Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals
Purposes Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies on the consumption of nanodrugs by elderly people were performed. Methods We eval...
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| Veröffentlicht in: | Pharmaceutical research 2020-03, Vol.37 (3), p.40-40, Article 40 |
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| creator | dos Reis, Sara Rhaissa Rezende Pinto, Suyene Rocha de Menezes, Frederico Duarte Martinez-Manez, Ramon Ricci-Junior, Eduardo Alencar, Luciana Magalhaes Rebelo Helal-Neto, Edward da Silva de Barros, Aline Oiveira Lisboa, Patricia Cristina Santos-Oliveira, Ralph |
| description | Purposes
Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies on the consumption of nanodrugs by elderly people were performed.
Methods
We evaluated three different nanosystems: i) carbon based nanosystem (Graphene Quantum Dots, GQD), ii) polymeric nanoparticles and mesoporous silica (magnetic core mesoporous silica, MMSN). In previous studies, our group has already characterized GQD and MMSN nanoparticles by dynamic light scattering analysis, atomic force microscopy, transmission electron microscopy, X-ray diffraction, Raman analysis, fluorescence and absorbance. The polymeric nanoparticle has been characterized by AFM and DLS. All the nanosystems were radiolabeled with 99 m-Tc by. The
in vivo
biodistribution/tissue deposition analysis evaluation was done using elder (PN270) and young (PN90) mice injected with radioactive nanosystems.
Results
The nanosystems used in this study were well-formed as the radiolabeling processes were stable. Biodistribution analysis showed that there is a decrease in the uptake of the nanoparticles in elder mice when compared to young mice, showing that is necessary to increase the initial dose in elder people to achieve the same concentration when compared to young animals.
Conclusion
The discrepancy on tissue distribution of nanosystems between young and elder individuals must be monitored, as the therapeutic effect will be different in the groups. Noteworthy, this data is an alarm that some specific conditions must be evaluated before commercialization of nano-drugs.
Graphical Abstract
Changes between younger and elderly individuals are undoubtedly, especially in drug tissue deposition, biodistribution and pharmacokinetics. The same thought should be applied to nanoparticles. A comprehensive analysis on how age discrepancy change the biological behavior of nanoparticles has been performed. |
| doi_str_mv | 10.1007/s11095-019-2754-9 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2344230429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A747439169</galeid><sourcerecordid>A747439169</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-78fabc039c67838971c2e6ad8494a7aed021ab966f3f602347cca67cb5c6ac6f3</originalsourceid><addsrcrecordid>eNp1Uk1v1DAQjRCILoUfwAVZ4sKBFDvxxjG3bbeUSi0fapHgZHmdydZVYgfbOexv5k8waVqqIpAPI8-89_w8eln2ktEDRql4FxmjcplTJvNCLHkuH2ULthRlLin__jhbUFHwvBac7WXPYrymlNZM8qfZXsmkoFzKRfbrAhxEA84A0a4h6QrIaT9ok4h35ND6xsYU7GZMFu--JWvbthDAJfJJOx93MUEf39_w1jaaAIN2ZjeRL22MI3Zh8NHe0U-CHq7wSfJ11C6NPVn7FN-SL77bGT0E3-HLHseT-KBDsqabjZ3rrQO8knOIfvDBj5Fc2M4a_QAbiXXkhx_d9oZ13DUQyMrZXnfxefakxQIvbut-9u3D8eXRx_zs88np0eosN7yUKRd1qzeGltJUoi5rKZgpoNJNzSXXQkNDC6Y3sqrasq1oUXJhjK6E2SxNpQ1297M3sy7-5-cIMakeNwNdpx2gbYUUXpSUFxKhr_-CXvsxOHQ3ocpSVrKi96it7kBZ1_oUtJlE1Upwga5ZNWkd_AOFp4HeGlxqa7H_gMBmggk-xgCtGgIuKuwUo2oKmJoDpjBgagqYmjivbg2Pmx6aP4y7RCGgmAERR24L4f5H_1f9DQEi33w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2343396960</pqid></control><display><type>article</type><title>Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>dos Reis, Sara Rhaissa Rezende ; Pinto, Suyene Rocha ; de Menezes, Frederico Duarte ; Martinez-Manez, Ramon ; Ricci-Junior, Eduardo ; Alencar, Luciana Magalhaes Rebelo ; Helal-Neto, Edward ; da Silva de Barros, Aline Oiveira ; Lisboa, Patricia Cristina ; Santos-Oliveira, Ralph</creator><creatorcontrib>dos Reis, Sara Rhaissa Rezende ; Pinto, Suyene Rocha ; de Menezes, Frederico Duarte ; Martinez-Manez, Ramon ; Ricci-Junior, Eduardo ; Alencar, Luciana Magalhaes Rebelo ; Helal-Neto, Edward ; da Silva de Barros, Aline Oiveira ; Lisboa, Patricia Cristina ; Santos-Oliveira, Ralph</creatorcontrib><description>Purposes
Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies on the consumption of nanodrugs by elderly people were performed.
Methods
We evaluated three different nanosystems: i) carbon based nanosystem (Graphene Quantum Dots, GQD), ii) polymeric nanoparticles and mesoporous silica (magnetic core mesoporous silica, MMSN). In previous studies, our group has already characterized GQD and MMSN nanoparticles by dynamic light scattering analysis, atomic force microscopy, transmission electron microscopy, X-ray diffraction, Raman analysis, fluorescence and absorbance. The polymeric nanoparticle has been characterized by AFM and DLS. All the nanosystems were radiolabeled with 99 m-Tc by. The
in vivo
biodistribution/tissue deposition analysis evaluation was done using elder (PN270) and young (PN90) mice injected with radioactive nanosystems.
Results
The nanosystems used in this study were well-formed as the radiolabeling processes were stable. Biodistribution analysis showed that there is a decrease in the uptake of the nanoparticles in elder mice when compared to young mice, showing that is necessary to increase the initial dose in elder people to achieve the same concentration when compared to young animals.
Conclusion
The discrepancy on tissue distribution of nanosystems between young and elder individuals must be monitored, as the therapeutic effect will be different in the groups. Noteworthy, this data is an alarm that some specific conditions must be evaluated before commercialization of nano-drugs.
Graphical Abstract
Changes between younger and elderly individuals are undoubtedly, especially in drug tissue deposition, biodistribution and pharmacokinetics. The same thought should be applied to nanoparticles. A comprehensive analysis on how age discrepancy change the biological behavior of nanoparticles has been performed.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1007/s11095-019-2754-9</identifier><identifier>PMID: 31970499</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Age Factors ; Aging ; Analysis ; Animals ; Atomic force microscopy ; Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Bone density ; Bones ; Commercialization ; Density ; Diffraction ; Fluorescence ; Geriatrics ; Graphene ; Graphite - chemistry ; Isotope Labeling ; Light scattering ; Magnetic cores ; Magnetite Nanoparticles - chemistry ; Medical Law ; Mice ; Microscopy ; Models, Animal ; Muscles ; Nanoparticles ; Nanoparticles - administration & dosage ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Older people ; Particle Size ; Pharmacology/Toxicology ; Pharmacy ; Photon correlation spectroscopy ; Polycaprolactone ; Polyesters - chemistry ; Porosity ; Quantum dots ; Research Paper ; Senescence ; Silica ; Silicon Dioxide - chemistry ; Surface Properties ; Technetium - chemistry ; Tissue analysis ; Tissue Distribution ; Tissues ; Transmission electron microscopy ; X-ray diffraction ; X-rays</subject><ispartof>Pharmaceutical research, 2020-03, Vol.37 (3), p.40-40, Article 40</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Pharmaceutical Research is a copyright of Springer, (2020). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-78fabc039c67838971c2e6ad8494a7aed021ab966f3f602347cca67cb5c6ac6f3</citedby><cites>FETCH-LOGICAL-c439t-78fabc039c67838971c2e6ad8494a7aed021ab966f3f602347cca67cb5c6ac6f3</cites><orcidid>0000-0002-0905-481X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11095-019-2754-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11095-019-2754-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31970499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>dos Reis, Sara Rhaissa Rezende</creatorcontrib><creatorcontrib>Pinto, Suyene Rocha</creatorcontrib><creatorcontrib>de Menezes, Frederico Duarte</creatorcontrib><creatorcontrib>Martinez-Manez, Ramon</creatorcontrib><creatorcontrib>Ricci-Junior, Eduardo</creatorcontrib><creatorcontrib>Alencar, Luciana Magalhaes Rebelo</creatorcontrib><creatorcontrib>Helal-Neto, Edward</creatorcontrib><creatorcontrib>da Silva de Barros, Aline Oiveira</creatorcontrib><creatorcontrib>Lisboa, Patricia Cristina</creatorcontrib><creatorcontrib>Santos-Oliveira, Ralph</creatorcontrib><title>Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><addtitle>Pharm Res</addtitle><description>Purposes
Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies on the consumption of nanodrugs by elderly people were performed.
Methods
We evaluated three different nanosystems: i) carbon based nanosystem (Graphene Quantum Dots, GQD), ii) polymeric nanoparticles and mesoporous silica (magnetic core mesoporous silica, MMSN). In previous studies, our group has already characterized GQD and MMSN nanoparticles by dynamic light scattering analysis, atomic force microscopy, transmission electron microscopy, X-ray diffraction, Raman analysis, fluorescence and absorbance. The polymeric nanoparticle has been characterized by AFM and DLS. All the nanosystems were radiolabeled with 99 m-Tc by. The
in vivo
biodistribution/tissue deposition analysis evaluation was done using elder (PN270) and young (PN90) mice injected with radioactive nanosystems.
Results
The nanosystems used in this study were well-formed as the radiolabeling processes were stable. Biodistribution analysis showed that there is a decrease in the uptake of the nanoparticles in elder mice when compared to young mice, showing that is necessary to increase the initial dose in elder people to achieve the same concentration when compared to young animals.
Conclusion
The discrepancy on tissue distribution of nanosystems between young and elder individuals must be monitored, as the therapeutic effect will be different in the groups. Noteworthy, this data is an alarm that some specific conditions must be evaluated before commercialization of nano-drugs.
Graphical Abstract
Changes between younger and elderly individuals are undoubtedly, especially in drug tissue deposition, biodistribution and pharmacokinetics. The same thought should be applied to nanoparticles. A comprehensive analysis on how age discrepancy change the biological behavior of nanoparticles has been performed.</description><subject>Age Factors</subject><subject>Aging</subject><subject>Analysis</subject><subject>Animals</subject><subject>Atomic force microscopy</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Bone density</subject><subject>Bones</subject><subject>Commercialization</subject><subject>Density</subject><subject>Diffraction</subject><subject>Fluorescence</subject><subject>Geriatrics</subject><subject>Graphene</subject><subject>Graphite - chemistry</subject><subject>Isotope Labeling</subject><subject>Light scattering</subject><subject>Magnetic cores</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Medical Law</subject><subject>Mice</subject><subject>Microscopy</subject><subject>Models, Animal</subject><subject>Muscles</subject><subject>Nanoparticles</subject><subject>Nanoparticles - administration & dosage</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Older people</subject><subject>Particle Size</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Photon correlation spectroscopy</subject><subject>Polycaprolactone</subject><subject>Polyesters - chemistry</subject><subject>Porosity</subject><subject>Quantum dots</subject><subject>Research Paper</subject><subject>Senescence</subject><subject>Silica</subject><subject>Silicon Dioxide - chemistry</subject><subject>Surface Properties</subject><subject>Technetium - chemistry</subject><subject>Tissue analysis</subject><subject>Tissue Distribution</subject><subject>Tissues</subject><subject>Transmission electron microscopy</subject><subject>X-ray diffraction</subject><subject>X-rays</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1Uk1v1DAQjRCILoUfwAVZ4sKBFDvxxjG3bbeUSi0fapHgZHmdydZVYgfbOexv5k8waVqqIpAPI8-89_w8eln2ktEDRql4FxmjcplTJvNCLHkuH2ULthRlLin__jhbUFHwvBac7WXPYrymlNZM8qfZXsmkoFzKRfbrAhxEA84A0a4h6QrIaT9ok4h35ND6xsYU7GZMFu--JWvbthDAJfJJOx93MUEf39_w1jaaAIN2ZjeRL22MI3Zh8NHe0U-CHq7wSfJ11C6NPVn7FN-SL77bGT0E3-HLHseT-KBDsqabjZ3rrQO8knOIfvDBj5Fc2M4a_QAbiXXkhx_d9oZ13DUQyMrZXnfxefakxQIvbut-9u3D8eXRx_zs88np0eosN7yUKRd1qzeGltJUoi5rKZgpoNJNzSXXQkNDC6Y3sqrasq1oUXJhjK6E2SxNpQ1297M3sy7-5-cIMakeNwNdpx2gbYUUXpSUFxKhr_-CXvsxOHQ3ocpSVrKi96it7kBZ1_oUtJlE1Upwga5ZNWkd_AOFp4HeGlxqa7H_gMBmggk-xgCtGgIuKuwUo2oKmJoDpjBgagqYmjivbg2Pmx6aP4y7RCGgmAERR24L4f5H_1f9DQEi33w</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>dos Reis, Sara Rhaissa Rezende</creator><creator>Pinto, Suyene Rocha</creator><creator>de Menezes, Frederico Duarte</creator><creator>Martinez-Manez, Ramon</creator><creator>Ricci-Junior, Eduardo</creator><creator>Alencar, Luciana Magalhaes Rebelo</creator><creator>Helal-Neto, Edward</creator><creator>da Silva de Barros, Aline Oiveira</creator><creator>Lisboa, Patricia Cristina</creator><creator>Santos-Oliveira, Ralph</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0905-481X</orcidid></search><sort><creationdate>20200301</creationdate><title>Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals</title><author>dos Reis, Sara Rhaissa Rezende ; Pinto, Suyene Rocha ; de Menezes, Frederico Duarte ; Martinez-Manez, Ramon ; Ricci-Junior, Eduardo ; Alencar, Luciana Magalhaes Rebelo ; Helal-Neto, Edward ; da Silva de Barros, Aline Oiveira ; Lisboa, Patricia Cristina ; Santos-Oliveira, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-78fabc039c67838971c2e6ad8494a7aed021ab966f3f602347cca67cb5c6ac6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age Factors</topic><topic>Aging</topic><topic>Analysis</topic><topic>Animals</topic><topic>Atomic force microscopy</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedicine</topic><topic>Bone density</topic><topic>Bones</topic><topic>Commercialization</topic><topic>Density</topic><topic>Diffraction</topic><topic>Fluorescence</topic><topic>Geriatrics</topic><topic>Graphene</topic><topic>Graphite - chemistry</topic><topic>Isotope Labeling</topic><topic>Light scattering</topic><topic>Magnetic cores</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Medical Law</topic><topic>Mice</topic><topic>Microscopy</topic><topic>Models, Animal</topic><topic>Muscles</topic><topic>Nanoparticles</topic><topic>Nanoparticles - administration & dosage</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - metabolism</topic><topic>Older people</topic><topic>Particle Size</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Photon correlation spectroscopy</topic><topic>Polycaprolactone</topic><topic>Polyesters - chemistry</topic><topic>Porosity</topic><topic>Quantum dots</topic><topic>Research Paper</topic><topic>Senescence</topic><topic>Silica</topic><topic>Silicon Dioxide - chemistry</topic><topic>Surface Properties</topic><topic>Technetium - chemistry</topic><topic>Tissue analysis</topic><topic>Tissue Distribution</topic><topic>Tissues</topic><topic>Transmission electron microscopy</topic><topic>X-ray diffraction</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>dos Reis, Sara Rhaissa Rezende</creatorcontrib><creatorcontrib>Pinto, Suyene Rocha</creatorcontrib><creatorcontrib>de Menezes, Frederico Duarte</creatorcontrib><creatorcontrib>Martinez-Manez, Ramon</creatorcontrib><creatorcontrib>Ricci-Junior, Eduardo</creatorcontrib><creatorcontrib>Alencar, Luciana Magalhaes Rebelo</creatorcontrib><creatorcontrib>Helal-Neto, Edward</creatorcontrib><creatorcontrib>da Silva de Barros, Aline Oiveira</creatorcontrib><creatorcontrib>Lisboa, Patricia Cristina</creatorcontrib><creatorcontrib>Santos-Oliveira, Ralph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>dos Reis, Sara Rhaissa Rezende</au><au>Pinto, Suyene Rocha</au><au>de Menezes, Frederico Duarte</au><au>Martinez-Manez, Ramon</au><au>Ricci-Junior, Eduardo</au><au>Alencar, Luciana Magalhaes Rebelo</au><au>Helal-Neto, Edward</au><au>da Silva de Barros, Aline Oiveira</au><au>Lisboa, Patricia Cristina</au><au>Santos-Oliveira, Ralph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals</atitle><jtitle>Pharmaceutical research</jtitle><stitle>Pharm Res</stitle><addtitle>Pharm Res</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>37</volume><issue>3</issue><spage>40</spage><epage>40</epage><pages>40-40</pages><artnum>40</artnum><issn>0724-8741</issn><eissn>1573-904X</eissn><abstract>Purposes
Senescence is an inevitable and irreversible process, which may lead to loss in muscle and bone density, decline in brain volume and loss in renal clearance. Although aging is a well-known process, few studies on the consumption of nanodrugs by elderly people were performed.
Methods
We evaluated three different nanosystems: i) carbon based nanosystem (Graphene Quantum Dots, GQD), ii) polymeric nanoparticles and mesoporous silica (magnetic core mesoporous silica, MMSN). In previous studies, our group has already characterized GQD and MMSN nanoparticles by dynamic light scattering analysis, atomic force microscopy, transmission electron microscopy, X-ray diffraction, Raman analysis, fluorescence and absorbance. The polymeric nanoparticle has been characterized by AFM and DLS. All the nanosystems were radiolabeled with 99 m-Tc by. The
in vivo
biodistribution/tissue deposition analysis evaluation was done using elder (PN270) and young (PN90) mice injected with radioactive nanosystems.
Results
The nanosystems used in this study were well-formed as the radiolabeling processes were stable. Biodistribution analysis showed that there is a decrease in the uptake of the nanoparticles in elder mice when compared to young mice, showing that is necessary to increase the initial dose in elder people to achieve the same concentration when compared to young animals.
Conclusion
The discrepancy on tissue distribution of nanosystems between young and elder individuals must be monitored, as the therapeutic effect will be different in the groups. Noteworthy, this data is an alarm that some specific conditions must be evaluated before commercialization of nano-drugs.
Graphical Abstract
Changes between younger and elderly individuals are undoubtedly, especially in drug tissue deposition, biodistribution and pharmacokinetics. The same thought should be applied to nanoparticles. A comprehensive analysis on how age discrepancy change the biological behavior of nanoparticles has been performed.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31970499</pmid><doi>10.1007/s11095-019-2754-9</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0905-481X</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0724-8741 |
| ispartof | Pharmaceutical research, 2020-03, Vol.37 (3), p.40-40, Article 40 |
| issn | 0724-8741 1573-904X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2344230429 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Age Factors Aging Analysis Animals Atomic force microscopy Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Bone density Bones Commercialization Density Diffraction Fluorescence Geriatrics Graphene Graphite - chemistry Isotope Labeling Light scattering Magnetic cores Magnetite Nanoparticles - chemistry Medical Law Mice Microscopy Models, Animal Muscles Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoparticles - metabolism Older people Particle Size Pharmacology/Toxicology Pharmacy Photon correlation spectroscopy Polycaprolactone Polyesters - chemistry Porosity Quantum dots Research Paper Senescence Silica Silicon Dioxide - chemistry Surface Properties Technetium - chemistry Tissue analysis Tissue Distribution Tissues Transmission electron microscopy X-ray diffraction X-rays |
| title | Senescence and the Impact on Biodistribution of Different Nanosystems: the Discrepancy on Tissue Deposition of Graphene Quantum Dots, Polycaprolactone Nanoparticle and Magnetic Mesoporous Silica Nanoparticles in Young and Elder Animals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T22%3A41%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Senescence%20and%20the%20Impact%20on%20Biodistribution%20of%20Different%20Nanosystems:%20the%20Discrepancy%20on%20Tissue%20Deposition%20of%20Graphene%20Quantum%20Dots,%20Polycaprolactone%20Nanoparticle%20and%20Magnetic%20Mesoporous%20Silica%20Nanoparticles%20in%20Young%20and%20Elder%20Animals&rft.jtitle=Pharmaceutical%20research&rft.au=dos%20Reis,%20Sara%20Rhaissa%20Rezende&rft.date=2020-03-01&rft.volume=37&rft.issue=3&rft.spage=40&rft.epage=40&rft.pages=40-40&rft.artnum=40&rft.issn=0724-8741&rft.eissn=1573-904X&rft_id=info:doi/10.1007/s11095-019-2754-9&rft_dat=%3Cgale_proqu%3EA747439169%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2343396960&rft_id=info:pmid/31970499&rft_galeid=A747439169&rfr_iscdi=true |