The small molecule AZD6244 inhibits dengue virus replication in vitro and protects against lethal challenge in a mouse model

Dengue virus (DENV) is the most common mosquito-borne viral disease. The World Health Organization estimates that 400 million new cases of dengue fever occur every year. Approximately 500,000 individuals develop severe and life-threatening complications from dengue fever, such as dengue shock syndro...

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Veröffentlicht in:	Archives of virology 2020-03, Vol.165 (3), p.671-681
Hauptverfasser:	de Oliveira, Leonardo C., Ribeiro, Aryádina M., Albarnaz, Jonas D., Torres, Alice A., Guimarães, Luís F. Z., Pinto, Amelia K., Parker, Scott, Doronin, Konstantin, Brien, James D., Buller, Mark R., Bonjardim, Cláudio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - therapeutic use Benzimidazoles - therapeutic use Biomedical and Life Sciences Biomedicine Cell Line Clinical trials Copy number Cricetinae Dengue fever Dengue hemorrhagic fever Dengue Virus - drug effects Dengue Virus - growth & development Disease Models, Animal Encephalitis Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors IL-1β Infectious Diseases Interleukin-1beta - blood Intravenous administration Life cycles Lung cancer Medical Microbiology Mice Morphogenesis Non-small cell lung carcinoma Original Article Replication Severe Dengue - prevention & control Severe Dengue - virology Signal Transduction - drug effects Spleen Tropical diseases Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-α Viral diseases Virology
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