Genome-wide analysis of mRNAs and lncRNAs in Mycoplasma bovis infected and non-infected bovine mammary gland tissues
Mycoplasma bovis (M. bovis) causes diseases such as arthritis, pneumonia, abortion, and mastitis, leading to great losses in the bovine dairy industries. RNA types such as messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) play significant roles in regulating the immune responses triggered by...
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| Veröffentlicht in: | Molecular and cellular probes 2020-04, Vol.50, p.101512-101512, Article 101512 |
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| description | Mycoplasma bovis (M. bovis) causes diseases such as arthritis, pneumonia, abortion, and mastitis, leading to great losses in the bovine dairy industries. RNA types such as messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) play significant roles in regulating the immune responses triggered by bacteria. The expression profiles of mRNA and lncRNA as they occur in bovine mammary gland tissues infected with M. bovis are still not well understood. To illuminate this issue, transcription analysis of mRNA and LncRNAs were conducted on the mammary gland tissues belonging to Holstein cattle infected and not infected with M. bovis. The analysis revealed 1310 differentially expressed mRNAs and 57 differentially expressed lncRNAs in the bovine mammary gland tissues infected and not infected with M. bovis. In addition, 392 novel lncRNAs were detected, 19 of which were differentially expressed. Gene ontology analysis reveals that differentially expressed mRNAs and lncRNAs play significant roles in such vital biological pathways as metabolic pathways, T-cell receptor signaling, TGF-beta signaling, pathways in cancer, PI3K-Akt signaling, NF-kappa B signaling, mTOR signaling, and apoptosis, including in the immune response to cancer. Based on our literature review, this study is the first genome-wide lncRNA research conducted on bovine mammary gland tissues infected with M. bovis. Our results provide bovine mammary gland lncRNA and mRNA resources to understand their roles in the regulation of the immune response against the agent M. bovis in bovine mammary gland tissues.
•LncRNAs and mRNAs were determined in M. bovis infected bovine mammary tissue.•1310 mRNAs and 57 IncRNAs were determined in the bovine mammary gland tissues infected and not infected with M. Bovis.•392 novel lncRNAs were detected.•Bovine mammary gland IncRNA and mRNA are important for the immune response against the agent of M. Bovis. |
| doi_str_mv | 10.1016/j.mcp.2020.101512 |
| format | Article |
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•LncRNAs and mRNAs were determined in M. bovis infected bovine mammary tissue.•1310 mRNAs and 57 IncRNAs were determined in the bovine mammary gland tissues infected and not infected with M. Bovis.•392 novel lncRNAs were detected.•Bovine mammary gland IncRNA and mRNA are important for the immune response against the agent of M. Bovis.</description><identifier>ISSN: 0890-8508</identifier><identifier>EISSN: 1096-1194</identifier><identifier>DOI: 10.1016/j.mcp.2020.101512</identifier><identifier>PMID: 31972225</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Bovine ; Cattle ; Chromosomes, Mammalian - genetics ; Cluster Analysis ; Female ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Ontology ; Genome ; Mammary gland ; Mammary Glands, Animal - metabolism ; Mammary Glands, Animal - microbiology ; Mycoplasma bovis ; Mycoplasma bovis - physiology ; Reproducibility of Results ; RNA, Long Noncoding - genetics ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA-seq</subject><ispartof>Molecular and cellular probes, 2020-04, Vol.50, p.101512-101512, Article 101512</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-8adda8afe43972d5b017983772341d7bcf2ed19d40dddb1eb6fd7dbe3e35c9193</citedby><cites>FETCH-LOGICAL-c353t-8adda8afe43972d5b017983772341d7bcf2ed19d40dddb1eb6fd7dbe3e35c9193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mcp.2020.101512$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31972225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özdemir, Selçuk</creatorcontrib><creatorcontrib>Altun, Serdar</creatorcontrib><title>Genome-wide analysis of mRNAs and lncRNAs in Mycoplasma bovis infected and non-infected bovine mammary gland tissues</title><title>Molecular and cellular probes</title><addtitle>Mol Cell Probes</addtitle><description>Mycoplasma bovis (M. bovis) causes diseases such as arthritis, pneumonia, abortion, and mastitis, leading to great losses in the bovine dairy industries. RNA types such as messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) play significant roles in regulating the immune responses triggered by bacteria. The expression profiles of mRNA and lncRNA as they occur in bovine mammary gland tissues infected with M. bovis are still not well understood. To illuminate this issue, transcription analysis of mRNA and LncRNAs were conducted on the mammary gland tissues belonging to Holstein cattle infected and not infected with M. bovis. The analysis revealed 1310 differentially expressed mRNAs and 57 differentially expressed lncRNAs in the bovine mammary gland tissues infected and not infected with M. bovis. In addition, 392 novel lncRNAs were detected, 19 of which were differentially expressed. Gene ontology analysis reveals that differentially expressed mRNAs and lncRNAs play significant roles in such vital biological pathways as metabolic pathways, T-cell receptor signaling, TGF-beta signaling, pathways in cancer, PI3K-Akt signaling, NF-kappa B signaling, mTOR signaling, and apoptosis, including in the immune response to cancer. Based on our literature review, this study is the first genome-wide lncRNA research conducted on bovine mammary gland tissues infected with M. bovis. Our results provide bovine mammary gland lncRNA and mRNA resources to understand their roles in the regulation of the immune response against the agent M. bovis in bovine mammary gland tissues.
•LncRNAs and mRNAs were determined in M. bovis infected bovine mammary tissue.•1310 mRNAs and 57 IncRNAs were determined in the bovine mammary gland tissues infected and not infected with M. Bovis.•392 novel lncRNAs were detected.•Bovine mammary gland IncRNA and mRNA are important for the immune response against the agent of M. Bovis.</description><subject>Animals</subject><subject>Bovine</subject><subject>Cattle</subject><subject>Chromosomes, Mammalian - genetics</subject><subject>Cluster Analysis</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Gene Ontology</subject><subject>Genome</subject><subject>Mammary gland</subject><subject>Mammary Glands, Animal - metabolism</subject><subject>Mammary Glands, Animal - microbiology</subject><subject>Mycoplasma bovis</subject><subject>Mycoplasma bovis - physiology</subject><subject>Reproducibility of Results</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA-seq</subject><issn>0890-8508</issn><issn>1096-1194</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAURC0EgvL4ADYoSzYpfiRNLFZVxUsqICFYW47vDXIVxyVOi_r3OG1hycr2eO54fAi5ZHTMKJvcLMbOLMec8u05Z_yAjBiVk5QxmR2SES0lTcuclifkNIQFpVRmtDwmJ4LJgnOej0j_gK13mH5bwES3utkEGxJfJ-7tZRqiAknTmu3etsnzxvhlo4PTSeXXdtBqND3C1tj6Nv0ThvsWE6ed090m-WwGR29DWGE4J0e1bgJe7Ncz8nF_9z57TOevD0-z6Tw1Ihd9WmoAXeoaMxHrQl5RVshSFAUXGYOiMjVHYBIyCgAVw2pSQwEVChS5kUyKM3K9y112_iu-2ytng8EmdkG_CirmZLxgkpbRynZW0_kQOqzVsrNDc8WoGmCrhYqw1QBb7WDHmat9_KpyCH8Tv3Sj4XZnwPjJtcVOBWOxNQi2i5QUePtP_A8G45C-</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Özdemir, Selçuk</creator><creator>Altun, Serdar</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>Genome-wide analysis of mRNAs and lncRNAs in Mycoplasma bovis infected and non-infected bovine mammary gland tissues</title><author>Özdemir, Selçuk ; Altun, Serdar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-8adda8afe43972d5b017983772341d7bcf2ed19d40dddb1eb6fd7dbe3e35c9193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Bovine</topic><topic>Cattle</topic><topic>Chromosomes, Mammalian - genetics</topic><topic>Cluster Analysis</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Gene Ontology</topic><topic>Genome</topic><topic>Mammary gland</topic><topic>Mammary Glands, Animal - metabolism</topic><topic>Mammary Glands, Animal - microbiology</topic><topic>Mycoplasma bovis</topic><topic>Mycoplasma bovis - physiology</topic><topic>Reproducibility of Results</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA-seq</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özdemir, Selçuk</creatorcontrib><creatorcontrib>Altun, Serdar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular probes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özdemir, Selçuk</au><au>Altun, Serdar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genome-wide analysis of mRNAs and lncRNAs in Mycoplasma bovis infected and non-infected bovine mammary gland tissues</atitle><jtitle>Molecular and cellular probes</jtitle><addtitle>Mol Cell Probes</addtitle><date>2020-04</date><risdate>2020</risdate><volume>50</volume><spage>101512</spage><epage>101512</epage><pages>101512-101512</pages><artnum>101512</artnum><issn>0890-8508</issn><eissn>1096-1194</eissn><abstract>Mycoplasma bovis (M. bovis) causes diseases such as arthritis, pneumonia, abortion, and mastitis, leading to great losses in the bovine dairy industries. RNA types such as messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) play significant roles in regulating the immune responses triggered by bacteria. The expression profiles of mRNA and lncRNA as they occur in bovine mammary gland tissues infected with M. bovis are still not well understood. To illuminate this issue, transcription analysis of mRNA and LncRNAs were conducted on the mammary gland tissues belonging to Holstein cattle infected and not infected with M. bovis. The analysis revealed 1310 differentially expressed mRNAs and 57 differentially expressed lncRNAs in the bovine mammary gland tissues infected and not infected with M. bovis. In addition, 392 novel lncRNAs were detected, 19 of which were differentially expressed. Gene ontology analysis reveals that differentially expressed mRNAs and lncRNAs play significant roles in such vital biological pathways as metabolic pathways, T-cell receptor signaling, TGF-beta signaling, pathways in cancer, PI3K-Akt signaling, NF-kappa B signaling, mTOR signaling, and apoptosis, including in the immune response to cancer. Based on our literature review, this study is the first genome-wide lncRNA research conducted on bovine mammary gland tissues infected with M. bovis. Our results provide bovine mammary gland lncRNA and mRNA resources to understand their roles in the regulation of the immune response against the agent M. bovis in bovine mammary gland tissues.
•LncRNAs and mRNAs were determined in M. bovis infected bovine mammary tissue.•1310 mRNAs and 57 IncRNAs were determined in the bovine mammary gland tissues infected and not infected with M. Bovis.•392 novel lncRNAs were detected.•Bovine mammary gland IncRNA and mRNA are important for the immune response against the agent of M. Bovis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31972225</pmid><doi>10.1016/j.mcp.2020.101512</doi><tpages>1</tpages></addata></record> |
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| subjects | Animals Bovine Cattle Chromosomes, Mammalian - genetics Cluster Analysis Female Gene expression Gene Expression Profiling Gene Expression Regulation Gene Ontology Genome Mammary gland Mammary Glands, Animal - metabolism Mammary Glands, Animal - microbiology Mycoplasma bovis Mycoplasma bovis - physiology Reproducibility of Results RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Messenger - metabolism RNA-seq |
| title | Genome-wide analysis of mRNAs and lncRNAs in Mycoplasma bovis infected and non-infected bovine mammary gland tissues |
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