Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats

Hypertension is one of the risk factors for coronary heart disease. The present study investigated the mechanism of contractile dysfunction induced by serotonin (5-HT) in coronary artery in spontaneously hypertensive rats (SHRs). Coronary arteries were isolated form SHRs and Wistar rats. Arterial ri...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2020-11, Vol.393 (11), p.2165-2176
Hauptverfasser:	Wang, Hao, Gao, Xiao-Yan, Rao, Fang, Yang, Hui, Wang, Zhao-Yu, Liu, Lin, Kuang, Su-Juan, Wu, Qi, Deng, Chun-Yu, Xu, Jing-Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Calcium (intracellular) Calcium channels Calcium channels (L-type) Calcium channels (voltage-gated) Calcium chloride Calcium influx Cardiovascular disease Contraction Coronary artery Coronary artery disease Coronary vessels Enzyme inhibitors Heart diseases Hypertension Inositol 1,4,5-trisphosphate receptors Kinases Muscle contraction Neurosciences Nifedipine Orai1 protein Original Article Pharmacology/Toxicology Protein kinase C Protein kinase inhibitors Risk factors Rodents Serotonin Serotonin S2 receptors Signal transduction Smooth muscle STIM1 protein Vasoconstriction Veins & arteries Western blotting
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