sgp120 and the contact system in hereditary angioedema: A diagnostic tool in HAE with normal C1 inhibitor

•sgp120 has been identified as ITIH4, can be cleaved by kallikrein, and can be used to study contact system activation.•sgp120 fragmentation and spontaneous contact system activation is present in the plasma of a majority of HAE-C1inh patients.•sgp120 fragmentation and contact system activation occu...

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Veröffentlicht in:	Molecular immunology 2020-03, Vol.119, p.27-34
Hauptverfasser:	Larrauri, Blas, Hester, C. Garren, Jiang, Haixiang, Miletic, Vojislav D., Malbran, Alejandro, Bork, Konrad, Kaplan, Allen, Frank, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioedemas, Hereditary - blood Angioedemas, Hereditary - diagnosis Angioedemas, Hereditary - genetics Biomarker Biomarkers - blood Blood Coagulation Factors - metabolism Chromatography - methods Complement Activation Complement C1 Inhibitor Protein - metabolism Contact system of activation Diagnosis Factor XII - genetics Hereditary angioedema with C1 inhibitor deficiency Hereditary angioedema with normal C1 inhibitor Humans Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) Kallikreins - metabolism Kaolin - metabolism Peptide Fragments - blood Plasminogen - genetics Plastics Proteinase Inhibitory Proteins, Secretory - blood Proteolysis serum glycoprotein 120 (sgp120)
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