EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER
Radiotherapy with radioactive iodine (RAI) has become a common treatment for postsurgical differentiated thyroid carcinoma (DTC). The objective of this study was to determine the effect of RAI therapy following surgery on the function of the parathyroid glands in DTC patients. A total of 81 DTC pati...
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| Veröffentlicht in: | Endocrine practice 2020-04, Vol.26 (4), p.416-422 |
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| creator | Zhang, Aimi Li, Panli Liu, Qiufang Peng, Shiyao Huang, Gang Song, Shaoli |
| description | Radiotherapy with radioactive iodine (RAI) has become a common treatment for postsurgical differentiated thyroid carcinoma (DTC). The objective of this study was to determine the effect of RAI therapy following surgery on the function of the parathyroid glands in DTC patients.
A total of 81 DTC patients who received RAI therapy after surgery were enrolled in the study. The size of the residual thyroid was detected by technetium-99m (
Tc)-pertechnetate thyroid scan (
Tc thyroid scan) before RAI therapy. The iodine uptake ability of residual thyroid was evaluated by iodine-131 (
I) whole-body scan (WBS). All patients were treated with an activity of 3.7 GBq (100 mCi)
I. Parathyroid hormone (PTH), serum calcium, phosphorus, and magnesium were evaluated at 1 day before treatment, and at 1 month and 3 months after treatment.
The results show that there was no statistically significant difference in blood PTH level observed (
>.05) between 3 time points (pre-treatment, 1 month post-treatment and 3 months post-treatment). The serum calcium and phosphorus did not change significantly (
>.05), but serum magnesium level was elevated after treatment ( |
| doi_str_mv | 10.4158/EP-2019-0398 |
| format | Article |
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A total of 81 DTC patients who received RAI therapy after surgery were enrolled in the study. The size of the residual thyroid was detected by technetium-99m (
Tc)-pertechnetate thyroid scan (
Tc thyroid scan) before RAI therapy. The iodine uptake ability of residual thyroid was evaluated by iodine-131 (
I) whole-body scan (WBS). All patients were treated with an activity of 3.7 GBq (100 mCi)
I. Parathyroid hormone (PTH), serum calcium, phosphorus, and magnesium were evaluated at 1 day before treatment, and at 1 month and 3 months after treatment.
The results show that there was no statistically significant difference in blood PTH level observed (
>.05) between 3 time points (pre-treatment, 1 month post-treatment and 3 months post-treatment). The serum calcium and phosphorus did not change significantly (
>.05), but serum magnesium level was elevated after treatment (
<.05). There were no significant differences between PTH changes and sex, age, scores of
Tc thyroid scan, scores of
I WBS, Tumor (T) stage, and Node (N) stage.
RAI therapy following surgery did not significantly affect parathyroid function in DTC patients.
= American Thyroid Association;
= differentiated thyroid carcinoma;
= free triiodothyronine;
= free thyroxine;
= iodine-131;
= parathyroid hormone;
= radioiodine;
= Technetium-99m;
= thyroglobulin;
= Tumor Node Metastasis;
= thyroid-stimulating hormone;
= whole-body scan.</description><identifier>ISSN: 1530-891X</identifier><identifier>EISSN: 1934-2403</identifier><identifier>DOI: 10.4158/EP-2019-0398</identifier><identifier>PMID: 31968192</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Cancer therapies ; Combined Modality Therapy ; Humans ; Immunoassay ; Iodine ; Iodine Radioisotopes ; Males ; Parathyroid Glands ; Patients ; Phosphorus ; Software ; Studies ; Thyroglobulin ; Thyroid cancer ; Thyroid Neoplasms - radiotherapy ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Tomography, X-Ray Computed</subject><ispartof>Endocrine practice, 2020-04, Vol.26 (4), p.416-422</ispartof><rights>Copyright Allen Press Publishing Services Apr 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-b32fa8e349bafc13e06271758f832eff3c198ac3129be826b7e1df96842105a43</citedby><cites>FETCH-LOGICAL-c319t-b32fa8e349bafc13e06271758f832eff3c198ac3129be826b7e1df96842105a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2389778085?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31968192$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Aimi</creatorcontrib><creatorcontrib>Li, Panli</creatorcontrib><creatorcontrib>Liu, Qiufang</creatorcontrib><creatorcontrib>Peng, Shiyao</creatorcontrib><creatorcontrib>Huang, Gang</creatorcontrib><creatorcontrib>Song, Shaoli</creatorcontrib><title>EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER</title><title>Endocrine practice</title><addtitle>Endocr Pract</addtitle><description>Radiotherapy with radioactive iodine (RAI) has become a common treatment for postsurgical differentiated thyroid carcinoma (DTC). The objective of this study was to determine the effect of RAI therapy following surgery on the function of the parathyroid glands in DTC patients.
A total of 81 DTC patients who received RAI therapy after surgery were enrolled in the study. The size of the residual thyroid was detected by technetium-99m (
Tc)-pertechnetate thyroid scan (
Tc thyroid scan) before RAI therapy. The iodine uptake ability of residual thyroid was evaluated by iodine-131 (
I) whole-body scan (WBS). All patients were treated with an activity of 3.7 GBq (100 mCi)
I. Parathyroid hormone (PTH), serum calcium, phosphorus, and magnesium were evaluated at 1 day before treatment, and at 1 month and 3 months after treatment.
The results show that there was no statistically significant difference in blood PTH level observed (
>.05) between 3 time points (pre-treatment, 1 month post-treatment and 3 months post-treatment). The serum calcium and phosphorus did not change significantly (
>.05), but serum magnesium level was elevated after treatment (
<.05). There were no significant differences between PTH changes and sex, age, scores of
Tc thyroid scan, scores of
I WBS, Tumor (T) stage, and Node (N) stage.
RAI therapy following surgery did not significantly affect parathyroid function in DTC patients.
= American Thyroid Association;
= differentiated thyroid carcinoma;
= free triiodothyronine;
= free thyroxine;
= iodine-131;
= parathyroid hormone;
= radioiodine;
= Technetium-99m;
= thyroglobulin;
= Tumor Node Metastasis;
= thyroid-stimulating hormone;
= whole-body scan.</description><subject>Cancer therapies</subject><subject>Combined Modality Therapy</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Iodine</subject><subject>Iodine Radioisotopes</subject><subject>Males</subject><subject>Parathyroid Glands</subject><subject>Patients</subject><subject>Phosphorus</subject><subject>Software</subject><subject>Studies</subject><subject>Thyroglobulin</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - radiotherapy</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Tomography, X-Ray Computed</subject><issn>1530-891X</issn><issn>1934-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkTtPwzAUhS0EolDYmJElFgYCfuRhj1HqEEtVEqWuoFOUpI7Uqm1K0gz8exzaMjBd36PPx9f3APCA0auNHfYmUosgzC1EObsAN5hT2yI2opfm7FBkMY4_R-C269YIEcQxuwYjirnLMCc3YC3CUAQKJiFMk5myZvPsXQb-FGa-hCoSmZ8uYBLD1M98FS2yRE5gOI8DJY0oB11JEasZ_JAqghNp3DLTS1-JCTxfCPw4ENkduKqLTafvT3UM5qFQQWRNk98nrcqMdbBKSuqCaWrzsqgrTDVyiYc9h9WMEl3XtMKcFYYlvNSMuKWn8bI2_7EJRk5h0zF4Pvru2-ar190h3666Sm82xU43fZcTatvEbMjFBn36h66bvt2Z6QzFuOcxxBxDvRypqm26rtV1vm9X26L9zjHKhwxykeZDBvmQgcEfT6Z9udXLP_i8dPoDddZ2yA</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Zhang, Aimi</creator><creator>Li, Panli</creator><creator>Liu, Qiufang</creator><creator>Peng, Shiyao</creator><creator>Huang, Gang</creator><creator>Song, Shaoli</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>202004</creationdate><title>EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER</title><author>Zhang, Aimi ; Li, Panli ; Liu, Qiufang ; Peng, Shiyao ; Huang, Gang ; Song, Shaoli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-b32fa8e349bafc13e06271758f832eff3c198ac3129be826b7e1df96842105a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer therapies</topic><topic>Combined Modality Therapy</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Iodine</topic><topic>Iodine Radioisotopes</topic><topic>Males</topic><topic>Parathyroid Glands</topic><topic>Patients</topic><topic>Phosphorus</topic><topic>Software</topic><topic>Studies</topic><topic>Thyroglobulin</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - radiotherapy</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Aimi</creatorcontrib><creatorcontrib>Li, Panli</creatorcontrib><creatorcontrib>Liu, Qiufang</creatorcontrib><creatorcontrib>Peng, Shiyao</creatorcontrib><creatorcontrib>Huang, Gang</creatorcontrib><creatorcontrib>Song, Shaoli</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Aimi</au><au>Li, Panli</au><au>Liu, Qiufang</au><au>Peng, Shiyao</au><au>Huang, Gang</au><au>Song, Shaoli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER</atitle><jtitle>Endocrine practice</jtitle><addtitle>Endocr Pract</addtitle><date>2020-04</date><risdate>2020</risdate><volume>26</volume><issue>4</issue><spage>416</spage><epage>422</epage><pages>416-422</pages><issn>1530-891X</issn><eissn>1934-2403</eissn><abstract>Radiotherapy with radioactive iodine (RAI) has become a common treatment for postsurgical differentiated thyroid carcinoma (DTC). The objective of this study was to determine the effect of RAI therapy following surgery on the function of the parathyroid glands in DTC patients.
A total of 81 DTC patients who received RAI therapy after surgery were enrolled in the study. The size of the residual thyroid was detected by technetium-99m (
Tc)-pertechnetate thyroid scan (
Tc thyroid scan) before RAI therapy. The iodine uptake ability of residual thyroid was evaluated by iodine-131 (
I) whole-body scan (WBS). All patients were treated with an activity of 3.7 GBq (100 mCi)
I. Parathyroid hormone (PTH), serum calcium, phosphorus, and magnesium were evaluated at 1 day before treatment, and at 1 month and 3 months after treatment.
The results show that there was no statistically significant difference in blood PTH level observed (
>.05) between 3 time points (pre-treatment, 1 month post-treatment and 3 months post-treatment). The serum calcium and phosphorus did not change significantly (
>.05), but serum magnesium level was elevated after treatment (
<.05). There were no significant differences between PTH changes and sex, age, scores of
Tc thyroid scan, scores of
I WBS, Tumor (T) stage, and Node (N) stage.
RAI therapy following surgery did not significantly affect parathyroid function in DTC patients.
= American Thyroid Association;
= differentiated thyroid carcinoma;
= free triiodothyronine;
= free thyroxine;
= iodine-131;
= parathyroid hormone;
= radioiodine;
= Technetium-99m;
= thyroglobulin;
= Tumor Node Metastasis;
= thyroid-stimulating hormone;
= whole-body scan.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>31968192</pmid><doi>10.4158/EP-2019-0398</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Endocrine practice, 2020-04, Vol.26 (4), p.416-422 |
| issn | 1530-891X 1934-2403 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2344224061 |
| source | MEDLINE; ProQuest Central UK/Ireland; Alma/SFX Local Collection |
| subjects | Cancer therapies Combined Modality Therapy Humans Immunoassay Iodine Iodine Radioisotopes Males Parathyroid Glands Patients Phosphorus Software Studies Thyroglobulin Thyroid cancer Thyroid Neoplasms - radiotherapy Thyroid Neoplasms - surgery Thyroidectomy Tomography, X-Ray Computed |
| title | EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER |
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