Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction
Background: Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activatio...
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| Veröffentlicht in: | European heart journal. Acute cardiovascular care 2020-09, Vol.9 (6), p.557-566 |
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| creator | Frydland, Martin Møller, Jacob E Lindholm, Matias G Hansen, Rikke Wiberg, Sebastian Lerche Helgestad, Ole Kristian Thomsen, Jakob H Goetze, Jens P Engstrøm, Thomas Frikke-Schmidt, Ruth Ravn, Hanne B Holmvang, Lene Jensen, Lisette O Kjaergaard, Jesper Hassager, Christian |
| description | Background:
Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown.
Methods and results:
In 93% of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10%) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9%). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19–3.13) even when adjusted for the recently developed Observatoire Régional Breton sur l’Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Régional Breton sur l’Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p |
| doi_str_mv | 10.1177/2048872619896063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2343039138</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2048872619896063</sage_id><sourcerecordid>2343039138</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-18ec97b978ab52a071eaec77a759dcc9990b824b0ea8eb7c764f67f3ec5f9c553</originalsourceid><addsrcrecordid>eNp1UD1PwzAUtBCIVqU7E_LIErDjJLZHqPiSkBgoc-Q4L63bJA52UtR_j0tLByTe8k737k56h9AlJTeUcn4bk0QIHmdUCpmRjJ2g8Y6KBGfJ6RHH2QhNvV-RMJxkiWDnaMSozCiV6Rht741tlFuD87hzUBrdmw1gW-Fa9YC1cqWxC2iNxn5p9RqXsIHadg20PTYt7lRvAvT4y_RL7Affge6hxO_zCGrYhKttcbO1P0GqDpZKOb1jL9BZpWoP08OeoI_Hh_nsOXp9e3qZ3b1GmnHZR1SAlryQXKgijRXhFBRozhVPZam1lJIUIk4KAkpAwTXPkirjFQOdVlKnKZug631u5-znAL7PG-M11LVqwQ4-j1nCCJOUiSAle6l21nsHVd45E9rZ5pTku87zv50Hy9UhfSgaKI-G34aDINoLvFpAvrKDa8O3_wd-A0GLi_s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2343039138</pqid></control><display><type>article</type><title>Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>SAGE Complete</source><creator>Frydland, Martin ; Møller, Jacob E ; Lindholm, Matias G ; Hansen, Rikke ; Wiberg, Sebastian ; Lerche Helgestad, Ole Kristian ; Thomsen, Jakob H ; Goetze, Jens P ; Engstrøm, Thomas ; Frikke-Schmidt, Ruth ; Ravn, Hanne B ; Holmvang, Lene ; Jensen, Lisette O ; Kjaergaard, Jesper ; Hassager, Christian</creator><creatorcontrib>Frydland, Martin ; Møller, Jacob E ; Lindholm, Matias G ; Hansen, Rikke ; Wiberg, Sebastian ; Lerche Helgestad, Ole Kristian ; Thomsen, Jakob H ; Goetze, Jens P ; Engstrøm, Thomas ; Frikke-Schmidt, Ruth ; Ravn, Hanne B ; Holmvang, Lene ; Jensen, Lisette O ; Kjaergaard, Jesper ; Hassager, Christian</creatorcontrib><description>Background:
Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown.
Methods and results:
In 93% of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10%) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9%). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19–3.13) even when adjusted for the recently developed Observatoire Régional Breton sur l’Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Régional Breton sur l’Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p<0.05; mid-regional pro-adrenomedullin: 0.88, p=0.006).
Conclusions:
Pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 admission plasma concentration were associated with late cardiogenic shock development in patients admitted with suspected ST-elevation myocardial infarction. Pro-atrial natriuretic peptide, mid-regional pro-adrenomedullin and copeptin had independent predictive value for late cardiogenic shock development.</description><identifier>ISSN: 2048-8726</identifier><identifier>EISSN: 2048-8734</identifier><identifier>DOI: 10.1177/2048872619896063</identifier><identifier>PMID: 31961195</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Aged ; Atrial Natriuretic Factor - blood ; Biomarkers - blood ; Female ; Follow-Up Studies ; Humans ; Male ; Natriuretic Peptide, Brain - blood ; Prognosis ; Retrospective Studies ; ROC Curve ; Shock, Cardiogenic - blood ; Shock, Cardiogenic - etiology ; ST Elevation Myocardial Infarction - blood ; ST Elevation Myocardial Infarction - complications</subject><ispartof>European heart journal. Acute cardiovascular care, 2020-09, Vol.9 (6), p.557-566</ispartof><rights>The European Society of Cardiology 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-18ec97b978ab52a071eaec77a759dcc9990b824b0ea8eb7c764f67f3ec5f9c553</citedby><cites>FETCH-LOGICAL-c379t-18ec97b978ab52a071eaec77a759dcc9990b824b0ea8eb7c764f67f3ec5f9c553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2048872619896063$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2048872619896063$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31961195$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frydland, Martin</creatorcontrib><creatorcontrib>Møller, Jacob E</creatorcontrib><creatorcontrib>Lindholm, Matias G</creatorcontrib><creatorcontrib>Hansen, Rikke</creatorcontrib><creatorcontrib>Wiberg, Sebastian</creatorcontrib><creatorcontrib>Lerche Helgestad, Ole Kristian</creatorcontrib><creatorcontrib>Thomsen, Jakob H</creatorcontrib><creatorcontrib>Goetze, Jens P</creatorcontrib><creatorcontrib>Engstrøm, Thomas</creatorcontrib><creatorcontrib>Frikke-Schmidt, Ruth</creatorcontrib><creatorcontrib>Ravn, Hanne B</creatorcontrib><creatorcontrib>Holmvang, Lene</creatorcontrib><creatorcontrib>Jensen, Lisette O</creatorcontrib><creatorcontrib>Kjaergaard, Jesper</creatorcontrib><creatorcontrib>Hassager, Christian</creatorcontrib><title>Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction</title><title>European heart journal. Acute cardiovascular care</title><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><description>Background:
Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown.
Methods and results:
In 93% of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10%) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9%). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19–3.13) even when adjusted for the recently developed Observatoire Régional Breton sur l’Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Régional Breton sur l’Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p<0.05; mid-regional pro-adrenomedullin: 0.88, p=0.006).
Conclusions:
Pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 admission plasma concentration were associated with late cardiogenic shock development in patients admitted with suspected ST-elevation myocardial infarction. Pro-atrial natriuretic peptide, mid-regional pro-adrenomedullin and copeptin had independent predictive value for late cardiogenic shock development.</description><subject>Aged</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Biomarkers - blood</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Shock, Cardiogenic - blood</subject><subject>Shock, Cardiogenic - etiology</subject><subject>ST Elevation Myocardial Infarction - blood</subject><subject>ST Elevation Myocardial Infarction - complications</subject><issn>2048-8726</issn><issn>2048-8734</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UD1PwzAUtBCIVqU7E_LIErDjJLZHqPiSkBgoc-Q4L63bJA52UtR_j0tLByTe8k737k56h9AlJTeUcn4bk0QIHmdUCpmRjJ2g8Y6KBGfJ6RHH2QhNvV-RMJxkiWDnaMSozCiV6Rht741tlFuD87hzUBrdmw1gW-Fa9YC1cqWxC2iNxn5p9RqXsIHadg20PTYt7lRvAvT4y_RL7Affge6hxO_zCGrYhKttcbO1P0GqDpZKOb1jL9BZpWoP08OeoI_Hh_nsOXp9e3qZ3b1GmnHZR1SAlryQXKgijRXhFBRozhVPZam1lJIUIk4KAkpAwTXPkirjFQOdVlKnKZug631u5-znAL7PG-M11LVqwQ4-j1nCCJOUiSAle6l21nsHVd45E9rZ5pTku87zv50Hy9UhfSgaKI-G34aDINoLvFpAvrKDa8O3_wd-A0GLi_s</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Frydland, Martin</creator><creator>Møller, Jacob E</creator><creator>Lindholm, Matias G</creator><creator>Hansen, Rikke</creator><creator>Wiberg, Sebastian</creator><creator>Lerche Helgestad, Ole Kristian</creator><creator>Thomsen, Jakob H</creator><creator>Goetze, Jens P</creator><creator>Engstrøm, Thomas</creator><creator>Frikke-Schmidt, Ruth</creator><creator>Ravn, Hanne B</creator><creator>Holmvang, Lene</creator><creator>Jensen, Lisette O</creator><creator>Kjaergaard, Jesper</creator><creator>Hassager, Christian</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction</title><author>Frydland, Martin ; Møller, Jacob E ; Lindholm, Matias G ; Hansen, Rikke ; Wiberg, Sebastian ; Lerche Helgestad, Ole Kristian ; Thomsen, Jakob H ; Goetze, Jens P ; Engstrøm, Thomas ; Frikke-Schmidt, Ruth ; Ravn, Hanne B ; Holmvang, Lene ; Jensen, Lisette O ; Kjaergaard, Jesper ; Hassager, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-18ec97b978ab52a071eaec77a759dcc9990b824b0ea8eb7c764f67f3ec5f9c553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Biomarkers - blood</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Shock, Cardiogenic - blood</topic><topic>Shock, Cardiogenic - etiology</topic><topic>ST Elevation Myocardial Infarction - blood</topic><topic>ST Elevation Myocardial Infarction - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frydland, Martin</creatorcontrib><creatorcontrib>Møller, Jacob E</creatorcontrib><creatorcontrib>Lindholm, Matias G</creatorcontrib><creatorcontrib>Hansen, Rikke</creatorcontrib><creatorcontrib>Wiberg, Sebastian</creatorcontrib><creatorcontrib>Lerche Helgestad, Ole Kristian</creatorcontrib><creatorcontrib>Thomsen, Jakob H</creatorcontrib><creatorcontrib>Goetze, Jens P</creatorcontrib><creatorcontrib>Engstrøm, Thomas</creatorcontrib><creatorcontrib>Frikke-Schmidt, Ruth</creatorcontrib><creatorcontrib>Ravn, Hanne B</creatorcontrib><creatorcontrib>Holmvang, Lene</creatorcontrib><creatorcontrib>Jensen, Lisette O</creatorcontrib><creatorcontrib>Kjaergaard, Jesper</creatorcontrib><creatorcontrib>Hassager, Christian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal. Acute cardiovascular care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frydland, Martin</au><au>Møller, Jacob E</au><au>Lindholm, Matias G</au><au>Hansen, Rikke</au><au>Wiberg, Sebastian</au><au>Lerche Helgestad, Ole Kristian</au><au>Thomsen, Jakob H</au><au>Goetze, Jens P</au><au>Engstrøm, Thomas</au><au>Frikke-Schmidt, Ruth</au><au>Ravn, Hanne B</au><au>Holmvang, Lene</au><au>Jensen, Lisette O</au><au>Kjaergaard, Jesper</au><au>Hassager, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction</atitle><jtitle>European heart journal. Acute cardiovascular care</jtitle><addtitle>Eur Heart J Acute Cardiovasc Care</addtitle><date>2020-09</date><risdate>2020</risdate><volume>9</volume><issue>6</issue><spage>557</spage><epage>566</epage><pages>557-566</pages><issn>2048-8726</issn><eissn>2048-8734</eissn><abstract>Background:
Cardiogenic shock complicating ST-elevation myocardial infarction is characterised by progressive left ventricular dysfunction causing inflammation and neurohormonal activation. Often, cardiogenic shock develops after hospital admission. Whether inflammation and a neurohormonal activation precede development of clinical cardiogenic shock is unknown.
Methods and results:
In 93% of 2247 consecutive patients with suspected ST-elevation myocardial infarction admitted at two tertiary heart centres, admission plasma levels of pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 were measured on hospital admission. Patients were stratified according to no cardiogenic shock development and cardiogenic shock developed before (early cardiogenic shock) or after (late cardiogenic shock) leaving the catheterization laboratory. In total, 225 (10%) patients developed cardiogenic shock, amongst these patients late cardiogenic shock occurred in 64 (2.9%). All four biomarkers were independently associated with the development of late cardiogenic shock (odds ratio per two-fold increase in risk: 1.19–3.13) even when adjusted for the recently developed Observatoire Régional Breton sur l’Infarctus risk score for prediction of late cardiogenic shock development. Furthermore, pro-atrial natriuretic peptide, copeptin and mid-regional pro-adrenomedullin, but not stimulation-2, added significant predictive information, when added to the Observatoire Régional Breton sur l’Infarctus risk score (area under the receiver-operating characteristic curve, pro-atrial natriuretic peptide: 0.87, p=0.0008; copeptin: 0.86, p<0.05; mid-regional pro-adrenomedullin: 0.88, p=0.006).
Conclusions:
Pro-atrial natriuretic peptide, copeptin, mid-regional pro-adrenomedullin and stimulation-2 admission plasma concentration were associated with late cardiogenic shock development in patients admitted with suspected ST-elevation myocardial infarction. Pro-atrial natriuretic peptide, mid-regional pro-adrenomedullin and copeptin had independent predictive value for late cardiogenic shock development.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31961195</pmid><doi>10.1177/2048872619896063</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European heart journal. Acute cardiovascular care, 2020-09, Vol.9 (6), p.557-566 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; SAGE Complete |
| subjects | Aged Atrial Natriuretic Factor - blood Biomarkers - blood Female Follow-Up Studies Humans Male Natriuretic Peptide, Brain - blood Prognosis Retrospective Studies ROC Curve Shock, Cardiogenic - blood Shock, Cardiogenic - etiology ST Elevation Myocardial Infarction - blood ST Elevation Myocardial Infarction - complications |
| title | Biomarkers predictive of late cardiogenic shock development in patients with suspected ST-elevation myocardial infarction |
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