New approach to optimizing risk management of the sticking problem using scale-independent critical material attributes and the quantitative process parameter

[Display omitted] In pharmaceutical manufacturing of solid formulations, blending with a lubricant is a key process in preventing sticking during compression. Sticking not only results in tablets with a disfigured appearance but also brings about the interruption of continuous operations. The aim of...

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Veröffentlicht in:	International journal of pharmaceutics 2020-03, Vol.577, p.119032-119032, Article 119032
Hauptverfasser:	Ando, Hirotaka, Hara, Yuko, Sato, Kazunari, Dohi, Masafumi, Hakomori, Tadashi, Yonemochi, Etsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry, Pharmaceutical Compression Drug Compounding - methods Ethanol - chemistry Inverse gas chromatography Lubrication Risk Management Stearic Acids - chemistry Sticking Surface free energy
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