The role of 3D genome organization in development and cell differentiation

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically packaged inside the nucleus. This complex genome organization includes multiscale structural units of chromosome territories, compartments, topologically associating domains, which are often demarcated by arc...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2019-09, Vol.20 (9), p.535-550
Hauptverfasser:	Zheng, Hui, Xie, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/142 631/136/2086/1986 631/1647/2017/2214 631/337/572 Animals Biochemistry Biological activity Biological research Biology, Experimental Biomedical and Life Sciences Cancer Research Cell Biology Cell development (Biology) Cell Differentiation Cell division Chromatin Chromatin - genetics Chromatin - metabolism Chromosomes Cohesin Deoxyribonucleic acid Developmental Biology Developmental disabilities Differentiation (biology) DNA DNA biosynthesis Domains Embryogenesis Embryonic growth stage Eukaryotes Gametogenesis Gene expression Gene Expression Regulation Gene regulation Genome, Human Genomes Humans Life Sciences Meiosis Molecular dynamics Physiological aspects Review Article Stem Cells Stem Cells - metabolism Transcription Transcription, Genetic
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