Luminescent Silver-Purine Double Helicate: Synthesis, Self-Assembly and Antibacterial Action
The synthesis, self‐assembly and antibacterial activity of a luminescent silver–purine double helicate is reported. The structure of the newly synthesized silver‐supported helicate [C36H24N16O4Cl5Ag1] was unambiguously characterized by single‐crystal X‐ray crystallography. It exhibited a bright blui...
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| Veröffentlicht in: | ChemPlusChem (Weinheim, Germany) Germany), 2016-12, Vol.81 (12), p.1266-1271 |
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| creator | Venkatesh, V. Kumaran, M. D. Bala Saravanan, R. Kamal Kalaichelvan, P. T. Verma, Sandeep |
| description | The synthesis, self‐assembly and antibacterial activity of a luminescent silver–purine double helicate is reported. The structure of the newly synthesized silver‐supported helicate [C36H24N16O4Cl5Ag1] was unambiguously characterized by single‐crystal X‐ray crystallography. It exhibited a bright bluish‐green emission (λmax=460 nm), when excited with 380 nm light. Microscopic investigations showed that the complex has a propensity to self‐assemble into nanospheres. The antibacterial activity of this silver‐containing helicate was studied against both Gram‐positive and Gram‐negative bacteria. MIC (minimal inhibitory concentration) values showed that the complex is very active against Gram‐negative bacteria. Further internalization of the silver complex into E. coli bacteria was mapped with the help of microscopic techniques. These results are significant as silver was recently found to enhance antibiotic action against Gram‐negative bacteria, raising hope in countering severe bacterial infections.
A silver lining: A luminescent silver–purine complex was synthesized which self‐assembles to form a double helicate with antibacterial properties. Cell internalization of this complex was followed by fluorescence spectroscopy and it was found to have more pronounced inhibitory activity towards the Gram‐negative bacteria. |
| doi_str_mv | 10.1002/cplu.201600293 |
| format | Article |
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A silver lining: A luminescent silver–purine complex was synthesized which self‐assembles to form a double helicate with antibacterial properties. Cell internalization of this complex was followed by fluorescence spectroscopy and it was found to have more pronounced inhibitory activity towards the Gram‐negative bacteria.</description><identifier>ISSN: 2192-6506</identifier><identifier>EISSN: 2192-6506</identifier><identifier>DOI: 10.1002/cplu.201600293</identifier><identifier>PMID: 31964074</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Antibiotics ; Bacteria ; Biofilms ; Chemistry ; Crystal lattices ; Deoxyribonucleic acid ; DNA ; E coli ; Enzymes ; Gram-negative bacteria ; Ligands ; luminescence ; metalloantibiotics ; Nanoparticles ; self-assembly ; Silver</subject><ispartof>ChemPlusChem (Weinheim, Germany), 2016-12, Vol.81 (12), p.1266-1271</ispartof><rights>2016 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright Blackwell Publishing Ltd. Dec 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4113-374fbca26118a5d81177a8465f3db7e48f4ff8204fbe2af4ba58de5b1b765bbe3</citedby><cites>FETCH-LOGICAL-c4113-374fbca26118a5d81177a8465f3db7e48f4ff8204fbe2af4ba58de5b1b765bbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcplu.201600293$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcplu.201600293$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31964074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Venkatesh, V.</creatorcontrib><creatorcontrib>Kumaran, M. D. Bala</creatorcontrib><creatorcontrib>Saravanan, R. Kamal</creatorcontrib><creatorcontrib>Kalaichelvan, P. T.</creatorcontrib><creatorcontrib>Verma, Sandeep</creatorcontrib><title>Luminescent Silver-Purine Double Helicate: Synthesis, Self-Assembly and Antibacterial Action</title><title>ChemPlusChem (Weinheim, Germany)</title><addtitle>ChemPlusChem</addtitle><description>The synthesis, self‐assembly and antibacterial activity of a luminescent silver–purine double helicate is reported. The structure of the newly synthesized silver‐supported helicate [C36H24N16O4Cl5Ag1] was unambiguously characterized by single‐crystal X‐ray crystallography. It exhibited a bright bluish‐green emission (λmax=460 nm), when excited with 380 nm light. Microscopic investigations showed that the complex has a propensity to self‐assemble into nanospheres. The antibacterial activity of this silver‐containing helicate was studied against both Gram‐positive and Gram‐negative bacteria. MIC (minimal inhibitory concentration) values showed that the complex is very active against Gram‐negative bacteria. Further internalization of the silver complex into E. coli bacteria was mapped with the help of microscopic techniques. These results are significant as silver was recently found to enhance antibiotic action against Gram‐negative bacteria, raising hope in countering severe bacterial infections.
A silver lining: A luminescent silver–purine complex was synthesized which self‐assembles to form a double helicate with antibacterial properties. Cell internalization of this complex was followed by fluorescence spectroscopy and it was found to have more pronounced inhibitory activity towards the Gram‐negative bacteria.</description><subject>Antibiotics</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Chemistry</subject><subject>Crystal lattices</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>E coli</subject><subject>Enzymes</subject><subject>Gram-negative bacteria</subject><subject>Ligands</subject><subject>luminescence</subject><subject>metalloantibiotics</subject><subject>Nanoparticles</subject><subject>self-assembly</subject><subject>Silver</subject><issn>2192-6506</issn><issn>2192-6506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqFkM9v0zAcxS0EYlPZlSOKxIUDKf7thFtVWIdWQaUycUGy7ORr4eEknZ0w-t_jqqOauPAu9tf6vKevH0IvCZ4TjOm7ZhemOcVE5qFmT9A5JTUtpcDy6aP7GbpI6RZnSSyoYs_RGSO15Fjxc_R9PXW-h9RAPxZbH35BLDdTzE_Fh2GyAYorCL4xI7wvtvt-_AHJp7fFFoIrFylBZ8O-MH1bLPrRW9OMEL0JxaIZ_dC_QM-cCQkuHs4Zurn8-HV5Va6_rD4tF-uy4YSwkinubGOoJKQyoq0IUcpUXArHWquAV447V1GcKaDGcWtE1YKwxCoprAU2Q2-Oubs43E2QRt35_KMQTA_DlDRlnAksJBUZff0PejtMsc_baVJJomp20AzNj1QTh5QiOL2LvjNxrwnWh-r1oXp9qj4bXj3ETraD9oT_LToD9RG49wH2_4nTy8365nF4efT6NMLvk9fEn1oqpoT-9nmlr-mKbq4PXvYHNNqeqA</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Venkatesh, V.</creator><creator>Kumaran, M. 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D. Bala</au><au>Saravanan, R. Kamal</au><au>Kalaichelvan, P. T.</au><au>Verma, Sandeep</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Luminescent Silver-Purine Double Helicate: Synthesis, Self-Assembly and Antibacterial Action</atitle><jtitle>ChemPlusChem (Weinheim, Germany)</jtitle><addtitle>ChemPlusChem</addtitle><date>2016-12</date><risdate>2016</risdate><volume>81</volume><issue>12</issue><spage>1266</spage><epage>1271</epage><pages>1266-1271</pages><issn>2192-6506</issn><eissn>2192-6506</eissn><abstract>The synthesis, self‐assembly and antibacterial activity of a luminescent silver–purine double helicate is reported. The structure of the newly synthesized silver‐supported helicate [C36H24N16O4Cl5Ag1] was unambiguously characterized by single‐crystal X‐ray crystallography. It exhibited a bright bluish‐green emission (λmax=460 nm), when excited with 380 nm light. Microscopic investigations showed that the complex has a propensity to self‐assemble into nanospheres. The antibacterial activity of this silver‐containing helicate was studied against both Gram‐positive and Gram‐negative bacteria. MIC (minimal inhibitory concentration) values showed that the complex is very active against Gram‐negative bacteria. Further internalization of the silver complex into E. coli bacteria was mapped with the help of microscopic techniques. These results are significant as silver was recently found to enhance antibiotic action against Gram‐negative bacteria, raising hope in countering severe bacterial infections.
A silver lining: A luminescent silver–purine complex was synthesized which self‐assembles to form a double helicate with antibacterial properties. Cell internalization of this complex was followed by fluorescence spectroscopy and it was found to have more pronounced inhibitory activity towards the Gram‐negative bacteria.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>31964074</pmid><doi>10.1002/cplu.201600293</doi><tpages>6</tpages></addata></record> |
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| subjects | Antibiotics Bacteria Biofilms Chemistry Crystal lattices Deoxyribonucleic acid DNA E coli Enzymes Gram-negative bacteria Ligands luminescence metalloantibiotics Nanoparticles self-assembly Silver |
| title | Luminescent Silver-Purine Double Helicate: Synthesis, Self-Assembly and Antibacterial Action |
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