Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report
Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalass...
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creator | Manara, Renzo Caiazza, Martina Di Concilio, Rosanna Ciancio, Angela De Michele, Elisa Maietta, Caterina Capalbo, Daniela Russo, Camilla Roberti, Domenico Casale, Maddalena Elefante, Andrea Esposito, Fabrizio Ponticorvo, Sara Russo, Andrea Gerardo Canna, Antonietta Cirillo, Mario Perrotta, Silverio Tartaglione, Immacolata |
description | Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management. |
doi_str_mv | 10.1186/s13023-020-1302-3 |
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Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.</description><identifier>ISSN: 1750-1172</identifier><identifier>EISSN: 1750-1172</identifier><identifier>DOI: 10.1186/s13023-020-1302-3</identifier><identifier>PMID: 31959195</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Aneurysm ; Aneurysms ; Angiography ; Beta-thalassemia ; Brain damage ; Diagnostic imaging ; Enlargement ; Genetics & Heredity ; Hemorrhage ; Life Sciences & Biomedicine ; Literature reviews ; Magnetic resonance angiography ; Medical imaging ; Medical research ; Medicine, Research & Experimental ; Patient compliance ; Patients ; Rare diseases ; Research & Experimental Medicine ; Scanners ; Science & Technology ; Statistics ; Stroke ; Subarachnoid hemorrhage ; Thalassemia</subject><ispartof>Orphanet journal of rare diseases, 2020-01, Vol.15 (1), p.21-21, Article 21</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s). 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>3</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000521311000001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c594t-87b837839c2d4c503519da89e08a632ef991175f68fcd7dad65fbf2a06a728433</citedby><cites>FETCH-LOGICAL-c594t-87b837839c2d4c503519da89e08a632ef991175f68fcd7dad65fbf2a06a728433</cites><orcidid>0000-0001-6149-6845 ; 0000-0002-2256-7281 ; 0000-0002-5130-3971</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971974/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971974/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2115,27929,27930,28253,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31959195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manara, Renzo</creatorcontrib><creatorcontrib>Caiazza, Martina</creatorcontrib><creatorcontrib>Di Concilio, Rosanna</creatorcontrib><creatorcontrib>Ciancio, Angela</creatorcontrib><creatorcontrib>De Michele, Elisa</creatorcontrib><creatorcontrib>Maietta, Caterina</creatorcontrib><creatorcontrib>Capalbo, Daniela</creatorcontrib><creatorcontrib>Russo, Camilla</creatorcontrib><creatorcontrib>Roberti, Domenico</creatorcontrib><creatorcontrib>Casale, Maddalena</creatorcontrib><creatorcontrib>Elefante, Andrea</creatorcontrib><creatorcontrib>Esposito, Fabrizio</creatorcontrib><creatorcontrib>Ponticorvo, Sara</creatorcontrib><creatorcontrib>Russo, Andrea Gerardo</creatorcontrib><creatorcontrib>Canna, Antonietta</creatorcontrib><creatorcontrib>Cirillo, Mario</creatorcontrib><creatorcontrib>Perrotta, Silverio</creatorcontrib><creatorcontrib>Tartaglione, Immacolata</creatorcontrib><title>Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report</title><title>Orphanet journal of rare diseases</title><addtitle>ORPHANET J RARE DIS</addtitle><addtitle>Orphanet J Rare Dis</addtitle><description>Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.</description><subject>Aneurysm</subject><subject>Aneurysms</subject><subject>Angiography</subject><subject>Beta-thalassemia</subject><subject>Brain damage</subject><subject>Diagnostic imaging</subject><subject>Enlargement</subject><subject>Genetics & Heredity</subject><subject>Hemorrhage</subject><subject>Life Sciences & Biomedicine</subject><subject>Literature reviews</subject><subject>Magnetic resonance angiography</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine, Research & Experimental</subject><subject>Patient compliance</subject><subject>Patients</subject><subject>Rare diseases</subject><subject>Research & Experimental Medicine</subject><subject>Scanners</subject><subject>Science & Technology</subject><subject>Statistics</subject><subject>Stroke</subject><subject>Subarachnoid 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Renzo</creator><creator>Caiazza, Martina</creator><creator>Di Concilio, Rosanna</creator><creator>Ciancio, Angela</creator><creator>De Michele, Elisa</creator><creator>Maietta, Caterina</creator><creator>Capalbo, Daniela</creator><creator>Russo, Camilla</creator><creator>Roberti, Domenico</creator><creator>Casale, Maddalena</creator><creator>Elefante, Andrea</creator><creator>Esposito, Fabrizio</creator><creator>Ponticorvo, Sara</creator><creator>Russo, Andrea Gerardo</creator><creator>Canna, Antonietta</creator><creator>Cirillo, Mario</creator><creator>Perrotta, Silverio</creator><creator>Tartaglione, Immacolata</creator><general>Springer Nature</general><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6149-6845</orcidid><orcidid>https://orcid.org/0000-0002-2256-7281</orcidid><orcidid>https://orcid.org/0000-0002-5130-3971</orcidid></search><sort><creationdate>20200120</creationdate><title>Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report</title><author>Manara, Renzo ; Caiazza, Martina ; Di Concilio, Rosanna ; Ciancio, Angela ; De Michele, Elisa ; Maietta, Caterina ; Capalbo, Daniela ; Russo, Camilla ; Roberti, Domenico ; Casale, Maddalena ; Elefante, Andrea ; Esposito, Fabrizio ; Ponticorvo, Sara ; Russo, Andrea Gerardo ; Canna, Antonietta ; Cirillo, Mario ; Perrotta, Silverio ; Tartaglione, Immacolata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-87b837839c2d4c503519da89e08a632ef991175f68fcd7dad65fbf2a06a728433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aneurysm</topic><topic>Aneurysms</topic><topic>Angiography</topic><topic>Beta-thalassemia</topic><topic>Brain damage</topic><topic>Diagnostic imaging</topic><topic>Enlargement</topic><topic>Genetics & Heredity</topic><topic>Hemorrhage</topic><topic>Life Sciences & Biomedicine</topic><topic>Literature reviews</topic><topic>Magnetic resonance angiography</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine, Research & Experimental</topic><topic>Patient compliance</topic><topic>Patients</topic><topic>Rare diseases</topic><topic>Research & Experimental Medicine</topic><topic>Scanners</topic><topic>Science & Technology</topic><topic>Statistics</topic><topic>Stroke</topic><topic>Subarachnoid hemorrhage</topic><topic>Thalassemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manara, Renzo</creatorcontrib><creatorcontrib>Caiazza, Martina</creatorcontrib><creatorcontrib>Di Concilio, Rosanna</creatorcontrib><creatorcontrib>Ciancio, Angela</creatorcontrib><creatorcontrib>De Michele, Elisa</creatorcontrib><creatorcontrib>Maietta, Caterina</creatorcontrib><creatorcontrib>Capalbo, Daniela</creatorcontrib><creatorcontrib>Russo, Camilla</creatorcontrib><creatorcontrib>Roberti, 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Gerardo</au><au>Canna, Antonietta</au><au>Cirillo, Mario</au><au>Perrotta, Silverio</au><au>Tartaglione, Immacolata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report</atitle><jtitle>Orphanet journal of rare diseases</jtitle><stitle>ORPHANET J RARE DIS</stitle><addtitle>Orphanet J Rare Dis</addtitle><date>2020-01-20</date><risdate>2020</risdate><volume>15</volume><issue>1</issue><spage>21</spage><epage>21</epage><pages>21-21</pages><artnum>21</artnum><issn>1750-1172</issn><eissn>1750-1172</eissn><abstract>Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>31959195</pmid><doi>10.1186/s13023-020-1302-3</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6149-6845</orcidid><orcidid>https://orcid.org/0000-0002-2256-7281</orcidid><orcidid>https://orcid.org/0000-0002-5130-3971</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aneurysm Aneurysms Angiography Beta-thalassemia Brain damage Diagnostic imaging Enlargement Genetics & Heredity Hemorrhage Life Sciences & Biomedicine Literature reviews Magnetic resonance angiography Medical imaging Medical research Medicine, Research & Experimental Patient compliance Patients Rare diseases Research & Experimental Medicine Scanners Science & Technology Statistics Stroke Subarachnoid hemorrhage Thalassemia |
title | Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report |
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