Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on “Build-and-Scrap” Strategy

Utilizing radical chemistry, a new general C–C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthes...

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Veröffentlicht in:Organic letters 2020-02, Vol.22 (3), p.1182-1187
Hauptverfasser: Matsubara, Ryosuke, Kim, Hojin, Sakaguchi, Takaya, Xie, Weibin, Zhao, Xufeng, Nagoshi, Yuto, Wang, Chaoyu, Tateiwa, Masahiro, Ando, Akihiro, Hayashi, Masahiko, Yamanaka, Masahiro, Tsuneda, Takao
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container_end_page 1187
container_issue 3
container_start_page 1182
container_title Organic letters
container_volume 22
creator Matsubara, Ryosuke
Kim, Hojin
Sakaguchi, Takaya
Xie, Weibin
Zhao, Xufeng
Nagoshi, Yuto
Wang, Chaoyu
Tateiwa, Masahiro
Ando, Akihiro
Hayashi, Masahiko
Yamanaka, Masahiro
Tsuneda, Takao
description Utilizing radical chemistry, a new general C–C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthesis of furoxans but also short-step transformations of carboxylic acids to a broad range of functional groups.
doi_str_mv 10.1021/acs.orglett.0c00062
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title Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on “Build-and-Scrap” Strategy
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