Cleavage, Downregulation, and Aggregation of Serum Amyloid A

Various diseases cause overexpression of the serum amyloid A (SAA) protein, which in some cases, but not in all cases, leads to amyloidosis as a secondary disease. Response to the overexpression involves dissociation of the SAA hexamer and subsequent cleavage of the released monomers, most commonly...

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Veröffentlicht in:	The journal of physical chemistry. B 2020-02, Vol.124 (6), p.1009-1019
Hauptverfasser:	Wang, Wenhua, Khatua, Prabir, Hansmann, Ulrich H. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Down-Regulation Models, Molecular Protein Aggregates Protein Conformation Serum Amyloid A Protein - chemistry Serum Amyloid A Protein - metabolism
Online-Zugang:	Volltext
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