High‐level heterologous production of propionate in engineered Escherichia coli

A propanologenic (i.e., 1‐propanol‐producing) bacterium Escherichia coli strain was previously derived by activating the genomic sleeping beauty mutase (Sbm) operon. The activated Sbm pathway branches out of the tricarboxylic acid (TCA) cycle at the succinyl‐CoA node to form propionyl‐CoA and its de...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-05, Vol.117 (5), p.1304-1315
Hauptverfasser:	Miscevic, Dragan, Mao, Ju‐Yi, Moo‐Young, Murray, Chou, Chih‐Hsiung Perry
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobic conditions Anaerobic conditions Biosynthesis Carbon Coliforms Cultivation Deregulation E coli Escherichia coli Fluctuations Flux glycerol Metabolic flux Metabolism Metabolites Mutants Mutation Propanol propionate Propionic acid propionyl‐CoA sleeping beauty mutase TCA cycle Tricarboxylic acid cycle
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