Analysis of Active Site Architecture and Reaction Product Linkage Chemistry Reveals a Conserved Cleavage Substrate for an Endo-alpha-mannanase within Diverse Yeast Mannans

Yeast α-mannan (YM) is a densely branched N-linked glycan that decorates the surface of yeast cell walls. Owing to the high degree of branching, cleavage of the backbone of YM appears to rely on the coupled action of side-chain-cleaving enzymes. Upon examining the genome sequences of bovine-adapted...

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Veröffentlicht in:	Journal of molecular biology 2020-02, Vol.432 (4), p.1083-1097
Hauptverfasser:	Jones, Darryl R., Xing, Xiaohui, Tingley, Jeffrey P., Klassen, Leeann, King, Marissa L., Alexander, Trevor W., Abbott, D. Wade
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteroides thetaiotaomicron Carbohydrate active enzyme glycosidic linkage analysis rumen bacteria x-ray crystallography
Online-Zugang:	Volltext
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