Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity

[Display omitted] The treatment for patients with chronic obstructive pulmonary disease (COPD) usually involves a combination of anti-inflammatory and bronchodilatory drugs. We recently found that mepenzolate bromide (1) and its derivative, 3-(2-hydroxy-2, 2-diphenylacetoxy)-1-(3-phenoxypropyl)-1-az...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2019-08, Vol.27 (15), p.3339-3346
Hauptverfasser:	Yamashita, Yasunobu, Tanaka, Ken-ichiro, Yamakawa, Naoki, Asano, Teita, Kanda, Yuki, Takafuji, Ayaka, Kawahara, Masahiro, Takenaga, Mitsuko, Fukunishi, Yoshifumi, Mizushima, Tohru
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical modification COPD Inflammatory Long-acting muscarinic antagonist Mepenzolate
Online-Zugang:	Volltext
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