Injectable hydrogel enables local and sustained co-delivery to the brain: Two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional recovery in rat model of stroke

Therapeutic delivery to the brain is limited by the blood-brain barrier and is exacerbated by off-target effects associated with systemic delivery, thereby precluding many potential therapies from even being tested. Given the systemic side effects of cyclosporine and erythropoietin, systemic adminis...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biomaterials 2020-03, Vol.235, p.119794-119794, Article 119794
Hauptverfasser:	Tuladhar, Anup, Obermeyer, Jaclyn M., Payne, Samantha L., Siu, Ricky C.W., Zand, Sohrab, Morshead, Cindi M., Shoichet, Molly S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Cyclosporine Drug delivery Erythropoietin Hyaluronan Hydrogels Methyl cellulose Rats Stroke - drug therapy Stroke recovery
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!