Analytical Similarity of a Proposed Biosimilar BVZ-BC to Bevacizumab

BVZ-BC (bevacizumab-biosimilar candidate) is a proposed biosimilar to bevacizumab. Bevacizumab binds to vascular endothelial growth factor (VEGF) type A and prevents the interaction of VEGF with its receptors on the surface of endothelial cells, neutralizing angiogenesis required for the growth, per...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-02, Vol.92 (4), p.3161-3170
Hauptverfasser:	Yu, Chuanfei, Zhang, Feng, Xu, Gangling, Wu, Gang, Wang, Wenbo, Liu, Chunyu, Fu, Zhihao, Li, Meng, Guo, Sha, Yu, Xiaojuan, Wang, Lan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Analytical chemistry Angiogenesis Bevacizumab Bioaccumulation Bioassays Biological activity Biological Assay Biological properties Biosimilar Pharmaceuticals - chemistry Biosimilar Pharmaceuticals - metabolism Biosimilar Pharmaceuticals - pharmacology Calorimetry Chemistry Circular dichroism Dichroism Differential scanning calorimetry Endothelial cells Enzyme-linked immunosorbent assay Glycan Growth factors Immunology Immunotherapy Impurities Mathematical analysis Metastases Monoclonal antibodies Polysaccharides - chemistry Quality management Receptors Similarity Solid tumors Targeted cancer therapy Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
Online-Zugang:	Volltext
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