Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment
Objective To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine (CM) formula could improve the efficacy of intrapleural administration of interleukin-2 (IL-2) in treatment of malignant pleural effusion (MPE). Methods A total of 110 eligible participants...
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| Veröffentlicht in: | Chinese journal of integrative medicine 2020-04, Vol.26 (4), p.263-269 |
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| container_title | Chinese journal of integrative medicine |
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| creator | Tian, Ai-ping Yin, Yu-kun Yu, Lei Yang, Bo-yan Li, Ning Li, Jian-ying Bian, Zhi-min Hu, Shang-ying Weng, Chun-xiao Feng, Li |
| description | Objective
To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine (CM) formula could improve the efficacy of intrapleural administration of interleukin-2 (IL-2) in treatment of malignant pleural effusion (MPE).
Methods
A total of 110 eligible participants were randomized into the low-frequency sonophoresis (LFS) of CM (LSF/CM) group (55 cases) and the control group (55 cases) by simple randomization using a random number table. The control group was treated with an intrapleural administration of IL-2; and the LFS/CM group was treated with LFS of a CM gel formulation, combined with the same IL-2 injection as in the control group. The CM formula consisted of
Semen Lepidii, Semen Sinapis, Ramulus Cinnamomi, Poriacocos, Herba Lycopi
, and
Radix Paeoniae Rubra.
After 2-week treatment, the therapeutic outcome was determined by the change of the amount of MPE, which was evaluated by B-scan ultrasound and/or chest X-ray, and the change of quality of life (QOL) scores, which were evaluated by the Eastern Cooperative Oncology Group (ECOG) performance status.
Results
A significantly higher objective remission rate (ORR) was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone (
P
=0.049). In addition, more patients in the LFS/CM group than in the control group had an improved QOL score (
P
=0.048), and no patients in the LFS/CM group had a reduced QOL.
Conclusion
: LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients. |
| doi_str_mv | 10.1007/s11655-019-3167-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2336991780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2336991780</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-de49029350546bd04d8f67a913e99d95c33a5b3f0a8847ff4e871e7a7971e4a23</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhC0EouXxA7ggH7kE7PgVH1HVAlIrkICz5SZrCErsYicg_j2uChw57Ug7M9r9EDqj5JISoq4SpVKIglBdMCpVofbQlGrNCsJJuZ-1VGXWVEzQUUpvhAgliThEE0Y551LqKdosw2exiPA-gq-_8GPwYfMaIqQ24eDw7LX1kACvoGnrLPEixH7sLL7rNzF8QMJz59ra5mh2r2zXvnjrB_zQwRhtt92OqQ0eP0WwQw9-OEEHznYJTn_mMXpezJ9mt8Xy_uZudr0sasb5UDTANSk1E0RwuW4IbyonldWUgdaNFjVjVqyZI7aquHKOQ6UoKKt0HtyW7Bhd7Hrznfm5NJi-TTV0nfUQxmRKxqTWVFUkW-nOWseQUgRnNrHtbfwylJgtaLMDbTJoswVtVM6c_9SP6x6av8Qv2Wwod4aUV_4FonkLY_T55X9avwHy3omB</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2336991780</pqid></control><display><type>article</type><title>Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Tian, Ai-ping ; Yin, Yu-kun ; Yu, Lei ; Yang, Bo-yan ; Li, Ning ; Li, Jian-ying ; Bian, Zhi-min ; Hu, Shang-ying ; Weng, Chun-xiao ; Feng, Li</creator><creatorcontrib>Tian, Ai-ping ; Yin, Yu-kun ; Yu, Lei ; Yang, Bo-yan ; Li, Ning ; Li, Jian-ying ; Bian, Zhi-min ; Hu, Shang-ying ; Weng, Chun-xiao ; Feng, Li</creatorcontrib><description>Objective
To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine (CM) formula could improve the efficacy of intrapleural administration of interleukin-2 (IL-2) in treatment of malignant pleural effusion (MPE).
Methods
A total of 110 eligible participants were randomized into the low-frequency sonophoresis (LFS) of CM (LSF/CM) group (55 cases) and the control group (55 cases) by simple randomization using a random number table. The control group was treated with an intrapleural administration of IL-2; and the LFS/CM group was treated with LFS of a CM gel formulation, combined with the same IL-2 injection as in the control group. The CM formula consisted of
Semen Lepidii, Semen Sinapis, Ramulus Cinnamomi, Poriacocos, Herba Lycopi
, and
Radix Paeoniae Rubra.
After 2-week treatment, the therapeutic outcome was determined by the change of the amount of MPE, which was evaluated by B-scan ultrasound and/or chest X-ray, and the change of quality of life (QOL) scores, which were evaluated by the Eastern Cooperative Oncology Group (ECOG) performance status.
Results
A significantly higher objective remission rate (ORR) was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone (
P
=0.049). In addition, more patients in the LFS/CM group than in the control group had an improved QOL score (
P
=0.048), and no patients in the LFS/CM group had a reduced QOL.
Conclusion
: LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients.</description><identifier>ISSN: 1672-0415</identifier><identifier>EISSN: 1993-0402</identifier><identifier>DOI: 10.1007/s11655-019-3167-7</identifier><identifier>PMID: 31444669</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Administration, Cutaneous ; Humans ; Immunotherapy ; Interleukin-2 - administration & dosage ; Medicine ; Medicine & Public Health ; Medicine, Chinese Traditional ; Original Article ; Pleural Effusion, Malignant - drug therapy ; Quality of Life ; Ultrasonic Therapy</subject><ispartof>Chinese journal of integrative medicine, 2020-04, Vol.26 (4), p.263-269</ispartof><rights>The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-de49029350546bd04d8f67a913e99d95c33a5b3f0a8847ff4e871e7a7971e4a23</citedby><cites>FETCH-LOGICAL-c344t-de49029350546bd04d8f67a913e99d95c33a5b3f0a8847ff4e871e7a7971e4a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11655-019-3167-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11655-019-3167-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31444669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Ai-ping</creatorcontrib><creatorcontrib>Yin, Yu-kun</creatorcontrib><creatorcontrib>Yu, Lei</creatorcontrib><creatorcontrib>Yang, Bo-yan</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Li, Jian-ying</creatorcontrib><creatorcontrib>Bian, Zhi-min</creatorcontrib><creatorcontrib>Hu, Shang-ying</creatorcontrib><creatorcontrib>Weng, Chun-xiao</creatorcontrib><creatorcontrib>Feng, Li</creatorcontrib><title>Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment</title><title>Chinese journal of integrative medicine</title><addtitle>Chin. J. Integr. Med</addtitle><addtitle>Chin J Integr Med</addtitle><description>Objective
To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine (CM) formula could improve the efficacy of intrapleural administration of interleukin-2 (IL-2) in treatment of malignant pleural effusion (MPE).
Methods
A total of 110 eligible participants were randomized into the low-frequency sonophoresis (LFS) of CM (LSF/CM) group (55 cases) and the control group (55 cases) by simple randomization using a random number table. The control group was treated with an intrapleural administration of IL-2; and the LFS/CM group was treated with LFS of a CM gel formulation, combined with the same IL-2 injection as in the control group. The CM formula consisted of
Semen Lepidii, Semen Sinapis, Ramulus Cinnamomi, Poriacocos, Herba Lycopi
, and
Radix Paeoniae Rubra.
After 2-week treatment, the therapeutic outcome was determined by the change of the amount of MPE, which was evaluated by B-scan ultrasound and/or chest X-ray, and the change of quality of life (QOL) scores, which were evaluated by the Eastern Cooperative Oncology Group (ECOG) performance status.
Results
A significantly higher objective remission rate (ORR) was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone (
P
=0.049). In addition, more patients in the LFS/CM group than in the control group had an improved QOL score (
P
=0.048), and no patients in the LFS/CM group had a reduced QOL.
Conclusion
: LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients.</description><subject>Administration, Cutaneous</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Interleukin-2 - administration & dosage</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Chinese Traditional</subject><subject>Original Article</subject><subject>Pleural Effusion, Malignant - drug therapy</subject><subject>Quality of Life</subject><subject>Ultrasonic Therapy</subject><issn>1672-0415</issn><issn>1993-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EouXxA7ggH7kE7PgVH1HVAlIrkICz5SZrCErsYicg_j2uChw57Ug7M9r9EDqj5JISoq4SpVKIglBdMCpVofbQlGrNCsJJuZ-1VGXWVEzQUUpvhAgliThEE0Y551LqKdosw2exiPA-gq-_8GPwYfMaIqQ24eDw7LX1kACvoGnrLPEixH7sLL7rNzF8QMJz59ra5mh2r2zXvnjrB_zQwRhtt92OqQ0eP0WwQw9-OEEHznYJTn_mMXpezJ9mt8Xy_uZudr0sasb5UDTANSk1E0RwuW4IbyonldWUgdaNFjVjVqyZI7aquHKOQ6UoKKt0HtyW7Bhd7Hrznfm5NJi-TTV0nfUQxmRKxqTWVFUkW-nOWseQUgRnNrHtbfwylJgtaLMDbTJoswVtVM6c_9SP6x6av8Qv2Wwod4aUV_4FonkLY_T55X9avwHy3omB</recordid><startdate>20200401</startdate><enddate>20200401</enddate><creator>Tian, Ai-ping</creator><creator>Yin, Yu-kun</creator><creator>Yu, Lei</creator><creator>Yang, Bo-yan</creator><creator>Li, Ning</creator><creator>Li, Jian-ying</creator><creator>Bian, Zhi-min</creator><creator>Hu, Shang-ying</creator><creator>Weng, Chun-xiao</creator><creator>Feng, Li</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200401</creationdate><title>Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment</title><author>Tian, Ai-ping ; Yin, Yu-kun ; Yu, Lei ; Yang, Bo-yan ; Li, Ning ; Li, Jian-ying ; Bian, Zhi-min ; Hu, Shang-ying ; Weng, Chun-xiao ; Feng, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-de49029350546bd04d8f67a913e99d95c33a5b3f0a8847ff4e871e7a7971e4a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Cutaneous</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Interleukin-2 - administration & dosage</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Chinese Traditional</topic><topic>Original Article</topic><topic>Pleural Effusion, Malignant - drug therapy</topic><topic>Quality of Life</topic><topic>Ultrasonic Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Ai-ping</creatorcontrib><creatorcontrib>Yin, Yu-kun</creatorcontrib><creatorcontrib>Yu, Lei</creatorcontrib><creatorcontrib>Yang, Bo-yan</creatorcontrib><creatorcontrib>Li, Ning</creatorcontrib><creatorcontrib>Li, Jian-ying</creatorcontrib><creatorcontrib>Bian, Zhi-min</creatorcontrib><creatorcontrib>Hu, Shang-ying</creatorcontrib><creatorcontrib>Weng, Chun-xiao</creatorcontrib><creatorcontrib>Feng, Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese journal of integrative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Ai-ping</au><au>Yin, Yu-kun</au><au>Yu, Lei</au><au>Yang, Bo-yan</au><au>Li, Ning</au><au>Li, Jian-ying</au><au>Bian, Zhi-min</au><au>Hu, Shang-ying</au><au>Weng, Chun-xiao</au><au>Feng, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment</atitle><jtitle>Chinese journal of integrative medicine</jtitle><stitle>Chin. J. Integr. Med</stitle><addtitle>Chin J Integr Med</addtitle><date>2020-04-01</date><risdate>2020</risdate><volume>26</volume><issue>4</issue><spage>263</spage><epage>269</epage><pages>263-269</pages><issn>1672-0415</issn><eissn>1993-0402</eissn><abstract>Objective
To evaluate whether low-frequency ultrasound-facilitated transdermal delivery of a Chinese medicine (CM) formula could improve the efficacy of intrapleural administration of interleukin-2 (IL-2) in treatment of malignant pleural effusion (MPE).
Methods
A total of 110 eligible participants were randomized into the low-frequency sonophoresis (LFS) of CM (LSF/CM) group (55 cases) and the control group (55 cases) by simple randomization using a random number table. The control group was treated with an intrapleural administration of IL-2; and the LFS/CM group was treated with LFS of a CM gel formulation, combined with the same IL-2 injection as in the control group. The CM formula consisted of
Semen Lepidii, Semen Sinapis, Ramulus Cinnamomi, Poriacocos, Herba Lycopi
, and
Radix Paeoniae Rubra.
After 2-week treatment, the therapeutic outcome was determined by the change of the amount of MPE, which was evaluated by B-scan ultrasound and/or chest X-ray, and the change of quality of life (QOL) scores, which were evaluated by the Eastern Cooperative Oncology Group (ECOG) performance status.
Results
A significantly higher objective remission rate (ORR) was obtained with intrapleural IL-2 plus LFS/CM than IL-2 treatment alone (
P
=0.049). In addition, more patients in the LFS/CM group than in the control group had an improved QOL score (
P
=0.048), and no patients in the LFS/CM group had a reduced QOL.
Conclusion
: LFS of CM formulation could effectively alleviate MPE and improve the QOL of cancer patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31444669</pmid><doi>10.1007/s11655-019-3167-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Chinese journal of integrative medicine, 2020-04, Vol.26 (4), p.263-269 |
| issn | 1672-0415 1993-0402 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | Administration, Cutaneous Humans Immunotherapy Interleukin-2 - administration & dosage Medicine Medicine & Public Health Medicine, Chinese Traditional Original Article Pleural Effusion, Malignant - drug therapy Quality of Life Ultrasonic Therapy |
| title | Low-Frequency Sonophoresis of Chinese Medicine Formula Improves Efficacy of Malignant Pleural Effusion Treatment |
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