Antimalarial N 1 , N 3 -Dialkyldioxonaphthoimidazoliums: Synthesis, Biological Activity, and Structure-activity Relationships

Here we report the nanomolar potencies of , -dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant . Activity was dependent on the presence of the fused quinone-imidazolium entity and lipophilicity imparted by the N /N alkyl residues on the scaffold. Gametocytocidal activi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ACS medicinal chemistry letters 2020-01, Vol.11 (1), p.49-55
Hauptverfasser:	Ahenkorah, Stephen, Coertzen, Dina, Tong, Jie Xin, Fridianto, Kevin, Wittlin, Sergio, Birkholtz, Lyn-Marie, Tan, Kevin S W, Lam, Yulin, Go, Mei-Lin, Haynes, Richard K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!