Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation

In the present study, we report the design and synthesis of novel CAN508 sulfonamide-based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with potential CDK inhibitory activity. A bioisosteric replacement approach was adopted to replace the phenolic OH of CAN508 with...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-03, Vol.189, p.112019-112019, Article 112019
Hauptverfasser:	Said, Mohamed A., Eldehna, Wagdy M., Nocentini, Alessio, Fahim, Samar H., Bonardi, Alessandro, Elgazar, Abdullah A., Kryštof, Vladimír, Soliman, Dalia H., Abdel-Aziz, Hatem A., Gratteri, Paola, Abou-Seri, Sahar M., Supuran, Claudiu T.
Format:	Artikel
Sprache:	eng
Schlagworte:	CAN508 carbonic anhydrase inhibitors CDK inhibitors Imidazopyrazoles Molecular docking Pyrazolopyrimidines
Online-Zugang:	Volltext
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