C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents

African trypanosomiasis, a deadly infectious disease caused by the protozoan Trypanosoma brucei spp., is spread to new hosts by bites of infected tsetse flies. Currently approved therapies all have their specific drawbacks, prompting a search for novel therapeutic agents. T. brucei lacks the enzymes...

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Veröffentlicht in:	European journal of medicinal chemistry 2020-02, Vol.188, p.112018-112018, Article 112018
Hauptverfasser:	Hulpia, Fabian, Bouton, Jakob, Campagnaro, Gustavo D., Alfayez, Ibrahim A., Mabille, Dorien, Maes, Louis, de Koning, Harry P., Caljon, Guy, Van Calenbergh, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Inosine nucleoside analogues Parasite nucleoside transporter Trypanosoma brucei
Online-Zugang:	Volltext
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