Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword
Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux,...
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| Veröffentlicht in: | Cell metabolism 2019-06, Vol.29 (6), p.1236-1238 |
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| container_title | Cell metabolism |
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| creator | Hughey, Curtis C. Crawford, Peter A. |
| description | Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.
Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress. |
| doi_str_mv | 10.1016/j.cmet.2019.05.013 |
| format | Article |
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Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2019.05.013</identifier><identifier>PMID: 31167118</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Antioxidants ; Citric Acid Cycle ; Gluconeogenesis ; Liver ; Oxidation-Reduction ; Pyruvate Carboxylase ; Pyruvates</subject><ispartof>Cell metabolism, 2019-06, Vol.29 (6), p.1236-1238</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-d00a6eba92931e0a414f49f57b71a98196485eeb039026dc47cb76a7b6780e8a3</citedby><cites>FETCH-LOGICAL-c400t-d00a6eba92931e0a414f49f57b71a98196485eeb039026dc47cb76a7b6780e8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmet.2019.05.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31167118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hughey, Curtis C.</creatorcontrib><creatorcontrib>Crawford, Peter A.</creatorcontrib><title>Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.
Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.</description><subject>Antioxidants</subject><subject>Citric Acid Cycle</subject><subject>Gluconeogenesis</subject><subject>Liver</subject><subject>Oxidation-Reduction</subject><subject>Pyruvate Carboxylase</subject><subject>Pyruvates</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOw0AQRVcIRMLjByiQSxqbGa_t9SIaFJ4SCCRAlKt9jJEjB4ddO5C_x1ECJdVMce4dzWHsCCFBwOJ0mtgZdUkKKBPIE0C-xcYoeRqLLIXtYc9ziDPkOGJ7IUwBeMEl32UjjlgIxHLMzp6Wvl_ojqKJ9qb9XjY6UPRWU-NCpKPLtjcNxVfunVz0QJ02bVPb6Pmr9e6A7VS6CXS4mfvs9frqZXIb3z_e3E0u7mObAXSxA9AFGS1TyZFAZ5hVmaxyYQRqWaIssjInMsAlpIWzmbBGFFqYQpRApeb77GTdO_ftZ0-hU7M6WGoa_UFtH1TKhzs8x1QMaLpGrW9D8FSpua9n2i8Vglo5U1O1cqZWzhTkanA2hI43_b2ZkfuL_EoagPM1QMOXi5q8CramD0uu9mQ75dr6v_4fg_l7gA</recordid><startdate>20190604</startdate><enddate>20190604</enddate><creator>Hughey, Curtis C.</creator><creator>Crawford, Peter A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190604</creationdate><title>Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword</title><author>Hughey, Curtis C. ; Crawford, Peter A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-d00a6eba92931e0a414f49f57b71a98196485eeb039026dc47cb76a7b6780e8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antioxidants</topic><topic>Citric Acid Cycle</topic><topic>Gluconeogenesis</topic><topic>Liver</topic><topic>Oxidation-Reduction</topic><topic>Pyruvate Carboxylase</topic><topic>Pyruvates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hughey, Curtis C.</creatorcontrib><creatorcontrib>Crawford, Peter A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hughey, Curtis C.</au><au>Crawford, Peter A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2019-06-04</date><risdate>2019</risdate><volume>29</volume><issue>6</issue><spage>1236</spage><epage>1238</epage><pages>1236-1238</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | Antioxidants Citric Acid Cycle Gluconeogenesis Liver Oxidation-Reduction Pyruvate Carboxylase Pyruvates |
| title | Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword |
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