Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation

Extrahepatic cytochrome P450 1B1 (CYP1B1), which is highly expressed in various tumors, is an attractive and potential target for cancer prevention, therapy, and reversal of drug resistance. CYP1B1 inhibition is the current predominant therapeutic paradigm to treating CYP1B1-mediated malignancy, but...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-03, Vol.189, p.112028-112028, Article 112028
Hauptverfasser:	Zhou, Li, Chen, Wenming, Cao, Chenyang, Shi, Yonghui, Ye, Wenchong, Hu, Jiliang, Wang, LingLi, Zhou, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Click reaction CYP1B1 PROTACs Reversal of drug resistance α-Naphthoflavone-based conjugates
Online-Zugang:	Volltext
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