Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility

TLR3 mediates skin solar injury by binding nuclear material released from apoptotic keratinocytes, resulting in the production of pro-inflammatory cytokines. Because the TLR3 gene is located in 4q35, a known systemic lupus erythematosus (SLE) susceptibility locus, we wondered whether TLR3 single nuc...

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Veröffentlicht in:	Clinical and experimental rheumatology 2020-09, Vol.38 (5), p.881-890
Hauptverfasser:	De Groof, Aurélie, Ducreux, Julie, Vidal-Bralo, Laura, Tyteca, Donatienne, Galant, Christine, Marot, Liliane, Coulie, Pierre G, Van den Eynde, Benoît J, Rodriguez-Martinez, Lorena, Santos, Maria Jose, Suarez, Ana, Carreira, Patricia, Marchini, Maurizio, Gonzàlez, Antonio, Houssiau, Frédéric A, Lauwerys, Bernard R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Presenting Cells Apoptosis Genetic Predisposition to Disease HEK293 Cells Humans Lupus Erythematosus, Systemic - genetics Polymorphism, Single Nucleotide Toll-Like Receptor 3 - genetics
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