Sex-related electrocardiographic differences in patients with different types of atrial fibrillation: Results from the SWISS-AF study
Sex-related electrocardiographic differences are a well-known phenomenon, but not their expression in patients with atrial fibrillation (AF). In this study we aim to assess the presence of significant sex-related differences in ECG features, with particular attention to P-wave parameters, of a large...
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| Veröffentlicht in: | International journal of cardiology 2020-05, Vol.307, p.63-70 |
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| creator | Laureanti, Rita Conte, Giulio Corino, Valentina D.A. Osswald, Stefan Conen, David Roten, Laurent Rodondi, Nicolas Ammann, Peter Meyer-Zuern, Christine S. Bonati, Leo Mainardi, Luca T. Auricchio, Angelo |
| description | Sex-related electrocardiographic differences are a well-known phenomenon, but not their expression in patients with atrial fibrillation (AF). In this study we aim to assess the presence of significant sex-related differences in ECG features, with particular attention to P-wave parameters, of a large cohort of patients affected by different types of AF.
A 5-min resting 16-lead ECG was evaluated for 1119 AF patients in sinus rhythm. The durations of the main ECG waves and intervals were measured for both atrial and ventricular activity. Moreover, the beat-to-beat P-wave variability was computed for lead II and for the first principal component (PC1) computed across the 16 leads. The percentage of variance explained by PC1 was computed.
Males compared to females showed significantly longer RR interval (1.02 ± 0.16 s vs 0.97 ± 0.15 s, p |
| doi_str_mv | 10.1016/j.ijcard.2019.12.053 |
| format | Article |
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A 5-min resting 16-lead ECG was evaluated for 1119 AF patients in sinus rhythm. The durations of the main ECG waves and intervals were measured for both atrial and ventricular activity. Moreover, the beat-to-beat P-wave variability was computed for lead II and for the first principal component (PC1) computed across the 16 leads. The percentage of variance explained by PC1 was computed.
Males compared to females showed significantly longer RR interval (1.02 ± 0.16 s vs 0.97 ± 0.15 s, p < .001), PQ interval (191 ± 34 ms vs 183 ± 35 ms, p = .008), QRS duration (105 ± 17 ms vs 98 ± 13 ms, p = .021), significantly lower percentage of variance explained by PC1 and P-wave variability. Males with paroxysmal AF compared to females with paroxysmal AF had significantly longer RR interval (1.01 ± 0.17 s vs 0.96 ± 0.14 s, p < .001), shorter QTc (388 ± 27 ms vs 402 ± 27 ms, p < .001), lower P-wave variability in PC1. Males with persistent AF compared to females with persistent AF had significantly shorter QTc interval (396 ± 30 ms vs 407 ± 26 ms, p = .019), longer PQ interval (194 ± 35 ms vs 182 ± 30 ms, p = .037), higher V1 terminal force (2.1 ± 1.2 mV*ms vs 1.8 ± 1 mV*ms, p = .007), lower percentage of variance explained by PC1.
AF patients present with several sex-related ECG differences. Consequently, sex should be taken into account when developing ECG algorithms identifying patients at risk for AF progression.
•ECG parameters show significant differences between males and females with AF in SR.•Male AF patients had longer RR, PQ and QRS intervals than females during SR.•Male AF patients had significantly lower P-wave variability than females during SR.•Male/females differences were found also in paroxysmal and persistent AF groups.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2019.12.053</identifier><identifier>PMID: 31959406</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Algorithms ; Atrial fibrillation ; Atrial Fibrillation - diagnosis ; Electrocardiogram ; Electrocardiography ; Female ; Heart Atria ; Humans ; Male ; P-wave ; Sex ; Sex Characteristics ; Swiss-AF</subject><ispartof>International journal of cardiology, 2020-05, Vol.307, p.63-70</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-93fce7eb314133ae6468dfe2369c914a36e02e56ac3749322b84c55fd4a7043c3</citedby><cites>FETCH-LOGICAL-c408t-93fce7eb314133ae6468dfe2369c914a36e02e56ac3749322b84c55fd4a7043c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0167527319346856$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31959406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laureanti, Rita</creatorcontrib><creatorcontrib>Conte, Giulio</creatorcontrib><creatorcontrib>Corino, Valentina D.A.</creatorcontrib><creatorcontrib>Osswald, Stefan</creatorcontrib><creatorcontrib>Conen, David</creatorcontrib><creatorcontrib>Roten, Laurent</creatorcontrib><creatorcontrib>Rodondi, Nicolas</creatorcontrib><creatorcontrib>Ammann, Peter</creatorcontrib><creatorcontrib>Meyer-Zuern, Christine S.</creatorcontrib><creatorcontrib>Bonati, Leo</creatorcontrib><creatorcontrib>Mainardi, Luca T.</creatorcontrib><creatorcontrib>Auricchio, Angelo</creatorcontrib><creatorcontrib>Swiss-AF study investigators</creatorcontrib><title>Sex-related electrocardiographic differences in patients with different types of atrial fibrillation: Results from the SWISS-AF study</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Sex-related electrocardiographic differences are a well-known phenomenon, but not their expression in patients with atrial fibrillation (AF). In this study we aim to assess the presence of significant sex-related differences in ECG features, with particular attention to P-wave parameters, of a large cohort of patients affected by different types of AF.
A 5-min resting 16-lead ECG was evaluated for 1119 AF patients in sinus rhythm. The durations of the main ECG waves and intervals were measured for both atrial and ventricular activity. Moreover, the beat-to-beat P-wave variability was computed for lead II and for the first principal component (PC1) computed across the 16 leads. The percentage of variance explained by PC1 was computed.
Males compared to females showed significantly longer RR interval (1.02 ± 0.16 s vs 0.97 ± 0.15 s, p < .001), PQ interval (191 ± 34 ms vs 183 ± 35 ms, p = .008), QRS duration (105 ± 17 ms vs 98 ± 13 ms, p = .021), significantly lower percentage of variance explained by PC1 and P-wave variability. Males with paroxysmal AF compared to females with paroxysmal AF had significantly longer RR interval (1.01 ± 0.17 s vs 0.96 ± 0.14 s, p < .001), shorter QTc (388 ± 27 ms vs 402 ± 27 ms, p < .001), lower P-wave variability in PC1. Males with persistent AF compared to females with persistent AF had significantly shorter QTc interval (396 ± 30 ms vs 407 ± 26 ms, p = .019), longer PQ interval (194 ± 35 ms vs 182 ± 30 ms, p = .037), higher V1 terminal force (2.1 ± 1.2 mV*ms vs 1.8 ± 1 mV*ms, p = .007), lower percentage of variance explained by PC1.
AF patients present with several sex-related ECG differences. Consequently, sex should be taken into account when developing ECG algorithms identifying patients at risk for AF progression.
•ECG parameters show significant differences between males and females with AF in SR.•Male AF patients had longer RR, PQ and QRS intervals than females during SR.•Male AF patients had significantly lower P-wave variability than females during SR.•Male/females differences were found also in paroxysmal and persistent AF groups.</description><subject>Algorithms</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Electrocardiogram</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Atria</subject><subject>Humans</subject><subject>Male</subject><subject>P-wave</subject><subject>Sex</subject><subject>Sex Characteristics</subject><subject>Swiss-AF</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhDRDykk2C_xLHLJCqqoVKlZA6RSwtj33NeJSJg-1A5wF4bzya0iWru_B3zr0-B6G3lLSU0P7Drg07a5JrGaGqpawlHX-GVnSQoqGyE8_RqmKy6ZjkZ-hVzjtCiFBqeInOOFWdEqRfoT9reGgSjKaAwzCCLSkeXUP8kcy8DRa74D0kmCxkHCY8mxJgKhn_DmX79FhwOcwViB6bkoIZsQ-bFMbqG-L0Ed9BXsYq8inucdkCXn-_Wa-bi2ucy-IOr9ELb8YMbx7nOfp2fXV_-aW5_fr55vLitrGCDKVR3FuQsOFUUM4N9KIfnAfGe2UVFYb3QBh0vbFcCsUZ2wzCdp13wkgiuOXn6P3Jd07x5wK56H3IFuqZE8Qla8YFJ1xKPlRUnFCbYs4JvJ5T2Jt00JToYwF6p08F6GMBmjJdC6iyd48bls0e3JPoX-IV-HQCoP7zV4Cksw3HdF1INX3tYvj_hr8rdpqx</recordid><startdate>20200515</startdate><enddate>20200515</enddate><creator>Laureanti, Rita</creator><creator>Conte, Giulio</creator><creator>Corino, Valentina D.A.</creator><creator>Osswald, Stefan</creator><creator>Conen, David</creator><creator>Roten, Laurent</creator><creator>Rodondi, Nicolas</creator><creator>Ammann, Peter</creator><creator>Meyer-Zuern, Christine S.</creator><creator>Bonati, Leo</creator><creator>Mainardi, Luca T.</creator><creator>Auricchio, Angelo</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200515</creationdate><title>Sex-related electrocardiographic differences in patients with different types of atrial fibrillation: Results from the SWISS-AF study</title><author>Laureanti, Rita ; Conte, Giulio ; Corino, Valentina D.A. ; Osswald, Stefan ; Conen, David ; Roten, Laurent ; Rodondi, Nicolas ; Ammann, Peter ; Meyer-Zuern, Christine S. ; Bonati, Leo ; Mainardi, Luca T. ; Auricchio, Angelo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-93fce7eb314133ae6468dfe2369c914a36e02e56ac3749322b84c55fd4a7043c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algorithms</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Electrocardiogram</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Atria</topic><topic>Humans</topic><topic>Male</topic><topic>P-wave</topic><topic>Sex</topic><topic>Sex Characteristics</topic><topic>Swiss-AF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laureanti, Rita</creatorcontrib><creatorcontrib>Conte, Giulio</creatorcontrib><creatorcontrib>Corino, Valentina D.A.</creatorcontrib><creatorcontrib>Osswald, Stefan</creatorcontrib><creatorcontrib>Conen, David</creatorcontrib><creatorcontrib>Roten, Laurent</creatorcontrib><creatorcontrib>Rodondi, Nicolas</creatorcontrib><creatorcontrib>Ammann, Peter</creatorcontrib><creatorcontrib>Meyer-Zuern, Christine S.</creatorcontrib><creatorcontrib>Bonati, Leo</creatorcontrib><creatorcontrib>Mainardi, Luca T.</creatorcontrib><creatorcontrib>Auricchio, Angelo</creatorcontrib><creatorcontrib>Swiss-AF study investigators</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laureanti, Rita</au><au>Conte, Giulio</au><au>Corino, Valentina D.A.</au><au>Osswald, Stefan</au><au>Conen, David</au><au>Roten, Laurent</au><au>Rodondi, Nicolas</au><au>Ammann, Peter</au><au>Meyer-Zuern, Christine S.</au><au>Bonati, Leo</au><au>Mainardi, Luca T.</au><au>Auricchio, Angelo</au><aucorp>Swiss-AF study investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-related electrocardiographic differences in patients with different types of atrial fibrillation: Results from the SWISS-AF study</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2020-05-15</date><risdate>2020</risdate><volume>307</volume><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Sex-related electrocardiographic differences are a well-known phenomenon, but not their expression in patients with atrial fibrillation (AF). In this study we aim to assess the presence of significant sex-related differences in ECG features, with particular attention to P-wave parameters, of a large cohort of patients affected by different types of AF.
A 5-min resting 16-lead ECG was evaluated for 1119 AF patients in sinus rhythm. The durations of the main ECG waves and intervals were measured for both atrial and ventricular activity. Moreover, the beat-to-beat P-wave variability was computed for lead II and for the first principal component (PC1) computed across the 16 leads. The percentage of variance explained by PC1 was computed.
Males compared to females showed significantly longer RR interval (1.02 ± 0.16 s vs 0.97 ± 0.15 s, p < .001), PQ interval (191 ± 34 ms vs 183 ± 35 ms, p = .008), QRS duration (105 ± 17 ms vs 98 ± 13 ms, p = .021), significantly lower percentage of variance explained by PC1 and P-wave variability. Males with paroxysmal AF compared to females with paroxysmal AF had significantly longer RR interval (1.01 ± 0.17 s vs 0.96 ± 0.14 s, p < .001), shorter QTc (388 ± 27 ms vs 402 ± 27 ms, p < .001), lower P-wave variability in PC1. Males with persistent AF compared to females with persistent AF had significantly shorter QTc interval (396 ± 30 ms vs 407 ± 26 ms, p = .019), longer PQ interval (194 ± 35 ms vs 182 ± 30 ms, p = .037), higher V1 terminal force (2.1 ± 1.2 mV*ms vs 1.8 ± 1 mV*ms, p = .007), lower percentage of variance explained by PC1.
AF patients present with several sex-related ECG differences. Consequently, sex should be taken into account when developing ECG algorithms identifying patients at risk for AF progression.
•ECG parameters show significant differences between males and females with AF in SR.•Male AF patients had longer RR, PQ and QRS intervals than females during SR.•Male AF patients had significantly lower P-wave variability than females during SR.•Male/females differences were found also in paroxysmal and persistent AF groups.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>31959406</pmid><doi>10.1016/j.ijcard.2019.12.053</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Algorithms Atrial fibrillation Atrial Fibrillation - diagnosis Electrocardiogram Electrocardiography Female Heart Atria Humans Male P-wave Sex Sex Characteristics Swiss-AF |
| title | Sex-related electrocardiographic differences in patients with different types of atrial fibrillation: Results from the SWISS-AF study |
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