Proprotein convertase 7 (PCSK7) reduces apoA‐V levels

The locus of the human proprotein convertase subtilisin–kexin type‐7 (PC7) gene (PCSK7) is on chromosome 11q23.3 close to the gene cluster APOA5/APOA4/APOC3/APOA1, a region implicated in the regulation of lipoprotein metabolism. A GWAS reported the association of PCSK7 SNPs with plasma triglyceride ...

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Veröffentlicht in:	The FEBS journal 2020-08, Vol.287 (16), p.3565-3578
Hauptverfasser:	Ashraf, Yahya, Duval, Stéphanie, Sachan, Vatsal, Essalmani, Rachid, Susan‐Resiga, Delia, Roubtsova, Anna, Hamelin, Josée, Gerhardy, Stefan, Kirchhofer, Daniel, Tagliabracci, Vincent S., Prat, Annik, Kiss, Robert Scott, Seidah, Nabil G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Ammonium chloride Animals Apolipoprotein A Apolipoprotein A-V - blood Apolipoprotein A-V - metabolism apolipoprotein A‐V Cell Line, Tumor Chloroquine Chromosome 11 Chromosomes Degradation Endoplasmic reticulum Endoplasmic Reticulum - metabolism Hepatocytes - metabolism High fat diet Humans Kexin Kinases Linkage disequilibrium Lipase Lipid metabolism Lipoprotein lipase Liver Liver - metabolism Lysosomes Lysosomes - metabolism Mice, Inbred C57BL Mice, Knockout Minority & ethnic groups PC7 PCSK7 Phosphorylation Polymorphism, Single Nucleotide Proprotein convertases Single-nucleotide polymorphism Subtilisin Subtilisins - genetics Subtilisins - metabolism Triglycerides Triglycerides - blood Triglycerides - metabolism triglycerol Whole Exome Sequencing - methods
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