Elevated TyG Index Predicts Progression of Coronary Artery Calcification
To investigate the triglyceride-glucose (TyG) index association with coronary artery calcification (CAC) progression in adult Koreans. Various cardiovascular risk factors and anthropometric profiles were assessed in 1,175 subjects who previously had a CAC evaluation at least twice by multidetector c...
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| Veröffentlicht in: | Diabetes care 2019-08, Vol.42 (8), p.1569-1573 |
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| creator | Park, Kahui Ahn, Chul Woo Lee, Sang Bae Kang, Shinae Nam, Ji Sun Lee, Byoung Kwon Kim, Jung Hye Park, Jong Suk |
| description | To investigate the triglyceride-glucose (TyG) index association with coronary artery calcification (CAC) progression in adult Koreans.
Various cardiovascular risk factors and anthropometric profiles were assessed in 1,175 subjects who previously had a CAC evaluation at least twice by multidetector computed tomography in a health care center. The TyG index was determined using ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACSs) of subjects with detectable CAC at baseline.
CAC progression was seen in 312 subjects (27%) during 4.2 years follow-up. On the basis of the TyG index, subjects were stratified into three groups. Follow-up CACS and incidence of CAC progression were markedly elevated with rising TyG index tertile. Logistic regression analysis adjusted for various risk factors revealed an odds ratio for CAC progression of 1.82 (95% CI 1.20-2.77;
≤ 0.01) when the highest and lowest TyG index tertiles were compared.
The TyG index is an independent predictor of CAC progression. |
| doi_str_mv | 10.2337/dc18-1920 |
| format | Article |
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Various cardiovascular risk factors and anthropometric profiles were assessed in 1,175 subjects who previously had a CAC evaluation at least twice by multidetector computed tomography in a health care center. The TyG index was determined using ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACSs) of subjects with detectable CAC at baseline.
CAC progression was seen in 312 subjects (27%) during 4.2 years follow-up. On the basis of the TyG index, subjects were stratified into three groups. Follow-up CACS and incidence of CAC progression were markedly elevated with rising TyG index tertile. Logistic regression analysis adjusted for various risk factors revealed an odds ratio for CAC progression of 1.82 (95% CI 1.20-2.77;
≤ 0.01) when the highest and lowest TyG index tertiles were compared.
The TyG index is an independent predictor of CAC progression.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc18-1920</identifier><identifier>PMID: 31182490</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adult ; Anthropometry ; Arteriosclerosis ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Calcification ; Calcification (ectopic) ; Calcium ; Cardiovascular diseases ; Computed tomography ; Coronary artery ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - pathology ; Coronary vessels ; Disease Progression ; Fasting ; Fasting - blood ; Female ; Glucose ; Health risk assessment ; Health risks ; Health Status Indicators ; Humans ; Incidence ; Indexing ; Laboratory testing ; Longitudinal Studies ; Male ; Middle Aged ; Prognosis ; Regression analysis ; Republic of Korea - epidemiology ; Research design ; Retrospective Studies ; Risk analysis ; Risk Factors ; Triglycerides ; Triglycerides - analysis ; Triglycerides - blood ; Vascular Calcification - blood ; Vascular Calcification - diagnosis ; Vascular Calcification - epidemiology ; Veins & arteries</subject><ispartof>Diabetes care, 2019-08, Vol.42 (8), p.1569-1573</ispartof><rights>2019 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Aug 1, 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-8f89ada21cbee2a830ffcce8a223ad277f9f52d723ad2faa1fe898023398d57f3</citedby><cites>FETCH-LOGICAL-c414t-8f89ada21cbee2a830ffcce8a223ad277f9f52d723ad2faa1fe898023398d57f3</cites><orcidid>0000-0002-9719-4774 ; 0000-0002-5385-1373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31182490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Kahui</creatorcontrib><creatorcontrib>Ahn, Chul Woo</creatorcontrib><creatorcontrib>Lee, Sang Bae</creatorcontrib><creatorcontrib>Kang, Shinae</creatorcontrib><creatorcontrib>Nam, Ji Sun</creatorcontrib><creatorcontrib>Lee, Byoung Kwon</creatorcontrib><creatorcontrib>Kim, Jung Hye</creatorcontrib><creatorcontrib>Park, Jong Suk</creatorcontrib><title>Elevated TyG Index Predicts Progression of Coronary Artery Calcification</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>To investigate the triglyceride-glucose (TyG) index association with coronary artery calcification (CAC) progression in adult Koreans.
Various cardiovascular risk factors and anthropometric profiles were assessed in 1,175 subjects who previously had a CAC evaluation at least twice by multidetector computed tomography in a health care center. The TyG index was determined using ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACSs) of subjects with detectable CAC at baseline.
CAC progression was seen in 312 subjects (27%) during 4.2 years follow-up. On the basis of the TyG index, subjects were stratified into three groups. Follow-up CACS and incidence of CAC progression were markedly elevated with rising TyG index tertile. Logistic regression analysis adjusted for various risk factors revealed an odds ratio for CAC progression of 1.82 (95% CI 1.20-2.77;
≤ 0.01) when the highest and lowest TyG index tertiles were compared.
The TyG index is an independent predictor of CAC progression.</description><subject>Adult</subject><subject>Anthropometry</subject><subject>Arteriosclerosis</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Calcification</subject><subject>Calcification (ectopic)</subject><subject>Calcium</subject><subject>Cardiovascular diseases</subject><subject>Computed tomography</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary vessels</subject><subject>Disease Progression</subject><subject>Fasting</subject><subject>Fasting - blood</subject><subject>Female</subject><subject>Glucose</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Incidence</subject><subject>Indexing</subject><subject>Laboratory testing</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>Regression analysis</subject><subject>Republic of Korea - epidemiology</subject><subject>Research design</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Triglycerides</subject><subject>Triglycerides - analysis</subject><subject>Triglycerides - blood</subject><subject>Vascular Calcification - blood</subject><subject>Vascular Calcification - diagnosis</subject><subject>Vascular Calcification - epidemiology</subject><subject>Veins & arteries</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1LAzEQhoMotlYP_gFZ8KKH1XxtNzmWpbaFgh7qOaTJRLZsNzXZFfvvTa168DQz8PAy74PQNcEPlLHy0RoiciIpPkFDIlmRFwUXp2iICZd5ISUdoIsYNxhjzoU4RwNGiKBc4iGaTxv40B3YbLWfZYvWwmf2EsDWpotp8W8BYqx9m3mXVT74Vod9NgkdpFHpxtSuNrpLwCU6c7qJcPUzR-j1abqq5vnyebaoJsvccMK7XDghtdWUmDUA1YJh54wBoSll2tKydNIV1Jbfl9OaOBBS4FRTCluUjo3Q3TF3F_x7D7FT2zoaaBrdgu-jooynmmPGeEJv_6Eb34c2facoLRkRYixJou6PlAk-xgBO7UK9TTUVweqgVx30qoPexN78JPbrLdg_8tcn-wLL9XRr</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Park, Kahui</creator><creator>Ahn, Chul Woo</creator><creator>Lee, Sang Bae</creator><creator>Kang, Shinae</creator><creator>Nam, Ji Sun</creator><creator>Lee, Byoung Kwon</creator><creator>Kim, Jung Hye</creator><creator>Park, Jong Suk</creator><general>American Diabetes Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9719-4774</orcidid><orcidid>https://orcid.org/0000-0002-5385-1373</orcidid></search><sort><creationdate>20190801</creationdate><title>Elevated TyG Index Predicts Progression of Coronary Artery Calcification</title><author>Park, Kahui ; Ahn, Chul Woo ; Lee, Sang Bae ; Kang, Shinae ; Nam, Ji Sun ; Lee, Byoung Kwon ; Kim, Jung Hye ; Park, Jong Suk</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-8f89ada21cbee2a830ffcce8a223ad277f9f52d723ad2faa1fe898023398d57f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Anthropometry</topic><topic>Arteriosclerosis</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - metabolism</topic><topic>Calcification</topic><topic>Calcification (ectopic)</topic><topic>Calcium</topic><topic>Cardiovascular diseases</topic><topic>Computed tomography</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary vessels</topic><topic>Disease Progression</topic><topic>Fasting</topic><topic>Fasting - blood</topic><topic>Female</topic><topic>Glucose</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Incidence</topic><topic>Indexing</topic><topic>Laboratory testing</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>Regression analysis</topic><topic>Republic of Korea - epidemiology</topic><topic>Research design</topic><topic>Retrospective Studies</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Triglycerides</topic><topic>Triglycerides - analysis</topic><topic>Triglycerides - blood</topic><topic>Vascular Calcification - blood</topic><topic>Vascular Calcification - diagnosis</topic><topic>Vascular Calcification - epidemiology</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Kahui</creatorcontrib><creatorcontrib>Ahn, Chul Woo</creatorcontrib><creatorcontrib>Lee, Sang Bae</creatorcontrib><creatorcontrib>Kang, Shinae</creatorcontrib><creatorcontrib>Nam, Ji Sun</creatorcontrib><creatorcontrib>Lee, Byoung Kwon</creatorcontrib><creatorcontrib>Kim, Jung Hye</creatorcontrib><creatorcontrib>Park, Jong Suk</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Kahui</au><au>Ahn, Chul Woo</au><au>Lee, Sang Bae</au><au>Kang, Shinae</au><au>Nam, Ji Sun</au><au>Lee, Byoung Kwon</au><au>Kim, Jung Hye</au><au>Park, Jong Suk</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated TyG Index Predicts Progression of Coronary Artery Calcification</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>42</volume><issue>8</issue><spage>1569</spage><epage>1573</epage><pages>1569-1573</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><abstract>To investigate the triglyceride-glucose (TyG) index association with coronary artery calcification (CAC) progression in adult Koreans.
Various cardiovascular risk factors and anthropometric profiles were assessed in 1,175 subjects who previously had a CAC evaluation at least twice by multidetector computed tomography in a health care center. The TyG index was determined using ln(fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). The CAC progression was defined as either incident CAC in a CAC-free population at baseline or an increase of ≥2.5 units between the square roots of the baseline and follow-up coronary artery calcium scores (CACSs) of subjects with detectable CAC at baseline.
CAC progression was seen in 312 subjects (27%) during 4.2 years follow-up. On the basis of the TyG index, subjects were stratified into three groups. Follow-up CACS and incidence of CAC progression were markedly elevated with rising TyG index tertile. Logistic regression analysis adjusted for various risk factors revealed an odds ratio for CAC progression of 1.82 (95% CI 1.20-2.77;
≤ 0.01) when the highest and lowest TyG index tertiles were compared.
The TyG index is an independent predictor of CAC progression.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>31182490</pmid><doi>10.2337/dc18-1920</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-9719-4774</orcidid><orcidid>https://orcid.org/0000-0002-5385-1373</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anthropometry Arteriosclerosis Blood Glucose - analysis Blood Glucose - metabolism Calcification Calcification (ectopic) Calcium Cardiovascular diseases Computed tomography Coronary artery Coronary Artery Disease - diagnosis Coronary Artery Disease - epidemiology Coronary Artery Disease - pathology Coronary vessels Disease Progression Fasting Fasting - blood Female Glucose Health risk assessment Health risks Health Status Indicators Humans Incidence Indexing Laboratory testing Longitudinal Studies Male Middle Aged Prognosis Regression analysis Republic of Korea - epidemiology Research design Retrospective Studies Risk analysis Risk Factors Triglycerides Triglycerides - analysis Triglycerides - blood Vascular Calcification - blood Vascular Calcification - diagnosis Vascular Calcification - epidemiology Veins & arteries |
| title | Elevated TyG Index Predicts Progression of Coronary Artery Calcification |
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