Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease

In patients with end-stage renal disease (ESRD), surgical aortic valve replacement is associated with higher early and late mortality, and adverse outcomes compared with patients without renal disease. Transcatheter aortic valve replacement (TAVR) offers another alternative, but there are limited re...

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Veröffentlicht in:	Journal of the American College of Cardiology 2019-06, Vol.73 (22), p.2806-2815
Hauptverfasser:	Szerlip, Molly, Zajarias, Alan, Vemalapalli, Sreekanth, Brennan, Matthew, Dai, Dadi, Maniar, Hersh, Lindman, Brian R., Brindis, Ralph, Carroll, John D., Hamandi, Mohanad, Edwards, Fred H., Grover, Fred, O’Brien, Sean, Peterson, Eric, Rumsfeld, John S., Shahian, Dave, Tuzcu, E. Murat, Holmes, David, Thourani, Vinod H., Mack, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aortic stenosis Aortic valve Aortic Valve Stenosis - complications Aortic Valve Stenosis - mortality Aortic Valve Stenosis - surgery Bleeding Cardiac arrhythmia Cardiology Comorbidity Complications Coronary vessels Demographics Demography Dialysis End-stage renal disease Female Follow-Up Studies Heart attacks Hemodialysis Hospital Mortality Hospitals Humans Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - mortality Kidney Failure, Chronic - physiopathology Male Medical personnel Medicare Mortality Patients Quality of life Reference Values Registries Renal Dialysis Risk Risk analysis Risk factors Stenosis Stroke Studies Success Thorax transcatheter aortic valve replacement Transcatheter Aortic Valve Replacement - methods Transcatheter Aortic Valve Replacement - mortality Treatment Outcome
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Zusammenfassung:	In patients with end-stage renal disease (ESRD), surgical aortic valve replacement is associated with higher early and late mortality, and adverse outcomes compared with patients without renal disease. Transcatheter aortic valve replacement (TAVR) offers another alternative, but there are limited reported outcomes. The purpose of this study was to determine the outcomes of TAVR in patients with ESRD. Among the first 72,631 patients with severe aortic stenosis (AS) treated with TAVR enrolled in the Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) TVT (Transcatheter Valve Therapies) registry, 3,053 (4.2%) patients had ESRD and were compared with patients who were not on dialysis for demographics, risk factors, and outcomes. Compared with the nondialysis patients, ESRD patients were younger (76 years vs. 83 years; p
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2019.03.496