Quantitative muscle MRI study of patients with sporadic inclusion body myositis
Background Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed. Methods Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal‐to‐distal and side asymmetries, and the...
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| Veröffentlicht in: | Muscle & nerve 2020-04, Vol.61 (4), p.496-503 |
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| creator | Ansari, Behnaz Salort‐Campana, Emmanuelle Ogier, Augustin Le Troter PhD, Arnaud De Sainte Marie, Benjamin Guye, Maxime Delmont, Emilien Grapperon, Aude‐Marie Verschueren, Annie Bendahan, David Attarian, Shahram |
| description | Background
Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed.
Methods
Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal‐to‐distal and side asymmetries, and the correlations with clinical and functional parameters were investigated.
Results
All the patients had fat‐infiltrated muscles, and thighs were more severely affected than LL. A proximal‐to‐distal gradient of fat infiltration was mainly observed for adductors, quadriceps, sartorius, and medial gastrocnemius muscles. A strong negative correlation was observed between the whole muscle fat fraction in the thighs and LL and the Inclusion Body Myositis Functional Rating Scale and Medical Research Council scores for the lower limbs.
Conclusions
Fat infiltration in individual muscles of sIBM patients is heterogeneous in terms of proximal‐to‐distal gradient and severity was correlated with clinical scores. These results should be considered for both natural history investigation and clinical trials. |
| doi_str_mv | 10.1002/mus.26813 |
| format | Article |
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Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed.
Methods
Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal‐to‐distal and side asymmetries, and the correlations with clinical and functional parameters were investigated.
Results
All the patients had fat‐infiltrated muscles, and thighs were more severely affected than LL. A proximal‐to‐distal gradient of fat infiltration was mainly observed for adductors, quadriceps, sartorius, and medial gastrocnemius muscles. A strong negative correlation was observed between the whole muscle fat fraction in the thighs and LL and the Inclusion Body Myositis Functional Rating Scale and Medical Research Council scores for the lower limbs.
Conclusions
Fat infiltration in individual muscles of sIBM patients is heterogeneous in terms of proximal‐to‐distal gradient and severity was correlated with clinical scores. These results should be considered for both natural history investigation and clinical trials.</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.26813</identifier><identifier>PMID: 31953869</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aged ; Clinical trials ; Correlation analysis ; fat infiltration ; Female ; Humans ; IBM ; Infiltration ; Inflammatory diseases ; Life Sciences ; Lower Extremity - diagnostic imaging ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Medical research ; Middle Aged ; MRI ; Muscle, Skeletal - diagnostic imaging ; Muscles ; Musculoskeletal diseases ; Myositis ; Myositis, Inclusion Body - diagnostic imaging ; Patients ; Quadriceps muscle ; quantitative ; Thigh - diagnostic imaging</subject><ispartof>Muscle & nerve, 2020-04, Vol.61 (4), p.496-503</ispartof><rights>2020 Wiley Periodicals, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3873-1b95c14d4ac19e9f67c1a762c849051ebc2eb0e1fe8aa1f56c4b95868794b2763</citedby><cites>FETCH-LOGICAL-c3873-1b95c14d4ac19e9f67c1a762c849051ebc2eb0e1fe8aa1f56c4b95868794b2763</cites><orcidid>0000-0001-9178-9964 ; 0000-0002-7211-4694 ; 0000-0002-7897-9672 ; 0000-0002-1502-0958 ; 0000-0002-5591-2774</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.26813$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.26813$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31953869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02444963$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Ansari, Behnaz</creatorcontrib><creatorcontrib>Salort‐Campana, Emmanuelle</creatorcontrib><creatorcontrib>Ogier, Augustin</creatorcontrib><creatorcontrib>Le Troter PhD, Arnaud</creatorcontrib><creatorcontrib>De Sainte Marie, Benjamin</creatorcontrib><creatorcontrib>Guye, Maxime</creatorcontrib><creatorcontrib>Delmont, Emilien</creatorcontrib><creatorcontrib>Grapperon, Aude‐Marie</creatorcontrib><creatorcontrib>Verschueren, Annie</creatorcontrib><creatorcontrib>Bendahan, David</creatorcontrib><creatorcontrib>Attarian, Shahram</creatorcontrib><title>Quantitative muscle MRI study of patients with sporadic inclusion body myositis</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Background
Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed.
Methods
Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal‐to‐distal and side asymmetries, and the correlations with clinical and functional parameters were investigated.
Results
All the patients had fat‐infiltrated muscles, and thighs were more severely affected than LL. A proximal‐to‐distal gradient of fat infiltration was mainly observed for adductors, quadriceps, sartorius, and medial gastrocnemius muscles. A strong negative correlation was observed between the whole muscle fat fraction in the thighs and LL and the Inclusion Body Myositis Functional Rating Scale and Medical Research Council scores for the lower limbs.
Conclusions
Fat infiltration in individual muscles of sIBM patients is heterogeneous in terms of proximal‐to‐distal gradient and severity was correlated with clinical scores. These results should be considered for both natural history investigation and clinical trials.</description><subject>Aged</subject><subject>Clinical trials</subject><subject>Correlation analysis</subject><subject>fat infiltration</subject><subject>Female</subject><subject>Humans</subject><subject>IBM</subject><subject>Infiltration</subject><subject>Inflammatory diseases</subject><subject>Life Sciences</subject><subject>Lower Extremity - diagnostic imaging</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Muscle, Skeletal - diagnostic imaging</subject><subject>Muscles</subject><subject>Musculoskeletal diseases</subject><subject>Myositis</subject><subject>Myositis, Inclusion Body - diagnostic imaging</subject><subject>Patients</subject><subject>Quadriceps muscle</subject><subject>quantitative</subject><subject>Thigh - diagnostic imaging</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1LwzAUhoMobk4v_AMS8EYvqjlNmiaXMvyCyfBj4F1Is5RF2mY2rbJ_b8Z0guDVgZwnT97wInQM5AIISS_rPlykXADdQUMgMk9YJsUuGhJgIuFUvg7QQQhvhBAQPN9HAwoyo4LLIZo-9rrpXKc792FxFJnK4oenexy6fr7CvsTLuLJNF_Cn6xY4LH2r585g15iqD843uPARrFc-uM6FQ7RX6irYo-85QrOb65fxXTKZ3t6PryaJoSKnCRQyM8DmTBuQVpY8N6BznhrBJMnAFia1BbFQWqE1lBk3LN4QXOSSFWnO6Qidb7wLXall62rdrpTXTt1dTdT6jKSMMcnpB0T2bMMuW__e29Cp2gVjq0o31vdBpZQBB8EgjejpH_TN920TfxKpnMcAhGS_j5vWh9DacpsAiFo3ouq1dt1IZE--jX1R2_mW_KkgApcb4NNVdvW_ST3MnjfKL8RjlBo</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Ansari, Behnaz</creator><creator>Salort‐Campana, Emmanuelle</creator><creator>Ogier, Augustin</creator><creator>Le Troter PhD, Arnaud</creator><creator>De Sainte Marie, Benjamin</creator><creator>Guye, Maxime</creator><creator>Delmont, Emilien</creator><creator>Grapperon, Aude‐Marie</creator><creator>Verschueren, Annie</creator><creator>Bendahan, David</creator><creator>Attarian, Shahram</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TS</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-9178-9964</orcidid><orcidid>https://orcid.org/0000-0002-7211-4694</orcidid><orcidid>https://orcid.org/0000-0002-7897-9672</orcidid><orcidid>https://orcid.org/0000-0002-1502-0958</orcidid><orcidid>https://orcid.org/0000-0002-5591-2774</orcidid></search><sort><creationdate>202004</creationdate><title>Quantitative muscle MRI study of patients with sporadic inclusion body myositis</title><author>Ansari, Behnaz ; Salort‐Campana, Emmanuelle ; Ogier, Augustin ; Le Troter PhD, Arnaud ; De Sainte Marie, Benjamin ; Guye, Maxime ; Delmont, Emilien ; Grapperon, Aude‐Marie ; Verschueren, Annie ; Bendahan, David ; Attarian, Shahram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3873-1b95c14d4ac19e9f67c1a762c849051ebc2eb0e1fe8aa1f56c4b95868794b2763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Clinical trials</topic><topic>Correlation analysis</topic><topic>fat infiltration</topic><topic>Female</topic><topic>Humans</topic><topic>IBM</topic><topic>Infiltration</topic><topic>Inflammatory diseases</topic><topic>Life Sciences</topic><topic>Lower Extremity - diagnostic imaging</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Muscle, Skeletal - diagnostic imaging</topic><topic>Muscles</topic><topic>Musculoskeletal diseases</topic><topic>Myositis</topic><topic>Myositis, Inclusion Body - diagnostic imaging</topic><topic>Patients</topic><topic>Quadriceps muscle</topic><topic>quantitative</topic><topic>Thigh - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ansari, Behnaz</creatorcontrib><creatorcontrib>Salort‐Campana, Emmanuelle</creatorcontrib><creatorcontrib>Ogier, Augustin</creatorcontrib><creatorcontrib>Le Troter PhD, Arnaud</creatorcontrib><creatorcontrib>De Sainte Marie, Benjamin</creatorcontrib><creatorcontrib>Guye, Maxime</creatorcontrib><creatorcontrib>Delmont, Emilien</creatorcontrib><creatorcontrib>Grapperon, Aude‐Marie</creatorcontrib><creatorcontrib>Verschueren, Annie</creatorcontrib><creatorcontrib>Bendahan, David</creatorcontrib><creatorcontrib>Attarian, Shahram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ansari, Behnaz</au><au>Salort‐Campana, Emmanuelle</au><au>Ogier, Augustin</au><au>Le Troter PhD, Arnaud</au><au>De Sainte Marie, Benjamin</au><au>Guye, Maxime</au><au>Delmont, Emilien</au><au>Grapperon, Aude‐Marie</au><au>Verschueren, Annie</au><au>Bendahan, David</au><au>Attarian, Shahram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative muscle MRI study of patients with sporadic inclusion body myositis</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2020-04</date><risdate>2020</risdate><volume>61</volume><issue>4</issue><spage>496</spage><epage>503</epage><pages>496-503</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><abstract>Background
Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed.
Methods
Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal‐to‐distal and side asymmetries, and the correlations with clinical and functional parameters were investigated.
Results
All the patients had fat‐infiltrated muscles, and thighs were more severely affected than LL. A proximal‐to‐distal gradient of fat infiltration was mainly observed for adductors, quadriceps, sartorius, and medial gastrocnemius muscles. A strong negative correlation was observed between the whole muscle fat fraction in the thighs and LL and the Inclusion Body Myositis Functional Rating Scale and Medical Research Council scores for the lower limbs.
Conclusions
Fat infiltration in individual muscles of sIBM patients is heterogeneous in terms of proximal‐to‐distal gradient and severity was correlated with clinical scores. These results should be considered for both natural history investigation and clinical trials.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31953869</pmid><doi>10.1002/mus.26813</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9178-9964</orcidid><orcidid>https://orcid.org/0000-0002-7211-4694</orcidid><orcidid>https://orcid.org/0000-0002-7897-9672</orcidid><orcidid>https://orcid.org/0000-0002-1502-0958</orcidid><orcidid>https://orcid.org/0000-0002-5591-2774</orcidid></addata></record> |
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| subjects | Aged Clinical trials Correlation analysis fat infiltration Female Humans IBM Infiltration Inflammatory diseases Life Sciences Lower Extremity - diagnostic imaging Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical research Middle Aged MRI Muscle, Skeletal - diagnostic imaging Muscles Musculoskeletal diseases Myositis Myositis, Inclusion Body - diagnostic imaging Patients Quadriceps muscle quantitative Thigh - diagnostic imaging |
| title | Quantitative muscle MRI study of patients with sporadic inclusion body myositis |
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