The benefits and mechanisms of exercise training for Parkinson's disease
Parkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substa...
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| Veröffentlicht in: | Life sciences (1973) 2020-03, Vol.245, p.117345-10, Article 117345 |
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| creator | Feng, Ya-Shuo Yang, Si-Dong Tan, Zi-Xuan Wang, Man-Man Xing, Ying Dong, Fang Zhang, Feng |
| description | Parkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substantia nigra. Currently, the main therapeutic method for PD is anti-Parkinson medications, including levodopa, madopar, sirelin, and so on. However, the effect of pharmacological treatment has its own limitations, the most significant of which is that the therapeutic effect of dopaminergic treatments gradually diminishes with time. Exercise training, as an adjunctive treatment and complementary therapy, can improve the plasticity of cortical striatum and increase the release of dopamine. Exercise training has been proven to effectively improve motor disorders (including balance, gait, risk of falls and physical function) and nonmotor disorders (such as sleep impairments, cognitive function and quality of life) in PD patients. In recent years, various types of exercise training have been used to treat PD. In this review, we summarise the exercise therapy mechanisms and the protective effects of different types of exercise training on PD patients.
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| doi_str_mv | 10.1016/j.lfs.2020.117345 |
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[Display omitted]</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2020.117345</identifier><identifier>PMID: 31981631</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Balance ; Cognitive ability ; Disorders ; Dopamine ; Dopamine receptors ; Drug therapy ; Exercise ; Exercise Therapy ; Fitness training programs ; Gait ; Humans ; Levodopa ; Lewy bodies ; Motor dysfunction ; Movement disorders ; Neostriatum ; Neurodegenerative diseases ; Neuroplasticity ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Parkinson's disease ; Physical training ; Quality of life ; Sleep ; Substantia nigra ; Synuclein ; Treatment Outcome</subject><ispartof>Life sciences (1973), 2020-03, Vol.245, p.117345-10, Article 117345</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier BV Mar 15, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-a57e85c4672be445e32d1083cc1eecd110fcc62faac227e1f04167e0b5c4f1d13</citedby><cites>FETCH-LOGICAL-c381t-a57e85c4672be445e32d1083cc1eecd110fcc62faac227e1f04167e0b5c4f1d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320520300928$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31981631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Ya-Shuo</creatorcontrib><creatorcontrib>Yang, Si-Dong</creatorcontrib><creatorcontrib>Tan, Zi-Xuan</creatorcontrib><creatorcontrib>Wang, Man-Man</creatorcontrib><creatorcontrib>Xing, Ying</creatorcontrib><creatorcontrib>Dong, Fang</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><title>The benefits and mechanisms of exercise training for Parkinson's disease</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Parkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substantia nigra. Currently, the main therapeutic method for PD is anti-Parkinson medications, including levodopa, madopar, sirelin, and so on. However, the effect of pharmacological treatment has its own limitations, the most significant of which is that the therapeutic effect of dopaminergic treatments gradually diminishes with time. Exercise training, as an adjunctive treatment and complementary therapy, can improve the plasticity of cortical striatum and increase the release of dopamine. Exercise training has been proven to effectively improve motor disorders (including balance, gait, risk of falls and physical function) and nonmotor disorders (such as sleep impairments, cognitive function and quality of life) in PD patients. In recent years, various types of exercise training have been used to treat PD. In this review, we summarise the exercise therapy mechanisms and the protective effects of different types of exercise training on PD patients.
[Display omitted]</description><subject>Balance</subject><subject>Cognitive ability</subject><subject>Disorders</subject><subject>Dopamine</subject><subject>Dopamine receptors</subject><subject>Drug therapy</subject><subject>Exercise</subject><subject>Exercise Therapy</subject><subject>Fitness training programs</subject><subject>Gait</subject><subject>Humans</subject><subject>Levodopa</subject><subject>Lewy bodies</subject><subject>Motor dysfunction</subject><subject>Movement disorders</subject><subject>Neostriatum</subject><subject>Neurodegenerative diseases</subject><subject>Neuroplasticity</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - therapy</subject><subject>Parkinson's disease</subject><subject>Physical training</subject><subject>Quality of life</subject><subject>Sleep</subject><subject>Substantia nigra</subject><subject>Synuclein</subject><subject>Treatment Outcome</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFOGzEQhi1URELgAXpBlnoolw0ee727ESeEoCBFgkM4W4533DhkveDZVOXtcRTaAwd8GVnz_b_sj7HvIKYgoLpYTzeeplLIfIdalfqAjaGpZ4WoFHxjYyFkWSgp9IgdE62FEFrX6oiNFMwayMyY3S1WyJcY0YeBuI0t79CtbAzUEe89x7-YXCDkQ7Ihhvib-z7xR5ueQ6Q-_iTe5q0lPGGH3m4ITz_mhD3d3iyu74r5w6_766t54VQDQ2F1jY12ZVXLJZalRiVbEI1yDhBdCyC8c5X01jopawQvSqhqFMuc8dCCmrDzfe9L6l-3SIPpAjncbGzEfktGZg1azGT-3oT9-ISu-22K-XVGlkrL3VGZgj3lUk-U0JuXFDqb3gwIs9Ns1iZrNjvNZq85Z84-mrfLDtv_iX9eM3C5BzCr-BMwGXIBo8M2JHSDafvwRf079QSMFA</recordid><startdate>20200315</startdate><enddate>20200315</enddate><creator>Feng, Ya-Shuo</creator><creator>Yang, Si-Dong</creator><creator>Tan, Zi-Xuan</creator><creator>Wang, Man-Man</creator><creator>Xing, Ying</creator><creator>Dong, Fang</creator><creator>Zhang, Feng</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20200315</creationdate><title>The benefits and mechanisms of exercise training for Parkinson's disease</title><author>Feng, Ya-Shuo ; Yang, Si-Dong ; Tan, Zi-Xuan ; Wang, Man-Man ; Xing, Ying ; Dong, Fang ; Zhang, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-a57e85c4672be445e32d1083cc1eecd110fcc62faac227e1f04167e0b5c4f1d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Balance</topic><topic>Cognitive ability</topic><topic>Disorders</topic><topic>Dopamine</topic><topic>Dopamine receptors</topic><topic>Drug therapy</topic><topic>Exercise</topic><topic>Exercise Therapy</topic><topic>Fitness training programs</topic><topic>Gait</topic><topic>Humans</topic><topic>Levodopa</topic><topic>Lewy bodies</topic><topic>Motor dysfunction</topic><topic>Movement disorders</topic><topic>Neostriatum</topic><topic>Neurodegenerative diseases</topic><topic>Neuroplasticity</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - therapy</topic><topic>Parkinson's disease</topic><topic>Physical training</topic><topic>Quality of life</topic><topic>Sleep</topic><topic>Substantia nigra</topic><topic>Synuclein</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feng, Ya-Shuo</creatorcontrib><creatorcontrib>Yang, Si-Dong</creatorcontrib><creatorcontrib>Tan, Zi-Xuan</creatorcontrib><creatorcontrib>Wang, Man-Man</creatorcontrib><creatorcontrib>Xing, Ying</creatorcontrib><creatorcontrib>Dong, Fang</creatorcontrib><creatorcontrib>Zhang, Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Ya-Shuo</au><au>Yang, Si-Dong</au><au>Tan, Zi-Xuan</au><au>Wang, Man-Man</au><au>Xing, Ying</au><au>Dong, Fang</au><au>Zhang, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The benefits and mechanisms of exercise training for Parkinson's disease</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2020-03-15</date><risdate>2020</risdate><volume>245</volume><spage>117345</spage><epage>10</epage><pages>117345-10</pages><artnum>117345</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Parkinson's disease (PD) is a significantly progressive neurodegenerative disease characterised by both motor and nonmotor disorders. The main pathological characteristics of PD consist of the loss of dopaminergic neurons and the formation of alpha-synuclein-containing Lewy bodies in the substantia nigra. Currently, the main therapeutic method for PD is anti-Parkinson medications, including levodopa, madopar, sirelin, and so on. However, the effect of pharmacological treatment has its own limitations, the most significant of which is that the therapeutic effect of dopaminergic treatments gradually diminishes with time. Exercise training, as an adjunctive treatment and complementary therapy, can improve the plasticity of cortical striatum and increase the release of dopamine. Exercise training has been proven to effectively improve motor disorders (including balance, gait, risk of falls and physical function) and nonmotor disorders (such as sleep impairments, cognitive function and quality of life) in PD patients. In recent years, various types of exercise training have been used to treat PD. In this review, we summarise the exercise therapy mechanisms and the protective effects of different types of exercise training on PD patients.
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| subjects | Balance Cognitive ability Disorders Dopamine Dopamine receptors Drug therapy Exercise Exercise Therapy Fitness training programs Gait Humans Levodopa Lewy bodies Motor dysfunction Movement disorders Neostriatum Neurodegenerative diseases Neuroplasticity Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Physical training Quality of life Sleep Substantia nigra Synuclein Treatment Outcome |
| title | The benefits and mechanisms of exercise training for Parkinson's disease |
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