Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity

Recent studies on sphingolipids suggest that acid sphingomyelinase (ASM), which plays a central role in the pathogenesis of major depression, is emerging to be a novel target for developing antidepressants. Herein we first described the design, synthesis, and biological evaluation of hydroxamic acid...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-02, Vol.63 (3), p.961-974
Hauptverfasser:	Yang, Kan, Yu, Jinying, Nong, Keyi, Wang, Youzhi, Niu, Ao, Chen, Wenlu, Dong, Jibin, Wang, Jinxin
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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