VHL enhances 9-cis-retinoic acid treatment by down-regulating retinoid X receptor α in renal cell carcinomas

Renal cell carcinoma (RCC) is the most common malignant kidney tumors in adults. Von Hippel-Lindau (VHL) gene is deficient in >50% of RCC cases, but the role of VHL as a potential therapeutic target in RCC has not been well established. In the present study, 9-cis-Retinoic acid, which is a potent...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-03, Vol.523 (2), p.535-541
Hauptverfasser:	Wang, Fen, Wang, Long-Sheng, Gao, Yao-Hui, Yao, Xu-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	9-cis-Retinoic acid Renal cell carcinomas Retinoid X receptor α Von Hippel-Lindau
Online-Zugang:	Volltext
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