Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas
Background: Based on the new TNM classification, differentiated thyroid carcinomas with extrathyroidal extension (ETE) into the strap muscles are designated as T3b. The current study analyzed the clinical significance of this new stage in patients with papillary thyroid cancer (PTC). Subjects and Me...
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| Veröffentlicht in: | Thyroid (New York, N.Y.) N.Y.), 2020-01, Vol.30 (1), p.57-64 |
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| container_title | Thyroid (New York, N.Y.) |
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| creator | Li, Genpeng Li, Ruicen Song, Linlin Chen, Wenjie Jiang, Ke Tang, Huairong Wei, Tao Li, Zhihui Gong, Rixiang Lei, Jianyong Zhu, Jingqiang |
| description | Background:
Based on the new TNM classification, differentiated thyroid carcinomas with extrathyroidal extension (ETE) into the strap muscles are designated as T3b. The current study analyzed the clinical significance of this new stage in patients with papillary thyroid cancer (PTC).
Subjects and Methods:
This retrospective cohort study included 4045 eligible PTC patients. The patients were divided into four groups according to the extent of ETE: no ETE, ETE into perithyroidal tissue, T3b (ETE into the strap muscles), and ETE beyond the strap muscles. Differences in the clinical characteristics and prognosis of the four groups were assessed.
Results:
Of these 4045 patients, 2300 (56.9%) had no ETE, 1004 (24.8%) had ETE into perithyroidal tissue, 371 (9.2%) had ETE into the strap muscles, and 370 (9.1%) had ETE beyond the strap muscles. Tumor size, multifocality, lymph node metastasis (LNM), distant metastasis (DM), recurrence, and recurrence-free survival (RFS) between patients with ETE into perithyroidal tissue and patients without ETE did not show differences, but significant differences were observed between patients with T3b and patients without ETE, and only patients with ETE beyond the strap muscles had significantly worse overall survival (OS) than the other three groups. However, T3b did not independently predict worse RFS in univariable and multivariable analyses.
Conclusions:
T3b, distinguished from minimal ETE, may be related to larger tumor size, higher prevalence of multifocality, LNM, DM, recurrence, and worse RFS than no ETE, but it may not affect OS and may not independently predict recurrence in PTC patients. |
| doi_str_mv | 10.1089/thy.2018.0801 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2337001301</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2337001301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-a3f4e6b5ab5402b88b918d75771e19a9fb127aee34a6d17c6012b799f2a45a173</originalsourceid><addsrcrecordid>eNqFkM9LwzAYQIMobk6PXiVHL51J0zTpUcbUwWSC8xy-tqmLtGlNWnH_vSmbXoVAfj0eHw-ha0rmlMjsrt_t5zGhck4koSdoSjkXUUaEOA1nwkkkYp5O0IX3H4TQVAp2jiaMSkYkz6Zot2q62hTQm9Z63FZ4-d07CFLXmhLq8aqtD594Zb-gNPYdb2y9x_1O49dAdvh58EWtPTYWv0Bn6hrcHm8PArwAVxjbNuAv0VkFtddXx32G3h6W28VTtN48rhb366hICOsjYFWi05xDzhMS51LmGZWl4EJQTTPIqpzGArRmCaQlFUVKaJyLLKtiSDhQwWbo9uDtXPs5aN-rxvhCh7GsbgevYsZECMHCmqHogBau9d7pSnXONGF8RYka46rQQY1x1Rg38DdH9ZA3uvyjf2sGgB2A8RmsrY3Otev_0f4A6yCHvQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2337001301</pqid></control><display><type>article</type><title>Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Li, Genpeng ; Li, Ruicen ; Song, Linlin ; Chen, Wenjie ; Jiang, Ke ; Tang, Huairong ; Wei, Tao ; Li, Zhihui ; Gong, Rixiang ; Lei, Jianyong ; Zhu, Jingqiang</creator><creatorcontrib>Li, Genpeng ; Li, Ruicen ; Song, Linlin ; Chen, Wenjie ; Jiang, Ke ; Tang, Huairong ; Wei, Tao ; Li, Zhihui ; Gong, Rixiang ; Lei, Jianyong ; Zhu, Jingqiang</creatorcontrib><description>Background:
Based on the new TNM classification, differentiated thyroid carcinomas with extrathyroidal extension (ETE) into the strap muscles are designated as T3b. The current study analyzed the clinical significance of this new stage in patients with papillary thyroid cancer (PTC).
Subjects and Methods:
This retrospective cohort study included 4045 eligible PTC patients. The patients were divided into four groups according to the extent of ETE: no ETE, ETE into perithyroidal tissue, T3b (ETE into the strap muscles), and ETE beyond the strap muscles. Differences in the clinical characteristics and prognosis of the four groups were assessed.
Results:
Of these 4045 patients, 2300 (56.9%) had no ETE, 1004 (24.8%) had ETE into perithyroidal tissue, 371 (9.2%) had ETE into the strap muscles, and 370 (9.1%) had ETE beyond the strap muscles. Tumor size, multifocality, lymph node metastasis (LNM), distant metastasis (DM), recurrence, and recurrence-free survival (RFS) between patients with ETE into perithyroidal tissue and patients without ETE did not show differences, but significant differences were observed between patients with T3b and patients without ETE, and only patients with ETE beyond the strap muscles had significantly worse overall survival (OS) than the other three groups. However, T3b did not independently predict worse RFS in univariable and multivariable analyses.
Conclusions:
T3b, distinguished from minimal ETE, may be related to larger tumor size, higher prevalence of multifocality, LNM, DM, recurrence, and worse RFS than no ETE, but it may not affect OS and may not independently predict recurrence in PTC patients.</description><identifier>ISSN: 1050-7256</identifier><identifier>EISSN: 1557-9077</identifier><identifier>DOI: 10.1089/thy.2018.0801</identifier><identifier>PMID: 31830859</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc., publishers</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Papillary - diagnosis ; Carcinoma, Papillary - pathology ; Female ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Multivariate Analysis ; Muscle, Skeletal - pathology ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Postoperative Period ; Prognosis ; Retrospective Studies ; Thyroid Cancer and Nodules ; Thyroid Cancer, Papillary - diagnosis ; Thyroid Cancer, Papillary - pathology ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - pathology ; Thyroidectomy ; Young Adult</subject><ispartof>Thyroid (New York, N.Y.), 2020-01, Vol.30 (1), p.57-64</ispartof><rights>2020, Mary Ann Liebert, Inc., publishers</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-a3f4e6b5ab5402b88b918d75771e19a9fb127aee34a6d17c6012b799f2a45a173</citedby><cites>FETCH-LOGICAL-c403t-a3f4e6b5ab5402b88b918d75771e19a9fb127aee34a6d17c6012b799f2a45a173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31830859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Genpeng</creatorcontrib><creatorcontrib>Li, Ruicen</creatorcontrib><creatorcontrib>Song, Linlin</creatorcontrib><creatorcontrib>Chen, Wenjie</creatorcontrib><creatorcontrib>Jiang, Ke</creatorcontrib><creatorcontrib>Tang, Huairong</creatorcontrib><creatorcontrib>Wei, Tao</creatorcontrib><creatorcontrib>Li, Zhihui</creatorcontrib><creatorcontrib>Gong, Rixiang</creatorcontrib><creatorcontrib>Lei, Jianyong</creatorcontrib><creatorcontrib>Zhu, Jingqiang</creatorcontrib><title>Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas</title><title>Thyroid (New York, N.Y.)</title><addtitle>Thyroid</addtitle><description>Background:
Based on the new TNM classification, differentiated thyroid carcinomas with extrathyroidal extension (ETE) into the strap muscles are designated as T3b. The current study analyzed the clinical significance of this new stage in patients with papillary thyroid cancer (PTC).
Subjects and Methods:
This retrospective cohort study included 4045 eligible PTC patients. The patients were divided into four groups according to the extent of ETE: no ETE, ETE into perithyroidal tissue, T3b (ETE into the strap muscles), and ETE beyond the strap muscles. Differences in the clinical characteristics and prognosis of the four groups were assessed.
Results:
Of these 4045 patients, 2300 (56.9%) had no ETE, 1004 (24.8%) had ETE into perithyroidal tissue, 371 (9.2%) had ETE into the strap muscles, and 370 (9.1%) had ETE beyond the strap muscles. Tumor size, multifocality, lymph node metastasis (LNM), distant metastasis (DM), recurrence, and recurrence-free survival (RFS) between patients with ETE into perithyroidal tissue and patients without ETE did not show differences, but significant differences were observed between patients with T3b and patients without ETE, and only patients with ETE beyond the strap muscles had significantly worse overall survival (OS) than the other three groups. However, T3b did not independently predict worse RFS in univariable and multivariable analyses.
Conclusions:
T3b, distinguished from minimal ETE, may be related to larger tumor size, higher prevalence of multifocality, LNM, DM, recurrence, and worse RFS than no ETE, but it may not affect OS and may not independently predict recurrence in PTC patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Papillary - diagnosis</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Muscle, Skeletal - pathology</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Postoperative Period</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Thyroid Cancer and Nodules</subject><subject>Thyroid Cancer, Papillary - diagnosis</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Neoplasms - diagnosis</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroidectomy</subject><subject>Young Adult</subject><issn>1050-7256</issn><issn>1557-9077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9LwzAYQIMobk6PXiVHL51J0zTpUcbUwWSC8xy-tqmLtGlNWnH_vSmbXoVAfj0eHw-ha0rmlMjsrt_t5zGhck4koSdoSjkXUUaEOA1nwkkkYp5O0IX3H4TQVAp2jiaMSkYkz6Zot2q62hTQm9Z63FZ4-d07CFLXmhLq8aqtD594Zb-gNPYdb2y9x_1O49dAdvh58EWtPTYWv0Bn6hrcHm8PArwAVxjbNuAv0VkFtddXx32G3h6W28VTtN48rhb366hICOsjYFWi05xDzhMS51LmGZWl4EJQTTPIqpzGArRmCaQlFUVKaJyLLKtiSDhQwWbo9uDtXPs5aN-rxvhCh7GsbgevYsZECMHCmqHogBau9d7pSnXONGF8RYka46rQQY1x1Rg38DdH9ZA3uvyjf2sGgB2A8RmsrY3Otev_0f4A6yCHvQ</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Li, Genpeng</creator><creator>Li, Ruicen</creator><creator>Song, Linlin</creator><creator>Chen, Wenjie</creator><creator>Jiang, Ke</creator><creator>Tang, Huairong</creator><creator>Wei, Tao</creator><creator>Li, Zhihui</creator><creator>Gong, Rixiang</creator><creator>Lei, Jianyong</creator><creator>Zhu, Jingqiang</creator><general>Mary Ann Liebert, Inc., publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200101</creationdate><title>Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas</title><author>Li, Genpeng ; Li, Ruicen ; Song, Linlin ; Chen, Wenjie ; Jiang, Ke ; Tang, Huairong ; Wei, Tao ; Li, Zhihui ; Gong, Rixiang ; Lei, Jianyong ; Zhu, Jingqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-a3f4e6b5ab5402b88b918d75771e19a9fb127aee34a6d17c6012b799f2a45a173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Papillary - diagnosis</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Muscle, Skeletal - pathology</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Postoperative Period</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Thyroid Cancer and Nodules</topic><topic>Thyroid Cancer, Papillary - diagnosis</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroidectomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Genpeng</creatorcontrib><creatorcontrib>Li, Ruicen</creatorcontrib><creatorcontrib>Song, Linlin</creatorcontrib><creatorcontrib>Chen, Wenjie</creatorcontrib><creatorcontrib>Jiang, Ke</creatorcontrib><creatorcontrib>Tang, Huairong</creatorcontrib><creatorcontrib>Wei, Tao</creatorcontrib><creatorcontrib>Li, Zhihui</creatorcontrib><creatorcontrib>Gong, Rixiang</creatorcontrib><creatorcontrib>Lei, Jianyong</creatorcontrib><creatorcontrib>Zhu, Jingqiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thyroid (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Genpeng</au><au>Li, Ruicen</au><au>Song, Linlin</au><au>Chen, Wenjie</au><au>Jiang, Ke</au><au>Tang, Huairong</au><au>Wei, Tao</au><au>Li, Zhihui</au><au>Gong, Rixiang</au><au>Lei, Jianyong</au><au>Zhu, Jingqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas</atitle><jtitle>Thyroid (New York, N.Y.)</jtitle><addtitle>Thyroid</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>30</volume><issue>1</issue><spage>57</spage><epage>64</epage><pages>57-64</pages><issn>1050-7256</issn><eissn>1557-9077</eissn><abstract>Background:
Based on the new TNM classification, differentiated thyroid carcinomas with extrathyroidal extension (ETE) into the strap muscles are designated as T3b. The current study analyzed the clinical significance of this new stage in patients with papillary thyroid cancer (PTC).
Subjects and Methods:
This retrospective cohort study included 4045 eligible PTC patients. The patients were divided into four groups according to the extent of ETE: no ETE, ETE into perithyroidal tissue, T3b (ETE into the strap muscles), and ETE beyond the strap muscles. Differences in the clinical characteristics and prognosis of the four groups were assessed.
Results:
Of these 4045 patients, 2300 (56.9%) had no ETE, 1004 (24.8%) had ETE into perithyroidal tissue, 371 (9.2%) had ETE into the strap muscles, and 370 (9.1%) had ETE beyond the strap muscles. Tumor size, multifocality, lymph node metastasis (LNM), distant metastasis (DM), recurrence, and recurrence-free survival (RFS) between patients with ETE into perithyroidal tissue and patients without ETE did not show differences, but significant differences were observed between patients with T3b and patients without ETE, and only patients with ETE beyond the strap muscles had significantly worse overall survival (OS) than the other three groups. However, T3b did not independently predict worse RFS in univariable and multivariable analyses.
Conclusions:
T3b, distinguished from minimal ETE, may be related to larger tumor size, higher prevalence of multifocality, LNM, DM, recurrence, and worse RFS than no ETE, but it may not affect OS and may not independently predict recurrence in PTC patients.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc., publishers</pub><pmid>31830859</pmid><doi>10.1089/thy.2018.0801</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Carcinoma, Papillary - diagnosis Carcinoma, Papillary - pathology Female Humans Kaplan-Meier Estimate Lymphatic Metastasis Male Middle Aged Multivariate Analysis Muscle, Skeletal - pathology Neoplasm Metastasis Neoplasm Recurrence, Local Neoplasm Staging Postoperative Period Prognosis Retrospective Studies Thyroid Cancer and Nodules Thyroid Cancer, Papillary - diagnosis Thyroid Cancer, Papillary - pathology Thyroid Neoplasms - diagnosis Thyroid Neoplasms - pathology Thyroidectomy Young Adult |
| title | Implications of Extrathyroidal Extension Invading Only the Strap Muscles in Papillary Thyroid Carcinomas |
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