Gallic Acid Attenuated LPS-Induced Neuroinflammation: Protein Aggregation and Necroptosis

Gallic acid (3,4,5-trihydroxybenzoic acid, GA), a phenolic acid, is ubiquitous in almost all parts of the plant. In the present study, a neuroinflammatory rat model using intranigral infusion of lipopolysaccharides (LPS, 4 μg/μL) was employed to study the neuroprotective effect of GA which was orall...

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Veröffentlicht in:	Molecular neurobiology 2020-01, Vol.57 (1), p.96-104
Hauptverfasser:	Liu, Yu-Ling, Hsu, Chia-Chi, Huang, Hui-Ju, Chang, Chih-Jung, Sun, Shu-Hui, Lin, Anya Maan-Yuh
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Astrocytes Biomarkers Biomedical and Life Sciences Biomedicine Brain Caspase-3 Cell Biology Cell culture Cell death Dopamine receptors Gallic acid Gene expression Glial fibrillary acidic protein Glutathione Heme Heme oxygenase (decyclizing) Incubation Inflammation Iron Kinases Lipid peroxidation Lipopolysaccharides Microglia Microglial cells mRNA Necroptosis Neurobiology Neurodegeneration Neurodegenerative diseases Neurology Neurosciences Nitric oxide Oxidative stress Peroxidation Phenols Protein kinase Rodents Vitamin E
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