Impact of pretransplant measurable residual disease on the outcome of allogeneic hematopoietic cell transplantation in adult monosomal karyotype AML

Allogeneic hematopoietic cell transplantation (HCT) is often unsuccessful for monosomal karyotype (MK) acute myeloid leukemia (AML). To what degree failures are associated with pretransplant measurable residual disease (MRD)—a dominant adverse-risk factor—is unknown. We therefore studied 606 adults...

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Veröffentlicht in:	Leukemia 2020-06, Vol.34 (6), p.1577-1587
Hauptverfasser:	Morsink, Linde M., Othus, Megan, Bezerra, Evandro D., Wood, Brent L., Fang, Min, Sandmaier, Brenda M., Mielcarek, Marco, Schoch, Gary, Storb, Rainer, Deeg, H. Joachim, Appelbaum, Frederick R., Walter, Roland B.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990/283/1897 692/699/1541/1990/283/1897 692/700/565/2319 Abnormal Karyotype Abnormalities Acute myeloid leukemia Adolescent Adult Aged Aged, 80 and over Cancer Research Chromosomes Critical Care Medicine Cytogenetics Female Flow cytometry Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Intensive Internal Medicine Karyotypes Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - pathology Male Medical prognosis Medicine Medicine & Public Health Middle Aged Myeloid leukemia Neoplasm, Residual - mortality Neoplasm, Residual - pathology Oncology Prognosis Remission Risk analysis Risk Factors Stem cell transplantation Survival Transplantation Transplantation, Homologous Treatment Outcome Young Adult
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