Development of a novel monoclonal antibody that binds to most HLA-A allomorphs in a conformation-dependent yet peptide-promiscuous fashion

Specificity analyses of peptide binding to human leukocyte antigen (HLA)-A molecules have been hampered due to a lack of proper monoclonal antibodies (mAbs) for certain allomorphs, such as the prevalent HLA-A1 for Caucasians and HLA-A11 for Asians. We developed a mAb that recognizes a conformational...

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Veröffentlicht in:	Immunogenetics (New York) 2020-04, Vol.72 (3), p.143-153
Hauptverfasser:	Komatsu, Toshihiro, Shimizu, Takeyuki, Kanoh, Makoto, Miyakawa, Tomoya, Satta, Yoko, Yasukochi, Yoshiki, Fujimoto, Rika, Tada, Motoki, Machida, Kaori, Kataoka, Sayo, Udaka, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergology Amino Acid Sequence Amino acids Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antigens Bifurcations Binding Biological evolution Biomedical and Life Sciences Biomedicine Cell Biology Cell Line, Tumor Cell lines Computer applications Conformation Epitopes Epitopes - immunology Evolutionary genetics Gene expression Gene Function Histocompatibility antigen HLA HLA-A Antigens - chemistry HLA-A Antigens - immunology HLA-A1 Antigen - chemistry HLA-A1 Antigen - immunology Human Genetics Humans Immunology Leukocytes Loci Medical research Models, Molecular Monoclonal antibodies Original Article Peptides Peptides - immunology Protein Binding - immunology Protein Conformation Software
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