Progress of Antimicrobial Discovery Against the Major Cariogenic Pathogen Streptococcus mutans

Dental caries, also known as tooth decay, or cavities, remains a global public health issue. is considered the most significant contributor to dental caries. Its cariogenicity typically depends on its unique metabolic activity and lifestyle, including acid production, acid tolerance and biofilm form...

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Veröffentlicht in:	Current Issues in Molecular Biology 2019-01, Vol.32, p.601-644
Hauptverfasser:	Cui, Tao, Luo, Wenfu, Xu, Letong, Yang, Baoqiang, Zhao, Wen, Cang, Huaixing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - drug effects Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides - chemical synthesis Antimicrobial Cationic Peptides - pharmacology Biofilms - drug effects Biofilms - growth & development Biological Products - chemical synthesis Biological Products - isolation & purification Biological Products - pharmacology Dental Caries - drug therapy Dental Caries - metabolism Dental Caries - microbiology Dental Caries - pathology Dietary Carbohydrates - metabolism Drug Discovery Drug Repositioning Drug Resistance, Bacterial - drug effects Humans Oxidative Stress Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Streptococcal Infections - drug therapy Streptococcal Infections - metabolism Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus mutans - drug effects Streptococcus mutans - growth & development Streptococcus mutans - pathogenicity Structure-Activity Relationship Virulence
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