Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats
In our previous study, we found that the methanolic extract of Sanoshashinto (三黄瀉心湯) (SHXXTM) exhibited significant vasorelaxant effects in vitro and antihypertensive effects in vivo, and baicalin and berberine were the main antihypertensive constituents in SHXXTM. We also speculated that the baical...
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| Veröffentlicht in: | Journal of natural medicines 2020-03, Vol.74 (2), p.482-486 |
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| creator | Wu, Jianbo Nakashima, Souichi Nakamura, Seikou Matsuda, Hisashi |
| description | In our previous study, we found that the methanolic extract of Sanoshashinto (三黄瀉心湯) (SHXXTM) exhibited significant vasorelaxant effects in vitro and antihypertensive effects in vivo, and baicalin and berberine were the main antihypertensive constituents in SHXXTM. We also speculated that the baicalin–berberine (BB) combination produced vasorelaxant effects by activating the NO/cGMP pathway, and the BK
Ca
channel and the DAG/PKC/CPI-17 pathway were involved. In this study, we examined the vasorelaxant effects using helical strips of rat aorta pretreated with different activators or inhibitors. The results suggested that the K
ATP
channel and the voltage-dependent Ca
2+
channel (VDCC) were also involved in the vasorelaxant effects. Furthermore, we found that SHXXTM and the BB combination reduced left ventricular hypertrophy and altered gut microbiota. Together, the results indicated that Sanoshashinto might have comprehensive effects on ameliorating hypertension. |
| doi_str_mv | 10.1007/s11418-020-01387-9 |
| format | Article |
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Ca
channel and the DAG/PKC/CPI-17 pathway were involved. In this study, we examined the vasorelaxant effects using helical strips of rat aorta pretreated with different activators or inhibitors. The results suggested that the K
ATP
channel and the voltage-dependent Ca
2+
channel (VDCC) were also involved in the vasorelaxant effects. Furthermore, we found that SHXXTM and the BB combination reduced left ventricular hypertrophy and altered gut microbiota. Together, the results indicated that Sanoshashinto might have comprehensive effects on ameliorating hypertension.</description><identifier>ISSN: 1340-3443</identifier><identifier>EISSN: 1861-0293</identifier><identifier>DOI: 10.1007/s11418-020-01387-9</identifier><identifier>PMID: 31956959</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Animals ; Antihypertensives ; Aorta ; Baicalin ; Berberine ; Biomedical and Life Sciences ; Biomedicine ; Calcium ; Calcium channels (voltage-gated) ; Complementary & Alternative Medicine ; Cyclic GMP ; Disease Models, Animal ; Gastrointestinal Microbiome - drug effects ; Heart ; Hypertension ; Hypertension - drug therapy ; Hypertrophy ; Hypertrophy, Left Ventricular - drug therapy ; Intestinal microflora ; Male ; Medicinal Chemistry ; Methanol - pharmacology ; Methanol - therapeutic use ; Microbiota ; Organic chemicals ; Pharmacology/Toxicology ; Pharmacy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Sciences ; Protein kinase C ; Rats ; Rats, Sprague-Dawley ; Rodents ; Vasodilator Agents - pharmacology ; Vasodilator Agents - therapeutic use ; Ventricle</subject><ispartof>Journal of natural medicines, 2020-03, Vol.74 (2), p.482-486</ispartof><rights>The Japanese Society of Pharmacognosy 2020</rights><rights>2020© The Japanese Society of Pharmacognosy 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-bfb188ddd73a71c689ee4d8c64b31f9d4a395f00ca0861226525a545183073793</citedby><cites>FETCH-LOGICAL-c492t-bfb188ddd73a71c689ee4d8c64b31f9d4a395f00ca0861226525a545183073793</cites><orcidid>0000-0003-4217-065X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11418-020-01387-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11418-020-01387-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31956959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jianbo</creatorcontrib><creatorcontrib>Nakashima, Souichi</creatorcontrib><creatorcontrib>Nakamura, Seikou</creatorcontrib><creatorcontrib>Matsuda, Hisashi</creatorcontrib><title>Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats</title><title>Journal of natural medicines</title><addtitle>J Nat Med</addtitle><addtitle>J Nat Med</addtitle><description>In our previous study, we found that the methanolic extract of Sanoshashinto (三黄瀉心湯) (SHXXTM) exhibited significant vasorelaxant effects in vitro and antihypertensive effects in vivo, and baicalin and berberine were the main antihypertensive constituents in SHXXTM. We also speculated that the baicalin–berberine (BB) combination produced vasorelaxant effects by activating the NO/cGMP pathway, and the BK
Ca
channel and the DAG/PKC/CPI-17 pathway were involved. In this study, we examined the vasorelaxant effects using helical strips of rat aorta pretreated with different activators or inhibitors. The results suggested that the K
ATP
channel and the voltage-dependent Ca
2+
channel (VDCC) were also involved in the vasorelaxant effects. Furthermore, we found that SHXXTM and the BB combination reduced left ventricular hypertrophy and altered gut microbiota. Together, the results indicated that Sanoshashinto might have comprehensive effects on ameliorating hypertension.</description><subject>Animals</subject><subject>Antihypertensives</subject><subject>Aorta</subject><subject>Baicalin</subject><subject>Berberine</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Calcium</subject><subject>Calcium channels (voltage-gated)</subject><subject>Complementary & Alternative Medicine</subject><subject>Cyclic GMP</subject><subject>Disease Models, Animal</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Heart</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Hypertrophy</subject><subject>Hypertrophy, Left Ventricular - drug therapy</subject><subject>Intestinal microflora</subject><subject>Male</subject><subject>Medicinal Chemistry</subject><subject>Methanol - pharmacology</subject><subject>Methanol - therapeutic use</subject><subject>Microbiota</subject><subject>Organic chemicals</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Sciences</subject><subject>Protein kinase C</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Vasodilator Agents - therapeutic use</subject><subject>Ventricle</subject><issn>1340-3443</issn><issn>1861-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9PwyAYxonRuDn9Ah4MiRcvVSjQwtGY-SdZ4kE9E9rC1qWDCtRk315mpyYevACBH8_7vO8DwDlG1xih8iZgTDHPUI4yhAkvM3EAppgXOF0JcpjOhKKMUEom4CSENUI0JwQfgwnBghWCiSmwc2N0HQN0Br4o68JKhVVro4POwk6bCD-0jb6th055uNr22kfv-tUWKtvA5RDhpq29q1oXFWwtDL2zUVnthtBt97y2of3Q0KsYTsGRUV3QZ_t9Bt7u5693j9ni-eHp7naR1VTkMatMhTlvmqYkqsR1wYXWtOF1QSuCjWioIoIZhGqFUrt5XrCcKUYZ5gSVpBRkBq5G3d6790GHKDdtqHXXjdZkTtIoWFEWPKGXf9C1G7xN7hJVsEThtM5APlKp2RC8NrL37Ub5rcRI7tKQYxoypSG_0pA7Fxd76aHa6Obny_f4E0BGIKQnu9T-t_Y_sp-4vpZJ</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Wu, Jianbo</creator><creator>Nakashima, Souichi</creator><creator>Nakamura, Seikou</creator><creator>Matsuda, Hisashi</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4217-065X</orcidid></search><sort><creationdate>20200301</creationdate><title>Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats</title><author>Wu, Jianbo ; Nakashima, Souichi ; Nakamura, Seikou ; Matsuda, Hisashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-bfb188ddd73a71c689ee4d8c64b31f9d4a395f00ca0861226525a545183073793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antihypertensives</topic><topic>Aorta</topic><topic>Baicalin</topic><topic>Berberine</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Calcium</topic><topic>Calcium channels (voltage-gated)</topic><topic>Complementary & Alternative Medicine</topic><topic>Cyclic GMP</topic><topic>Disease Models, Animal</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Heart</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Hypertrophy</topic><topic>Hypertrophy, Left Ventricular - drug therapy</topic><topic>Intestinal microflora</topic><topic>Male</topic><topic>Medicinal Chemistry</topic><topic>Methanol - pharmacology</topic><topic>Methanol - therapeutic use</topic><topic>Microbiota</topic><topic>Organic chemicals</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Sciences</topic><topic>Protein kinase C</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Vasodilator Agents - therapeutic use</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jianbo</creatorcontrib><creatorcontrib>Nakashima, Souichi</creatorcontrib><creatorcontrib>Nakamura, Seikou</creatorcontrib><creatorcontrib>Matsuda, Hisashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jianbo</au><au>Nakashima, Souichi</au><au>Nakamura, Seikou</au><au>Matsuda, Hisashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats</atitle><jtitle>Journal of natural medicines</jtitle><stitle>J Nat Med</stitle><addtitle>J Nat Med</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>74</volume><issue>2</issue><spage>482</spage><epage>486</epage><pages>482-486</pages><issn>1340-3443</issn><eissn>1861-0293</eissn><abstract>In our previous study, we found that the methanolic extract of Sanoshashinto (三黄瀉心湯) (SHXXTM) exhibited significant vasorelaxant effects in vitro and antihypertensive effects in vivo, and baicalin and berberine were the main antihypertensive constituents in SHXXTM. We also speculated that the baicalin–berberine (BB) combination produced vasorelaxant effects by activating the NO/cGMP pathway, and the BK
Ca
channel and the DAG/PKC/CPI-17 pathway were involved. In this study, we examined the vasorelaxant effects using helical strips of rat aorta pretreated with different activators or inhibitors. The results suggested that the K
ATP
channel and the voltage-dependent Ca
2+
channel (VDCC) were also involved in the vasorelaxant effects. Furthermore, we found that SHXXTM and the BB combination reduced left ventricular hypertrophy and altered gut microbiota. Together, the results indicated that Sanoshashinto might have comprehensive effects on ameliorating hypertension.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>31956959</pmid><doi>10.1007/s11418-020-01387-9</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4217-065X</orcidid></addata></record> |
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| subjects | Animals Antihypertensives Aorta Baicalin Berberine Biomedical and Life Sciences Biomedicine Calcium Calcium channels (voltage-gated) Complementary & Alternative Medicine Cyclic GMP Disease Models, Animal Gastrointestinal Microbiome - drug effects Heart Hypertension Hypertension - drug therapy Hypertrophy Hypertrophy, Left Ventricular - drug therapy Intestinal microflora Male Medicinal Chemistry Methanol - pharmacology Methanol - therapeutic use Microbiota Organic chemicals Pharmacology/Toxicology Pharmacy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Sciences Protein kinase C Rats Rats, Sprague-Dawley Rodents Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Ventricle |
| title | Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats |
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