The role of JAK/STAT signaling pathway and its inhibitors in diseases
[Display omitted] •The manuscript mainly writes the structure of JAKs and STATs.•The regulation mechanism and negative regulators of JAK/STAT signaling pathway.•Some diseases associated with the JAK/STAT pathway and JAKs inhibitors. The JAK/STAT signaling pathway is an universally expressed intracel...
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Veröffentlicht in: | International immunopharmacology 2020-03, Vol.80, p.106210-106210, Article 106210 |
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container_title | International immunopharmacology |
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creator | Xin, Ping Xu, Xiaoyun Deng, Chengjie Liu, Shuang Wang, Youzhi Zhou, Xuegang Ma, Hongxing Wei, Donghua Sun, Shiqin |
description | [Display omitted]
•The manuscript mainly writes the structure of JAKs and STATs.•The regulation mechanism and negative regulators of JAK/STAT signaling pathway.•Some diseases associated with the JAK/STAT pathway and JAKs inhibitors.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug.
The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases.
In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy. |
doi_str_mv | 10.1016/j.intimp.2020.106210 |
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•The manuscript mainly writes the structure of JAKs and STATs.•The regulation mechanism and negative regulators of JAK/STAT signaling pathway.•Some diseases associated with the JAK/STAT pathway and JAKs inhibitors.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug.
The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases.
In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2020.106210</identifier><identifier>PMID: 31972425</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Apoptosis ; Biological activity ; Cell differentiation ; Cell proliferation ; Crosstalk ; Gene expression ; Immunoregulation ; Inflammatory diseases ; Inhibitors ; Intracellular signalling ; JAK/STAT pathway and diseases ; JAK/STAT signaling pathway ; JAKs inhibitors and diseases ; Kinases ; Medical treatment ; Negative regulators ; Signal processing ; Signal transduction ; Signaling</subject><ispartof>International immunopharmacology, 2020-03, Vol.80, p.106210-106210, Article 106210</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Mar 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-13e6f7f8cbd99cc260f61a56b67e0bd7ffdbf6caae3f4e700246c8a7cad516683</citedby><cites>FETCH-LOGICAL-c456t-13e6f7f8cbd99cc260f61a56b67e0bd7ffdbf6caae3f4e700246c8a7cad516683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.intimp.2020.106210$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31972425$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xin, Ping</creatorcontrib><creatorcontrib>Xu, Xiaoyun</creatorcontrib><creatorcontrib>Deng, Chengjie</creatorcontrib><creatorcontrib>Liu, Shuang</creatorcontrib><creatorcontrib>Wang, Youzhi</creatorcontrib><creatorcontrib>Zhou, Xuegang</creatorcontrib><creatorcontrib>Ma, Hongxing</creatorcontrib><creatorcontrib>Wei, Donghua</creatorcontrib><creatorcontrib>Sun, Shiqin</creatorcontrib><title>The role of JAK/STAT signaling pathway and its inhibitors in diseases</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>[Display omitted]
•The manuscript mainly writes the structure of JAKs and STATs.•The regulation mechanism and negative regulators of JAK/STAT signaling pathway.•Some diseases associated with the JAK/STAT pathway and JAKs inhibitors.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug.
The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases.
In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.</description><subject>Apoptosis</subject><subject>Biological activity</subject><subject>Cell differentiation</subject><subject>Cell proliferation</subject><subject>Crosstalk</subject><subject>Gene expression</subject><subject>Immunoregulation</subject><subject>Inflammatory diseases</subject><subject>Inhibitors</subject><subject>Intracellular signalling</subject><subject>JAK/STAT pathway and diseases</subject><subject>JAK/STAT signaling pathway</subject><subject>JAKs inhibitors and diseases</subject><subject>Kinases</subject><subject>Medical treatment</subject><subject>Negative regulators</subject><subject>Signal processing</subject><subject>Signal transduction</subject><subject>Signaling</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMofv8DkYAXL9sm2WyyexFK8bvgwXoO2WRiU7a7Ndkq_ntTVj148DQvwzMzzIPQGSUjSqgYL0e-7f1qPWKEbVuCUbKDDmkpy4xKUuymXAiZFVJUB-goxiUhqc_pPjrIaSUZZ8Uhup4vAIeuAdw5_DB5HD_PJ3Mc_WurG9--4rXuFx_6E-vWYt9H7NuFr33fhW3E1kfQEeIJ2nO6iXD6XY_Ry831fHqXzZ5u76eTWWZ4IfqM5iCcdKWpbVUZwwRxgupC1EICqa10ztZOGK0hdxwkIYwLU2pptC2oEGV-jC6HvevQvW0g9mrlo4Gm0S10m6hYzjmTklc0oRd_0GW3CemrRHFOC5kzwRPFB8qELsYATq2DX-nwqShRW81qqQbNaqtZDZrT2Pn38k29Avs79OM1AVcDAMnGu4egovHQGrA-gOmV7fz_F74AWb2Opw</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Xin, Ping</creator><creator>Xu, Xiaoyun</creator><creator>Deng, Chengjie</creator><creator>Liu, Shuang</creator><creator>Wang, Youzhi</creator><creator>Zhou, Xuegang</creator><creator>Ma, Hongxing</creator><creator>Wei, Donghua</creator><creator>Sun, Shiqin</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>202003</creationdate><title>The role of JAK/STAT signaling pathway and its inhibitors in diseases</title><author>Xin, Ping ; Xu, Xiaoyun ; Deng, Chengjie ; Liu, Shuang ; Wang, Youzhi ; Zhou, Xuegang ; Ma, Hongxing ; Wei, Donghua ; Sun, Shiqin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-13e6f7f8cbd99cc260f61a56b67e0bd7ffdbf6caae3f4e700246c8a7cad516683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Biological activity</topic><topic>Cell differentiation</topic><topic>Cell proliferation</topic><topic>Crosstalk</topic><topic>Gene expression</topic><topic>Immunoregulation</topic><topic>Inflammatory diseases</topic><topic>Inhibitors</topic><topic>Intracellular signalling</topic><topic>JAK/STAT pathway and diseases</topic><topic>JAK/STAT signaling pathway</topic><topic>JAKs inhibitors and diseases</topic><topic>Kinases</topic><topic>Medical treatment</topic><topic>Negative regulators</topic><topic>Signal processing</topic><topic>Signal transduction</topic><topic>Signaling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xin, Ping</creatorcontrib><creatorcontrib>Xu, Xiaoyun</creatorcontrib><creatorcontrib>Deng, Chengjie</creatorcontrib><creatorcontrib>Liu, Shuang</creatorcontrib><creatorcontrib>Wang, Youzhi</creatorcontrib><creatorcontrib>Zhou, Xuegang</creatorcontrib><creatorcontrib>Ma, Hongxing</creatorcontrib><creatorcontrib>Wei, Donghua</creatorcontrib><creatorcontrib>Sun, Shiqin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xin, Ping</au><au>Xu, Xiaoyun</au><au>Deng, Chengjie</au><au>Liu, Shuang</au><au>Wang, Youzhi</au><au>Zhou, Xuegang</au><au>Ma, Hongxing</au><au>Wei, Donghua</au><au>Sun, Shiqin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of JAK/STAT signaling pathway and its inhibitors in diseases</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2020-03</date><risdate>2020</risdate><volume>80</volume><spage>106210</spage><epage>106210</epage><pages>106210-106210</pages><artnum>106210</artnum><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>[Display omitted]
•The manuscript mainly writes the structure of JAKs and STATs.•The regulation mechanism and negative regulators of JAK/STAT signaling pathway.•Some diseases associated with the JAK/STAT pathway and JAKs inhibitors.
The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression. Current researches on this pathway have been focusing on the inflammatory and neoplastic diseases and related drug.
The mechanism of JAK/STAT signaling is relatively simple. However, the biological consequences of the pathway are complicated due to its crosstalk with other signaling pathways. In addition, there is increasing evidence indicates that the persistent activation of JAK/STAT signaling pathway is closely related to many immune and inflammatory diseases, yet the specific mechanism remains unclear. Therefore, it is necessary to study the detailed mechanisms of JAK/STAT signaling in disease formation to provide critical reference for clinical treatments of the diseases.
In this review, we focus on the structure of JAKs and STATs, the JAK/STAT signaling pathway and its negative regulators, the associated diseases, and the JAK inhibitors for the clinical therapy.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31972425</pmid><doi>10.1016/j.intimp.2020.106210</doi><tpages>1</tpages></addata></record> |
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subjects | Apoptosis Biological activity Cell differentiation Cell proliferation Crosstalk Gene expression Immunoregulation Inflammatory diseases Inhibitors Intracellular signalling JAK/STAT pathway and diseases JAK/STAT signaling pathway JAKs inhibitors and diseases Kinases Medical treatment Negative regulators Signal processing Signal transduction Signaling |
title | The role of JAK/STAT signaling pathway and its inhibitors in diseases |
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