1,2-Dichloroethane induces cerebellum granular cell apoptosis via mitochondrial pathway in vitro and in vivo

•1,2-DCE inhibited cell viability on HCGCs and induced apoptosis-mediated cell death.•1,2-DCE altered HCGC proteins expression of Caspase-3, cleaved Caspase-3, Cytochrome c, Bad.•1,2-DCE induced significantly shrunken, hypereosinophilic cytoplasm with nuclear pyknosis in CGCs.•Abnormal neurobehavior...

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Veröffentlicht in:	Toxicology letters 2020-04, Vol.322, p.87-97
Hauptverfasser:	Huang, Manqi, Zhong, Yizhou, Lin, Li, Liang, Boxuan, Liu, Jun, Jiang, Junying, Hu, Manjiang, Huang, Yuji, Lin, Xi, Lu, Lvliang, Bian, Ziwei, Zhong, Wenyu, Wu, Jiejiao, Zheng, Jiewei, Rong, Weifeng, Zhang, Yating, Jiang, Liang, Wu, Jieling, Zhang, Xin, Yang, Xingfen, Hu, Qiansheng, Huang, Zhenlie
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dichloroethane Animals Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Behavior, Animal - drug effects Cells, Cultured Cerebellar dysfunction Cerebellum - drug effects Cerebellum - metabolism Cerebellum - pathology Cerebellum - physiopathology Ethylene Dichlorides - toxicity Humans Locomotion - drug effects Male Membrane Potential, Mitochondrial - drug effects Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Neurons - drug effects Neurons - metabolism Neurons - pathology Neurotoxicity Risk Assessment Signal Transduction
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