Furanone quorum-sensing inhibitors with potential as novel therapeutics against Pseudomonas aeruginosa

Micro-organisms use quorum sensing (QS), a cell density-dependent process, to communicate. This QS mode of interchange leads to the production of a variety of virulence factors, co-ordination of complex bacterial behaviours, such as swarming motility, degradation of host tissue and biofilm formation...

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Veröffentlicht in:	Journal of medical microbiology 2020-02, Vol.69 (2), p.195-206
Hauptverfasser:	Proctor, Chris R, McCarron, Paul A, Ternan, Nigel G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - chemistry Furans - administration & dosage Furans - chemistry Humans Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - physiology Pseudomonas Infections - drug therapy Pseudomonas Infections - microbiology Quorum Sensing - drug effects
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