Bioactive Pore‐Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing
The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore‐forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive gl...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2020-03, Vol.32 (10), p.e1907491-n/a |
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| creator | Xu, Liju Gao, Shan Zhou, Rubing Zhou, Fang Qiao, Yan Qiu, Dong |
| description | The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore‐forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass‐involved macropore‐embedded bone adhesives is developed, which is capable of facilitating the migration of bone‐derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass‐particle‐encapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cell‐ingrowth efficacy.
A bioactive macropore‐forming strategy is developed for bone adhesives to improve cell‐ingrowth efficacy. By integrating porogens with pre‐encapsulated bioactive glass particles, bone adhesives can facilitate cell migration and differentiation. A robust instant bonding to fix bone fracture and a high efficiency of bone regeneration on a mouse skull are observed. |
| doi_str_mv | 10.1002/adma.201907491 |
| format | Article |
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A bioactive macropore‐forming strategy is developed for bone adhesives to improve cell‐ingrowth efficacy. By integrating porogens with pre‐encapsulated bioactive glass particles, bone adhesives can facilitate cell migration and differentiation. A robust instant bonding to fix bone fracture and a high efficiency of bone regeneration on a mouse skull are observed.</description><identifier>ISSN: 0935-9648</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.201907491</identifier><identifier>PMID: 31984560</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adhesives ; Adhesives - therapeutic use ; Animals ; bioactive glass ; Biocompatible Materials - therapeutic use ; Bioglass ; Biological activity ; biomaterials ; Biomedical materials ; bone adhesives ; bone healing ; Bone Regeneration ; Cell Proliferation ; Cells, Cultured ; Ceramics - therapeutic use ; Fracture Healing ; Fractures ; Healing ; macropores ; Materials science ; Mesenchymal Stem Cells - cytology ; Mice ; Osteogenesis ; Porosity ; Regeneration (physiology) ; Skull - injuries ; Skull - pathology ; Skull - physiopathology</subject><ispartof>Advanced materials (Weinheim), 2020-03, Vol.32 (10), p.e1907491-n/a</ispartof><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4101-f6ef5063a12814427b414d43924158e18a3fca7088cd7fd6f50c32e704f8d7123</citedby><cites>FETCH-LOGICAL-c4101-f6ef5063a12814427b414d43924158e18a3fca7088cd7fd6f50c32e704f8d7123</cites><orcidid>0000-0003-1069-7756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fadma.201907491$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fadma.201907491$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31984560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Liju</creatorcontrib><creatorcontrib>Gao, Shan</creatorcontrib><creatorcontrib>Zhou, Rubing</creatorcontrib><creatorcontrib>Zhou, Fang</creatorcontrib><creatorcontrib>Qiao, Yan</creatorcontrib><creatorcontrib>Qiu, Dong</creatorcontrib><title>Bioactive Pore‐Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing</title><title>Advanced materials (Weinheim)</title><addtitle>Adv Mater</addtitle><description>The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore‐forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass‐involved macropore‐embedded bone adhesives is developed, which is capable of facilitating the migration of bone‐derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass‐particle‐encapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cell‐ingrowth efficacy.
A bioactive macropore‐forming strategy is developed for bone adhesives to improve cell‐ingrowth efficacy. By integrating porogens with pre‐encapsulated bioactive glass particles, bone adhesives can facilitate cell migration and differentiation. A robust instant bonding to fix bone fracture and a high efficiency of bone regeneration on a mouse skull are observed.</description><subject>Adhesives</subject><subject>Adhesives - therapeutic use</subject><subject>Animals</subject><subject>bioactive glass</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Bioglass</subject><subject>Biological activity</subject><subject>biomaterials</subject><subject>Biomedical materials</subject><subject>bone adhesives</subject><subject>bone healing</subject><subject>Bone Regeneration</subject><subject>Cell Proliferation</subject><subject>Cells, Cultured</subject><subject>Ceramics - therapeutic use</subject><subject>Fracture Healing</subject><subject>Fractures</subject><subject>Healing</subject><subject>macropores</subject><subject>Materials science</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mice</subject><subject>Osteogenesis</subject><subject>Porosity</subject><subject>Regeneration (physiology)</subject><subject>Skull - injuries</subject><subject>Skull - pathology</subject><subject>Skull - physiopathology</subject><issn>0935-9648</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0LFOwzAQBmALgaAUVkYUiYUl5c52YnsshQISCAYQY2QSB4KSGOwExMYj8Iw8CY5aQGJhuuG--3X6CdlBmCAAPdBFoycUUIHgClfICBOKMQeVrJIRKJbEKuVyg2x6_wgAKoV0nWwwVJInKYzI7WFldd5VLya6ss58vn_MrWuq9j46tK2JpsWD8WHpo7nOq7rqdDfsZqauo7P23tnX7iEqrYvmLqT0zkSnRteBbJG1UtfebC_nmNzMj69np_H55cnZbHoe5xwB4zI1ZQIp00glck7FHUdecKYox0QalJqVuRYgZV6IskgDzhk1AngpC4GUjcn-IvfJ2efe-C5rKp-H93RrbO8zynhKlUI50L0_9NH2rg3fBSU441yIQU0WKnfWe2fK7MlVjXZvGUI2VJ4NlWc_lYeD3WVsf9eY4od_dxyAWoDXqjZv_8Rl06OL6W_4Fx-zjGs</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Xu, Liju</creator><creator>Gao, Shan</creator><creator>Zhou, Rubing</creator><creator>Zhou, Fang</creator><creator>Qiao, Yan</creator><creator>Qiu, Dong</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1069-7756</orcidid></search><sort><creationdate>20200301</creationdate><title>Bioactive Pore‐Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing</title><author>Xu, Liju ; Gao, Shan ; Zhou, Rubing ; Zhou, Fang ; Qiao, Yan ; Qiu, Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4101-f6ef5063a12814427b414d43924158e18a3fca7088cd7fd6f50c32e704f8d7123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adhesives</topic><topic>Adhesives - therapeutic use</topic><topic>Animals</topic><topic>bioactive glass</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Bioglass</topic><topic>Biological activity</topic><topic>biomaterials</topic><topic>Biomedical materials</topic><topic>bone adhesives</topic><topic>bone healing</topic><topic>Bone Regeneration</topic><topic>Cell Proliferation</topic><topic>Cells, Cultured</topic><topic>Ceramics - therapeutic use</topic><topic>Fracture Healing</topic><topic>Fractures</topic><topic>Healing</topic><topic>macropores</topic><topic>Materials science</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mice</topic><topic>Osteogenesis</topic><topic>Porosity</topic><topic>Regeneration (physiology)</topic><topic>Skull - injuries</topic><topic>Skull - pathology</topic><topic>Skull - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Liju</creatorcontrib><creatorcontrib>Gao, Shan</creatorcontrib><creatorcontrib>Zhou, Rubing</creatorcontrib><creatorcontrib>Zhou, Fang</creatorcontrib><creatorcontrib>Qiao, Yan</creatorcontrib><creatorcontrib>Qiu, Dong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Liju</au><au>Gao, Shan</au><au>Zhou, Rubing</au><au>Zhou, Fang</au><au>Qiao, Yan</au><au>Qiu, Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive Pore‐Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv Mater</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>32</volume><issue>10</issue><spage>e1907491</spage><epage>n/a</epage><pages>e1907491-n/a</pages><issn>0935-9648</issn><eissn>1521-4095</eissn><abstract>The effectiveness of commercial bone adhesives is known to be hampered by the weak efficacy of cell ingrowth. The strategy of macropore‐forming, especially bioactive macropores, holds considerable promise to circumvent this problem, thereby promoting fracture healing. Herein, a class of bioactive glass‐involved macropore‐embedded bone adhesives is developed, which is capable of facilitating the migration of bone‐derived mesenchymal stromal cells into the adhesive layer and differentiation into osteocytes. The integration of bioactive glass‐particle‐encapsulated porogens in the bone adhesives is key to this approach. A robust instant bonding on the bone adhesive and a high efficiency of bone regeneration on a mouse skull are observed, both of which are vital for clinical applications and personalized surgical procedures. This work represents a general strategy to design biomaterials with high cell‐ingrowth efficacy.
A bioactive macropore‐forming strategy is developed for bone adhesives to improve cell‐ingrowth efficacy. By integrating porogens with pre‐encapsulated bioactive glass particles, bone adhesives can facilitate cell migration and differentiation. A robust instant bonding to fix bone fracture and a high efficiency of bone regeneration on a mouse skull are observed.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31984560</pmid><doi>10.1002/adma.201907491</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1069-7756</orcidid></addata></record> |
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| subjects | Adhesives Adhesives - therapeutic use Animals bioactive glass Biocompatible Materials - therapeutic use Bioglass Biological activity biomaterials Biomedical materials bone adhesives bone healing Bone Regeneration Cell Proliferation Cells, Cultured Ceramics - therapeutic use Fracture Healing Fractures Healing macropores Materials science Mesenchymal Stem Cells - cytology Mice Osteogenesis Porosity Regeneration (physiology) Skull - injuries Skull - pathology Skull - physiopathology |
| title | Bioactive Pore‐Forming Bone Adhesives Facilitating Cell Ingrowth for Fracture Healing |
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