The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults
Background/aim Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug–drug interactions, prescribing cascades, and potentially inap...
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| Veröffentlicht in: | Aging clinical and experimental research 2020-04, Vol.32 (4), p.681-687 |
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| container_title | Aging clinical and experimental research |
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| creator | Kucukdagli, Pinar Bahat, Gulistan Bay, Ilker Kilic, Cihan Oren, Meryem Merve Turkmen, Banu Ozulu Karan, Mehmet Akif |
| description | Background/aim
Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug–drug interactions, prescribing cascades, and potentially inappropriate medication (PIM) use. The purpose of this study was to evaluate the association between a common geriatric syndromes and PIM use among older adults.
Methods
Study participants were recruited among patients admitted to Istanbul Medical School Geriatrics outpatient clinic between June 2000 and June 2014 and were evaluated retrospectively by a geriatrician using the patients’ records according to Beers 2012 criteria.
Results
Among the 667 enrolled patients, 421 (63.1%) were women and 246 (36.9%) were men. The use of PIM was not associated with age or sex. Polypharmacy (OR 4.86, 95% CI 3.25–7.27,
p
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| doi_str_mv | 10.1007/s40520-019-01239-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2340038270</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2392289614</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-569417f3d104b7bba7c70451c1d4b4fbc2f43a24574e0f33a0f0d7a0be66d28c3</originalsourceid><addsrcrecordid>eNp9kctOxSAQhonReH8BF4bEjZvqcOnhdGmMt8TEja4JhanWtFChjZ63F8_xFhcuyMDwzc8wPyEHDE4YgDpNEkoOBbAqLy6q4m2NbDOVU3PBqvVf-y2yk9IzgGT5sEm2BGMVcIBtku6fkEbszNgGn57agdY4viJ6akPfB08fMbZmjK2laeFdDD0maryjQxjRj63pugVtvRmGGIYPEmmPrrVLPTolpCarPNLQOYzUuKkb0x7ZaEyXcP8z7pKHy4v78-vi9u7q5vzstrBClWNRzirJVCMcA1mrujbKKpAls8zJWja15Y0UhstSSYRGCAMNOGWgxtnM8bkVu-R4pZt7e5kwjbpvk8WuMx7DlDQXEkDMuYKMHv1Bn8MUfe4uUxXn82rGZKb4irIxpBSx0fnLvYkLzUB_WKJXluhsiV5aot9y0eGn9FTn0XyXfHmQAbECUr7yed4_b_8j-w4zFpld</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2392289614</pqid></control><display><type>article</type><title>The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults</title><source>SpringerNature Journals</source><creator>Kucukdagli, Pinar ; Bahat, Gulistan ; Bay, Ilker ; Kilic, Cihan ; Oren, Meryem Merve ; Turkmen, Banu Ozulu ; Karan, Mehmet Akif</creator><creatorcontrib>Kucukdagli, Pinar ; Bahat, Gulistan ; Bay, Ilker ; Kilic, Cihan ; Oren, Meryem Merve ; Turkmen, Banu Ozulu ; Karan, Mehmet Akif</creatorcontrib><description>Background/aim
Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug–drug interactions, prescribing cascades, and potentially inappropriate medication (PIM) use. The purpose of this study was to evaluate the association between a common geriatric syndromes and PIM use among older adults.
Methods
Study participants were recruited among patients admitted to Istanbul Medical School Geriatrics outpatient clinic between June 2000 and June 2014 and were evaluated retrospectively by a geriatrician using the patients’ records according to Beers 2012 criteria.
Results
Among the 667 enrolled patients, 421 (63.1%) were women and 246 (36.9%) were men. The use of PIM was not associated with age or sex. Polypharmacy (OR 4.86, 95% CI 3.25–7.27,
p
< 0.001), malnutrition (OR 2.69, 95% CI 1.52–4.76,
p
= 0.001), depression (OR 2.61, 95% CI 1.7–3.95,
p
< 0.001), presence of fall in the previous year (OR 2.24, 95% CI 1.51–3.32,
p
< 0.001), and dementia (OR 1.69, 95% CI 1.08–2.65,
p
= 0.021) were independently associated with the use of PIM.
Discussion/conclusions
The results of our study suggest that PIM use is independently associated with presence of polypharmacy, malnutrition, depression, falls and dementia in older outpatients. Identifying the association of inappropriate medication use with common geriatric syndromes in older people can help to prevent, delay, and reduce PIM use and related adverse health outcomes.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-019-01239-x</identifier><identifier>PMID: 31190200</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Dementia ; Geriatrics ; Geriatrics/Gerontology ; Malnutrition ; Medicine ; Medicine & Public Health ; Older people ; Original Article ; Polypharmacy</subject><ispartof>Aging clinical and experimental research, 2020-04, Vol.32 (4), p.681-687</ispartof><rights>Springer Nature Switzerland AG 2019</rights><rights>Springer Nature Switzerland AG 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-569417f3d104b7bba7c70451c1d4b4fbc2f43a24574e0f33a0f0d7a0be66d28c3</citedby><cites>FETCH-LOGICAL-c375t-569417f3d104b7bba7c70451c1d4b4fbc2f43a24574e0f33a0f0d7a0be66d28c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-019-01239-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-019-01239-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31190200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kucukdagli, Pinar</creatorcontrib><creatorcontrib>Bahat, Gulistan</creatorcontrib><creatorcontrib>Bay, Ilker</creatorcontrib><creatorcontrib>Kilic, Cihan</creatorcontrib><creatorcontrib>Oren, Meryem Merve</creatorcontrib><creatorcontrib>Turkmen, Banu Ozulu</creatorcontrib><creatorcontrib>Karan, Mehmet Akif</creatorcontrib><title>The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background/aim
Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug–drug interactions, prescribing cascades, and potentially inappropriate medication (PIM) use. The purpose of this study was to evaluate the association between a common geriatric syndromes and PIM use among older adults.
Methods
Study participants were recruited among patients admitted to Istanbul Medical School Geriatrics outpatient clinic between June 2000 and June 2014 and were evaluated retrospectively by a geriatrician using the patients’ records according to Beers 2012 criteria.
Results
Among the 667 enrolled patients, 421 (63.1%) were women and 246 (36.9%) were men. The use of PIM was not associated with age or sex. Polypharmacy (OR 4.86, 95% CI 3.25–7.27,
p
< 0.001), malnutrition (OR 2.69, 95% CI 1.52–4.76,
p
= 0.001), depression (OR 2.61, 95% CI 1.7–3.95,
p
< 0.001), presence of fall in the previous year (OR 2.24, 95% CI 1.51–3.32,
p
< 0.001), and dementia (OR 1.69, 95% CI 1.08–2.65,
p
= 0.021) were independently associated with the use of PIM.
Discussion/conclusions
The results of our study suggest that PIM use is independently associated with presence of polypharmacy, malnutrition, depression, falls and dementia in older outpatients. Identifying the association of inappropriate medication use with common geriatric syndromes in older people can help to prevent, delay, and reduce PIM use and related adverse health outcomes.</description><subject>Dementia</subject><subject>Geriatrics</subject><subject>Geriatrics/Gerontology</subject><subject>Malnutrition</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Older people</subject><subject>Original Article</subject><subject>Polypharmacy</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kctOxSAQhonReH8BF4bEjZvqcOnhdGmMt8TEja4JhanWtFChjZ63F8_xFhcuyMDwzc8wPyEHDE4YgDpNEkoOBbAqLy6q4m2NbDOVU3PBqvVf-y2yk9IzgGT5sEm2BGMVcIBtku6fkEbszNgGn57agdY4viJ6akPfB08fMbZmjK2laeFdDD0maryjQxjRj63pugVtvRmGGIYPEmmPrrVLPTolpCarPNLQOYzUuKkb0x7ZaEyXcP8z7pKHy4v78-vi9u7q5vzstrBClWNRzirJVCMcA1mrujbKKpAls8zJWja15Y0UhstSSYRGCAMNOGWgxtnM8bkVu-R4pZt7e5kwjbpvk8WuMx7DlDQXEkDMuYKMHv1Bn8MUfe4uUxXn82rGZKb4irIxpBSx0fnLvYkLzUB_WKJXluhsiV5aot9y0eGn9FTn0XyXfHmQAbECUr7yed4_b_8j-w4zFpld</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Kucukdagli, Pinar</creator><creator>Bahat, Gulistan</creator><creator>Bay, Ilker</creator><creator>Kilic, Cihan</creator><creator>Oren, Meryem Merve</creator><creator>Turkmen, Banu Ozulu</creator><creator>Karan, Mehmet Akif</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults</title><author>Kucukdagli, Pinar ; Bahat, Gulistan ; Bay, Ilker ; Kilic, Cihan ; Oren, Meryem Merve ; Turkmen, Banu Ozulu ; Karan, Mehmet Akif</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-569417f3d104b7bba7c70451c1d4b4fbc2f43a24574e0f33a0f0d7a0be66d28c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Dementia</topic><topic>Geriatrics</topic><topic>Geriatrics/Gerontology</topic><topic>Malnutrition</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Older people</topic><topic>Original Article</topic><topic>Polypharmacy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kucukdagli, Pinar</creatorcontrib><creatorcontrib>Bahat, Gulistan</creatorcontrib><creatorcontrib>Bay, Ilker</creatorcontrib><creatorcontrib>Kilic, Cihan</creatorcontrib><creatorcontrib>Oren, Meryem Merve</creatorcontrib><creatorcontrib>Turkmen, Banu Ozulu</creatorcontrib><creatorcontrib>Karan, Mehmet Akif</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kucukdagli, Pinar</au><au>Bahat, Gulistan</au><au>Bay, Ilker</au><au>Kilic, Cihan</au><au>Oren, Meryem Merve</au><au>Turkmen, Banu Ozulu</au><au>Karan, Mehmet Akif</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>32</volume><issue>4</issue><spage>681</spage><epage>687</epage><pages>681-687</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background/aim
Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug–drug interactions, prescribing cascades, and potentially inappropriate medication (PIM) use. The purpose of this study was to evaluate the association between a common geriatric syndromes and PIM use among older adults.
Methods
Study participants were recruited among patients admitted to Istanbul Medical School Geriatrics outpatient clinic between June 2000 and June 2014 and were evaluated retrospectively by a geriatrician using the patients’ records according to Beers 2012 criteria.
Results
Among the 667 enrolled patients, 421 (63.1%) were women and 246 (36.9%) were men. The use of PIM was not associated with age or sex. Polypharmacy (OR 4.86, 95% CI 3.25–7.27,
p
< 0.001), malnutrition (OR 2.69, 95% CI 1.52–4.76,
p
= 0.001), depression (OR 2.61, 95% CI 1.7–3.95,
p
< 0.001), presence of fall in the previous year (OR 2.24, 95% CI 1.51–3.32,
p
< 0.001), and dementia (OR 1.69, 95% CI 1.08–2.65,
p
= 0.021) were independently associated with the use of PIM.
Discussion/conclusions
The results of our study suggest that PIM use is independently associated with presence of polypharmacy, malnutrition, depression, falls and dementia in older outpatients. Identifying the association of inappropriate medication use with common geriatric syndromes in older people can help to prevent, delay, and reduce PIM use and related adverse health outcomes.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>31190200</pmid><doi>10.1007/s40520-019-01239-x</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Dementia Geriatrics Geriatrics/Gerontology Malnutrition Medicine Medicine & Public Health Older people Original Article Polypharmacy |
| title | The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults |
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