Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence against bacterial and fungal infections. However, neutrophils also contribute to tissue damage during various autoimmune and inflammatory diseases, and play important roles in cancer progression. The intimate b...
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| Veröffentlicht in: | Nature reviews. Drug discovery 2020-04, Vol.19 (4), p.253-275 |
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| creator | Németh, Tamás Sperandio, Markus Mócsai, Attila |
| description | Neutrophils are the most abundant circulating leukocytes, being the first line of defence against bacterial and fungal infections. However, neutrophils also contribute to tissue damage during various autoimmune and inflammatory diseases, and play important roles in cancer progression. The intimate but complex involvement of neutrophils in various diseases makes them exciting targets for therapeutic intervention but also necessitates differentiation of beneficial responses from potentially detrimental side effects. A variety of approaches to therapeutically target neutrophils have emerged, including strategies to enhance, inhibit or restore neutrophil function, with several agents entering clinical trials. However, challenges and controversies in the field remain.
Neutrophils play diverse roles in various disease processes, including infection, pulmonary diseases, autoimmune and inflammatory disorders, cardiovascular diseases and cancer. Here, Mócsai and colleagues provide an overview of the biological and pathological functions of neutrophils, assessing emerging strategies to therapeutically target neutrophils and agents currently under investigation. |
| doi_str_mv | 10.1038/s41573-019-0054-z |
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Neutrophils play diverse roles in various disease processes, including infection, pulmonary diseases, autoimmune and inflammatory disorders, cardiovascular diseases and cancer. 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Drug discovery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Németh, Tamás</au><au>Sperandio, Markus</au><au>Mócsai, Attila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophils as emerging therapeutic targets</atitle><jtitle>Nature reviews. Drug discovery</jtitle><stitle>Nat Rev Drug Discov</stitle><addtitle>Nat Rev Drug Discov</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>19</volume><issue>4</issue><spage>253</spage><epage>275</epage><pages>253-275</pages><issn>1474-1776</issn><eissn>1474-1784</eissn><abstract>Neutrophils are the most abundant circulating leukocytes, being the first line of defence against bacterial and fungal infections. However, neutrophils also contribute to tissue damage during various autoimmune and inflammatory diseases, and play important roles in cancer progression. The intimate but complex involvement of neutrophils in various diseases makes them exciting targets for therapeutic intervention but also necessitates differentiation of beneficial responses from potentially detrimental side effects. A variety of approaches to therapeutically target neutrophils have emerged, including strategies to enhance, inhibit or restore neutrophil function, with several agents entering clinical trials. However, challenges and controversies in the field remain.
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| subjects | 631/154 631/250/249/1313 631/250/2504/223/1699 631/250/255 631/67 692/699/75 Animals Autoimmune Diseases - immunology Bacterial infections Biomedical and Life Sciences Biomedicine Biotechnology Cancer Research Congenital diseases Cytokines Drug targeting Drug therapy Forecasts and trends Health aspects Homeostasis Humans Infections Inflammation Inflammation - immunology Kinases Leukocytes - immunology Lupus Medicinal Chemistry Molecular Medicine Mutation Neutropenia Neutrophils Neutrophils - immunology Pathogenesis Pharmacology/Toxicology Review Article Rheumatoid arthritis Trends |
| title | Neutrophils as emerging therapeutic targets |
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