High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study
This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured i...
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| Veröffentlicht in: | Indoor air 2020-05, Vol.30 (3), p.512-520 |
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| creator | Braz, Mariana G. Carvalho, Lorena I. M. Chen, Chung‐Yen O. Blumberg, Jeffrey B. Souza, Kátina M. Arruda, Nayara M. Filho, Daniel A. A. Resende, Ludimila O. Faria, Renata T. B. G. Canário, Clara d'A. Carvalho, Lídia R. Corrêa, Camila R. Braz, José Reinaldo C. Braz, Leandro G. |
| description | This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus‐MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL‐17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3‐fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure. |
| doi_str_mv | 10.1111/ina.12643 |
| format | Article |
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M. ; Chen, Chung‐Yen O. ; Blumberg, Jeffrey B. ; Souza, Kátina M. ; Arruda, Nayara M. ; Filho, Daniel A. A. ; Resende, Ludimila O. ; Faria, Renata T. B. G. ; Canário, Clara d'A. ; Carvalho, Lídia R. ; Corrêa, Camila R. ; Braz, José Reinaldo C. ; Braz, Leandro G.</creator><creatorcontrib>Braz, Mariana G. ; Carvalho, Lorena I. M. ; Chen, Chung‐Yen O. ; Blumberg, Jeffrey B. ; Souza, Kátina M. ; Arruda, Nayara M. ; Filho, Daniel A. A. ; Resende, Ludimila O. ; Faria, Renata T. B. G. ; Canário, Clara d'A. ; Carvalho, Lídia R. ; Corrêa, Camila R. ; Braz, José Reinaldo C. ; Braz, Leandro G.</creatorcontrib><description>This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus‐MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL‐17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3‐fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.</description><identifier>ISSN: 0905-6947</identifier><identifier>EISSN: 1600-0668</identifier><identifier>DOI: 10.1111/ina.12643</identifier><identifier>PMID: 31930534</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Air pollution ; Air pollution measurements ; Anesthetics ; Antioxidants ; Biomarkers ; Chromosome aberrations ; Cross-sectional studies ; Cytokines ; Damage ; Deoxyribonucleic acid ; DNA ; DNA damage ; Exposure ; Gases ; Genomic instability ; Health hazards ; Impact analysis ; indoor air pollution ; Inflammation ; inhalation anesthetics ; Isoflurane ; Lipids ; Nitrous oxide ; Occupational exposure ; Occupational health ; Oxidation ; Oxidative stress ; Physicians ; Scavenging ; Sevoflurane ; work environment</subject><ispartof>Indoor air, 2020-05, Vol.30 (3), p.512-520</ispartof><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3533-c27533bd5660d512e68bac1d4e6222f329ecf21593a08cebef6fb0c968b5e4153</citedby><cites>FETCH-LOGICAL-c3533-c27533bd5660d512e68bac1d4e6222f329ecf21593a08cebef6fb0c968b5e4153</cites><orcidid>0000-0003-4413-226X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fina.12643$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fina.12643$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31930534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braz, Mariana G.</creatorcontrib><creatorcontrib>Carvalho, Lorena I. M.</creatorcontrib><creatorcontrib>Chen, Chung‐Yen O.</creatorcontrib><creatorcontrib>Blumberg, Jeffrey B.</creatorcontrib><creatorcontrib>Souza, Kátina M.</creatorcontrib><creatorcontrib>Arruda, Nayara M.</creatorcontrib><creatorcontrib>Filho, Daniel A. A.</creatorcontrib><creatorcontrib>Resende, Ludimila O.</creatorcontrib><creatorcontrib>Faria, Renata T. B. G.</creatorcontrib><creatorcontrib>Canário, Clara d'A.</creatorcontrib><creatorcontrib>Carvalho, Lídia R.</creatorcontrib><creatorcontrib>Corrêa, Camila R.</creatorcontrib><creatorcontrib>Braz, José Reinaldo C.</creatorcontrib><creatorcontrib>Braz, Leandro G.</creatorcontrib><title>High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study</title><title>Indoor air</title><addtitle>Indoor Air</addtitle><description>This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus‐MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL‐17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3‐fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.</description><subject>Air pollution</subject><subject>Air pollution measurements</subject><subject>Anesthetics</subject><subject>Antioxidants</subject><subject>Biomarkers</subject><subject>Chromosome aberrations</subject><subject>Cross-sectional studies</subject><subject>Cytokines</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Exposure</subject><subject>Gases</subject><subject>Genomic instability</subject><subject>Health hazards</subject><subject>Impact analysis</subject><subject>indoor air pollution</subject><subject>Inflammation</subject><subject>inhalation anesthetics</subject><subject>Isoflurane</subject><subject>Lipids</subject><subject>Nitrous oxide</subject><subject>Occupational exposure</subject><subject>Occupational health</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Physicians</subject><subject>Scavenging</subject><subject>Sevoflurane</subject><subject>work environment</subject><issn>0905-6947</issn><issn>1600-0668</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kb1uFDEURi0EIkug4AWQJRooJvHP2LumW0WBRIqggXrksa93Hc2MF98ZJdPxCGl4QZ4E726gQMLNle3jI3_6CHnN2Rkv6zwO9owLXcsnZME1YxXTevWULJhhqtKmXp6QF4i3jPGlNPI5OZHcSKZkvSA_r-JmS10aHAxjtmNMA9IU6J3FEagdAMctjNHRjUVAGgc_OaAbGA6H3vZ2s8d8uQmd7fuDoWzobjtjdNEWHdzvEoKnIWU6bjMAncFm_EDX1OWE-OvHA4LbP7QdxXHy80vyLNgO4dXjPCXfPl5-vbiqbr58ur5Y31ROKikrJ5ZltF5pzbziAvSqtY77GrQQIkhhwAXBlZGWrRy0EHRomTMFU1BzJU_Ju6N3l9P3qWRt-ogOuq4ETxM2QsoV07wWpqBv_0Fv05TLj_eUqVXRLXWh3h-pQ7AModnl2Ns8N5w1-66a0lVz6Kqwbx6NU9uD_0v-KacA50fgLnYw_9_UXH9eH5W_ARX1oNs</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Braz, Mariana G.</creator><creator>Carvalho, Lorena I. 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M. ; Chen, Chung‐Yen O. ; Blumberg, Jeffrey B. ; Souza, Kátina M. ; Arruda, Nayara M. ; Filho, Daniel A. A. ; Resende, Ludimila O. ; Faria, Renata T. B. 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G.</creatorcontrib><creatorcontrib>Canário, Clara d'A.</creatorcontrib><creatorcontrib>Carvalho, Lídia R.</creatorcontrib><creatorcontrib>Corrêa, Camila R.</creatorcontrib><creatorcontrib>Braz, José Reinaldo C.</creatorcontrib><creatorcontrib>Braz, Leandro G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Indoor air</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braz, Mariana G.</au><au>Carvalho, Lorena I. M.</au><au>Chen, Chung‐Yen O.</au><au>Blumberg, Jeffrey B.</au><au>Souza, Kátina M.</au><au>Arruda, Nayara M.</au><au>Filho, Daniel A. A.</au><au>Resende, Ludimila O.</au><au>Faria, Renata T. B. G.</au><au>Canário, Clara d'A.</au><au>Carvalho, Lídia R.</au><au>Corrêa, Camila R.</au><au>Braz, José Reinaldo C.</au><au>Braz, Leandro G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study</atitle><jtitle>Indoor air</jtitle><addtitle>Indoor Air</addtitle><date>2020-05</date><risdate>2020</risdate><volume>30</volume><issue>3</issue><spage>512</spage><epage>520</epage><pages>512-520</pages><issn>0905-6947</issn><eissn>1600-0668</eissn><abstract>This cross‐sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of their medical residency. Concentrations of waste anesthetic gases were measured in the operating rooms to assess anesthetic pollution. The exposed group comprised individuals occupationally exposed to inhalational anesthetics, while the control group comprised individuals without anesthetic exposure. We quantified DNA damage; genetic instability (micronucleus‐MN); protein, lipid, and DNA oxidation; antioxidant activities; and proinflammatory cytokine levels. Trace concentrations of anesthetics (isoflurane: 5.3 ± 2.5 ppm, sevoflurane: 9.7 ± 5.9 ppm, and nitrous oxide: 180 ± 150 ppm) were above international recommended thresholds. Basal DNA damage and IL‐17A were significantly higher in the exposed group [27 ± 20 a.u. and 20.7(19.1;31.8) pg/mL, respectively] compared to the control group [17 ± 11 a.u. and 19.0(18.9;19.5) pg/mL, respectively], and MN frequency was slightly increased in the exposed physicians (2.3‐fold). No significant difference was observed regarding oxidative stress biomarkers. The findings highlight the genetic and inflammatory risks in young physicians exposed to inhalational agents in operating rooms lacking adequate scavenging systems. This potential health hazard can accompany these subjects throughout their professional lives and reinforces the need to reduce ambient air pollution and consequently, occupational exposure.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>31930534</pmid><doi>10.1111/ina.12643</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4413-226X</orcidid></addata></record> |
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| subjects | Air pollution Air pollution measurements Anesthetics Antioxidants Biomarkers Chromosome aberrations Cross-sectional studies Cytokines Damage Deoxyribonucleic acid DNA DNA damage Exposure Gases Genomic instability Health hazards Impact analysis indoor air pollution Inflammation inhalation anesthetics Isoflurane Lipids Nitrous oxide Occupational exposure Occupational health Oxidation Oxidative stress Physicians Scavenging Sevoflurane work environment |
| title | High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross‐sectional study |
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