Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report

Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalass...

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Veröffentlicht in:Orphanet journal of rare diseases 2020-01, Vol.15 (1), p.21-21, Article 21
Hauptverfasser: Manara, Renzo, Caiazza, Martina, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Maietta, Caterina, Capalbo, Daniela, Russo, Camilla, Roberti, Domenico, Casale, Maddalena, Elefante, Andrea, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea Gerardo, Canna, Antonietta, Cirillo, Mario, Perrotta, Silverio, Tartaglione, Immacolata
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container_issue 1
container_start_page 21
container_title Orphanet journal of rare diseases
container_volume 15
creator Manara, Renzo
Caiazza, Martina
Di Concilio, Rosanna
Ciancio, Angela
De Michele, Elisa
Maietta, Caterina
Capalbo, Daniela
Russo, Camilla
Roberti, Domenico
Casale, Maddalena
Elefante, Andrea
Esposito, Fabrizio
Ponticorvo, Sara
Russo, Andrea Gerardo
Canna, Antonietta
Cirillo, Mario
Perrotta, Silverio
Tartaglione, Immacolata
description Background No information is currently available regarding the natural history of asymptomatic intracranial aneurysms in beta-thalassemia, raising several concerns about their proper management. Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.
doi_str_mv 10.1186/s13023-020-1302-3
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Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.</description><identifier>ISSN: 1750-1172</identifier><identifier>EISSN: 1750-1172</identifier><identifier>DOI: 10.1186/s13023-020-1302-3</identifier><identifier>PMID: 31959195</identifier><language>eng</language><publisher>LONDON: Springer Nature</publisher><subject>Aneurysm ; Aneurysms ; Angiography ; Beta-thalassemia ; Brain damage ; Diagnostic imaging ; Enlargement ; Genetics &amp; Heredity ; Hemorrhage ; Life Sciences &amp; Biomedicine ; Literature reviews ; Magnetic resonance angiography ; Medical imaging ; Medical research ; Medicine, Research &amp; Experimental ; Patient compliance ; Patients ; Rare diseases ; Research &amp; Experimental Medicine ; Scanners ; Science &amp; Technology ; Statistics ; Stroke ; Subarachnoid hemorrhage ; Thalassemia</subject><ispartof>Orphanet journal of rare diseases, 2020-01, Vol.15 (1), p.21-21, Article 21</ispartof><rights>COPYRIGHT 2020 BioMed Central Ltd.</rights><rights>2020. 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Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. 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Methods We performed a prospective longitudinal three-year-long MR-angiography study on nine beta-thalassemia patients (mean-age 40.3 +/- 7.5, six females, 8 transfusion dependent) harboring ten asymptomatic intracranial aneurysms. In addition, we analyzed the clinical files of all adult beta-thalassemia patients (160 patients including those followed with MR-angiography, 121 transfusion dependent) referring to our Centers between 2014 and 2019 searching for history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Results At the end of the three-year-long follow-up, no patient showed any change in the size and shape of the aneurysms, none presented new intracranial aneurysms or artery stenoses, none showed new brain vascular-like parenchymal lesions or enlargement of the preexisting ones. Besides, in our database of all adult beta-thalassemia patients, no one had history of subarachnoid hemorrhage or history of symptomatic intracranial aneurysms. Conclusions Incidental asymptomatic intracranial aneurysms do not seem to be associated, in beta-thalassemia, with an increased risk of complications (enlargement or rupture) at least in the short term period, helping to optimize human and economic resources and patient compliance during their complex long-lasting management.</abstract><cop>LONDON</cop><pub>Springer Nature</pub><pmid>31959195</pmid><doi>10.1186/s13023-020-1302-3</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-6149-6845</orcidid><orcidid>https://orcid.org/0000-0002-2256-7281</orcidid><orcidid>https://orcid.org/0000-0002-5130-3971</orcidid><oa>free_for_read</oa></addata></record>
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subjects Aneurysm
Aneurysms
Angiography
Beta-thalassemia
Brain damage
Diagnostic imaging
Enlargement
Genetics & Heredity
Hemorrhage
Life Sciences & Biomedicine
Literature reviews
Magnetic resonance angiography
Medical imaging
Medical research
Medicine, Research & Experimental
Patient compliance
Patients
Rare diseases
Research & Experimental Medicine
Scanners
Science & Technology
Statistics
Stroke
Subarachnoid hemorrhage
Thalassemia
title Asymptomatic intracranial aneurysms in beta-thalassemia: a three-year follow-up report
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