Clinical research tools in pediatric oncology: challenges and opportunities
Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer...
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| Veröffentlicht in: | Cancer and metastasis reviews 2020-03, Vol.39 (1), p.149-160 |
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| creator | de Rojas, Teresa Neven, Anouk Towbin, Alexander J. Carceller, Fernando Bautista, Francisco Riedl, David Sodergren, Samantha Darlington, Anne-Sophie Fernandez-Teijeiro, Ana Moreno, Lucas |
| description | Survival for childhood cancers has improved significantly over the last decades. However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. These efforts will hopefully accelerate and improve the quality of pediatric oncology research in the upcoming years. |
| doi_str_mv | 10.1007/s10555-020-09856-z |
| format | Article |
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However, patient outcomes have plateaued over the last decade for difficult-to-treat diseases. With high cure rates, decreasing long-term toxicities and sequelae remains crucial. Since many advances in childhood cancer research come from the adult oncology world, one of the key areas is improving the adaptation of tools that are essential for clinical trial conduct that were developed for adults into pediatrics. These include tools to evaluate toxicity, quality of life, radiological response, statistical methodology, or indicators of cancer care quality. In this review, we present ongoing international efforts to validate and adapt these tools for children and adolescents and discuss remaining challenges. 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All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-283b5ceec513193395ca4ed17c155b7725db074449f217265d6b26ddc6c6dd513</citedby><cites>FETCH-LOGICAL-c513t-283b5ceec513193395ca4ed17c155b7725db074449f217265d6b26ddc6c6dd513</cites><orcidid>0000-0001-7749-8423</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10555-020-09856-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10555-020-09856-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31939050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Rojas, Teresa</creatorcontrib><creatorcontrib>Neven, Anouk</creatorcontrib><creatorcontrib>Towbin, Alexander J.</creatorcontrib><creatorcontrib>Carceller, Fernando</creatorcontrib><creatorcontrib>Bautista, Francisco</creatorcontrib><creatorcontrib>Riedl, David</creatorcontrib><creatorcontrib>Sodergren, Samantha</creatorcontrib><creatorcontrib>Darlington, Anne-Sophie</creatorcontrib><creatorcontrib>Fernandez-Teijeiro, Ana</creatorcontrib><creatorcontrib>Moreno, Lucas</creatorcontrib><title>Clinical research tools in pediatric oncology: challenges and opportunities</title><title>Cancer and metastasis reviews</title><addtitle>Cancer Metastasis Rev</addtitle><addtitle>Cancer Metastasis Rev</addtitle><description>Survival for childhood cancers has improved significantly over the last decades. 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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical and Life Sciences Biomedicine Cancer Cancer Research Children Clinical trials Complications Health risk assessment Medical colleges Medical research Oncology Oncology, Experimental Pediatrics Quality control Quality of life Toxicity |
| title | Clinical research tools in pediatric oncology: challenges and opportunities |
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