A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) are poorly understood, posing a major obstacle for the identification of patients potentially amenable for immune-checkpoint blockade or other novel strategies. Here, we explore the association of chemokine expres...

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Veröffentlicht in:	Clinical cancer research 2020-04, Vol.26 (8), p.1997-2010
Hauptverfasser:	Romero, Joan M, Grünwald, Barbara, Jang, Gun-Ho, Bavi, Prashant P, Jhaveri, Aaditeya, Masoomian, Mehdi, Fischer, Sandra E, Zhang, Amy, Denroche, Robert E, Lungu, Ilinca M, De Luca, Angela, Bartlett, John M S, Xu, Jing, Li, Niandong, Dhaliwal, Sharon, Liang, Sheng-Ben, Chadwick, Dianne, Vyas, Foram, Bronsert, Peter, Khokha, Rama, McGaha, Tracy L, Notta, Faiyaz, Ohashi, Pamela S, Done, Susan J, O'Kane, Grainne M, Wilson, Julie M, Knox, Jennifer J, Connor, Ashton, Wang, Yifan, Zogopoulos, George, Gallinger, Steven
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology CD8-Positive T-Lymphocytes - immunology Chemokine CCL4 - genetics Chemokine CCL4 - immunology Chemokine CCL5 - genetics Chemokine CCL5 - immunology Chemokine CXCL10 - genetics Chemokine CXCL10 - immunology Chemokine CXCL9 - genetics Chemokine CXCL9 - immunology Cohort Studies Computational Biology - methods Databases, Genetic - statistics & numerical data Humans Immune Checkpoint Proteins - genetics Immunotherapy - methods Liver Neoplasms - genetics Liver Neoplasms - immunology Liver Neoplasms - secondary Mutation Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology RNA-Seq - methods
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