Editorial commentary: Vagal nerve stimulation for myocardial ischemia-reperfusion injury: Hope or Hype?
Early coronary revascularization, with concomitant medical management, is the mainstay of therapy to reduce infarct size and improve cardiovascular outcomes including survival in patients with acute ischemic events. Disruption in vagal/sympathetic balance during ischemia may contribute to further da...
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| Veröffentlicht in: | Trends in cardiovascular medicine 2020-11, Vol.30 (8), p.489-490 |
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| container_title | Trends in cardiovascular medicine |
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| creator | Statz, Giselle M. Olshansky, Brian |
| description | Early coronary revascularization, with concomitant medical management, is the mainstay of therapy to reduce infarct size and improve cardiovascular outcomes including survival in patients with acute ischemic events. Disruption in vagal/sympathetic balance during ischemia may contribute to further damage. [...]vagal nerve stimulation (VNS) in animal models and in humans may be cardioprotective [2–9]. The myriad of potential VNS programming poses a barrier to standardizing investigations, and the seemingly infinite number of computations makes discovering the optimal settings for clinical outcomes an overwhelming task.VNS for acute myocardial injury – the bottom line Pre-clinical animal models [2–7,9] show promising results for use of VNS in ameliorating IRI. |
| doi_str_mv | 10.1016/j.tcm.2019.12.004 |
| format | Article |
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| ispartof | Trends in cardiovascular medicine, 2020-11, Vol.30 (8), p.489-490 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animal models Cardiac arrhythmia Heart Heart attacks Heart failure Humans Inflammation Ischemia Myocardial ischemia Myocardial Reperfusion Injury - diagnosis Myocardial Reperfusion Injury - prevention & control Nervous system Reperfusion Vagus Nerve Vagus Nerve Stimulation - adverse effects |
| title | Editorial commentary: Vagal nerve stimulation for myocardial ischemia-reperfusion injury: Hope or Hype? |
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