The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objective
To ascertain the relationship among vestibular schwannoma (VS) tumor volume, growth, and hearing loss.
Study Design
Retrospective cohort study.
Setting
Single tertiary center.
Subjects and Methods
Adults with observed VS and serviceable hearing at diagnosis were included. The primary outcome was the development of nonserviceable hearing as estimated using the Kaplan-Meier method. Associations of tumor volume with baseline hearing were assessed using Spearman rank correlation coefficients. Associations of volume and growth with the development of nonserviceable hearing over time were assessed using Cox proportional hazards models and summarized with hazard ratios (HRs).
Results
Of 230 patients with VS and serviceable hearing at diagnosis, 213 had serial volumetric tumor data for analysis. Larger tumor volume at diagnosis was associated with increased pure-tone average (PTA) (P < .001) and decreased word recognition score (WRS) (P = .014). Estimated rates of maintaining serviceable hearing at 6 and 10 years following diagnosis were 67% and 49%, respectively. Larger initial tumor volume was associated with development of nonserviceable hearing in a univariable setting (HR for 1-cm3 increase: 1.36, P = .040) but not after adjusting for PTA and WRS. Tumor growth was not significantly associated with time to nonserviceable hearing (HR, 1.57; P = .14), although estimated rates of maintaining serviceable hearing during observation were poorer in the group that experienced growth.
Conclusion
Larger initial VS tumor volume was associated with poorer hearing at baseline. Larger initial tumor volume was also associated with the development of nonserviceable hearing during observation in a univariable setting; however, this association was not statistically significant after adjusting for baseline hearing status.</description><subject>acoustic neuroma</subject><subject>cranial base</subject><subject>hearing loss</subject><subject>neurotology</subject><subject>skull base</subject><subject>vestibular schwannoma</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkL1PwzAUxC0EoqWwMyGPLIHnxh_xCBX9kKp2oHSNHMdpUyV2sRtV_e9J1cKAhJjek-53p9MhdE_giRAhnoFIyqRMiJQAseQXqEtAiognRFyi7lGOjnoH3YSwAQDOhbhGnZjIhEtBumi2WBs8sUXVGKsNdgVemrArs6ZSHr_r9V5Z62qFF03tPF66qqkNVjbHI-_2uzV2Fo-N8qVd4akL4RZdFaoK5u58e-hj-LYYjKPpfDQZvEwjTVkfIs5ymps8K0AyJqQC1hck5xy4oXEiKc36AtoXCq2FSVqBxSxTWiihtE4g7qHHU-7Wu8-mbZzWZdCmqpQ1rglpP6aCERZT3qJwQrVvC3pTpFtf1sofUgLpccX094qt5eGc3mS1yX8M37O1QHIC9mVlDv8GpvPx7HUIiaDH5tHJGtTKpBvXeNsO9XeXL4wKiGQ</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Patel, Neil S.</creator><creator>Huang, Alice E.</creator><creator>Dowling, Eric M.</creator><creator>Lees, Katherine A.</creator><creator>Tombers, Nicole M.</creator><creator>Lohse, Christine M.</creator><creator>Marinelli, John P.</creator><creator>Van Gompel, Jamie J.</creator><creator>Neff, Brian A.</creator><creator>Driscoll, Colin L. W.</creator><creator>Link, Michael J.</creator><creator>Carlson, Matthew L.</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss</title><author>Patel, Neil S. ; Huang, Alice E. ; Dowling, Eric M. ; Lees, Katherine A. ; Tombers, Nicole M. ; Lohse, Christine M. ; Marinelli, John P. ; Van Gompel, Jamie J. ; Neff, Brian A. ; Driscoll, Colin L. W. ; Link, Michael J. ; Carlson, Matthew L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4520-65d4dedbf095579a05271d6606e438944b270e430fcc7e8660535bac7a7acc803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>acoustic neuroma</topic><topic>cranial base</topic><topic>hearing loss</topic><topic>neurotology</topic><topic>skull base</topic><topic>vestibular schwannoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Neil S.</creatorcontrib><creatorcontrib>Huang, Alice E.</creatorcontrib><creatorcontrib>Dowling, Eric M.</creatorcontrib><creatorcontrib>Lees, Katherine A.</creatorcontrib><creatorcontrib>Tombers, Nicole M.</creatorcontrib><creatorcontrib>Lohse, Christine M.</creatorcontrib><creatorcontrib>Marinelli, John P.</creatorcontrib><creatorcontrib>Van Gompel, Jamie J.</creatorcontrib><creatorcontrib>Neff, Brian A.</creatorcontrib><creatorcontrib>Driscoll, Colin L. W.</creatorcontrib><creatorcontrib>Link, Michael J.</creatorcontrib><creatorcontrib>Carlson, Matthew L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Neil S.</au><au>Huang, Alice E.</au><au>Dowling, Eric M.</au><au>Lees, Katherine A.</au><au>Tombers, Nicole M.</au><au>Lohse, Christine M.</au><au>Marinelli, John P.</au><au>Van Gompel, Jamie J.</au><au>Neff, Brian A.</au><au>Driscoll, Colin L. W.</au><au>Link, Michael J.</au><au>Carlson, Matthew L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2020-04</date><risdate>2020</risdate><volume>162</volume><issue>4</issue><spage>530</spage><epage>537</epage><pages>530-537</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objective
To ascertain the relationship among vestibular schwannoma (VS) tumor volume, growth, and hearing loss.
Study Design
Retrospective cohort study.
Setting
Single tertiary center.
Subjects and Methods
Adults with observed VS and serviceable hearing at diagnosis were included. The primary outcome was the development of nonserviceable hearing as estimated using the Kaplan-Meier method. Associations of tumor volume with baseline hearing were assessed using Spearman rank correlation coefficients. Associations of volume and growth with the development of nonserviceable hearing over time were assessed using Cox proportional hazards models and summarized with hazard ratios (HRs).
Results
Of 230 patients with VS and serviceable hearing at diagnosis, 213 had serial volumetric tumor data for analysis. Larger tumor volume at diagnosis was associated with increased pure-tone average (PTA) (P < .001) and decreased word recognition score (WRS) (P = .014). Estimated rates of maintaining serviceable hearing at 6 and 10 years following diagnosis were 67% and 49%, respectively. Larger initial tumor volume was associated with development of nonserviceable hearing in a univariable setting (HR for 1-cm3 increase: 1.36, P = .040) but not after adjusting for PTA and WRS. Tumor growth was not significantly associated with time to nonserviceable hearing (HR, 1.57; P = .14), although estimated rates of maintaining serviceable hearing during observation were poorer in the group that experienced growth.
Conclusion
Larger initial VS tumor volume was associated with poorer hearing at baseline. Larger initial tumor volume was also associated with the development of nonserviceable hearing during observation in a univariable setting; however, this association was not statistically significant after adjusting for baseline hearing status.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>31986971</pmid><doi>10.1177/0194599819900396</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2020-04, Vol.162 (4), p.530-537 |
| issn | 0194-5998 1097-6817 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2347515346 |
| source | Access via SAGE; Access via Wiley Online Library |
| subjects | acoustic neuroma cranial base hearing loss neurotology skull base vestibular schwannoma |
| title | The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A20%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Influence%20of%20Vestibular%20Schwannoma%20Tumor%20Volume%20and%20Growth%20on%20Hearing%20Loss&rft.jtitle=Otolaryngology-head%20and%20neck%20surgery&rft.au=Patel,%20Neil%20S.&rft.date=2020-04&rft.volume=162&rft.issue=4&rft.spage=530&rft.epage=537&rft.pages=530-537&rft.issn=0194-5998&rft.eissn=1097-6817&rft_id=info:doi/10.1177/0194599819900396&rft_dat=%3Cproquest_cross%3E2347515346%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2347515346&rft_id=info:pmid/31986971&rft_sage_id=10.1177_0194599819900396&rfr_iscdi=true |